TRIO (triple functional domain (PTPRF interacting))

Identity

Other names	FLJ42780
	tgat
HGNC	TRIO
Location	5p14-p15.1
Location_base_pair	Starts at 14196829 and ends at 14562458 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TRIO   12303
Entrez_Gene	TRIO  7204  triple functional domain (PTPRF interacting)
	Cards
GeneCards	TRIO
Ensembl	TRIO [Search_View]   ENSG00000038382 [Gene_View]
Genatlas	TRIO
GeneLynx	TRIO
eGenome	TRIO
euGene	7204
	Genomic and cartography
GoldenPath	TRIO  -     chr5:14196829-14562458 +  5p15.2   [Description]    (hg18-March_2006)
Ensembl	TRIO - 5p15.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TRIO
	Gene and transcription
Genbank	AB115332 [ ENTREZ ]
Genbank	AB209754 [ ENTREZ ]
Genbank	AF091395 [ ENTREZ ]
Genbank	AI478154 [ ENTREZ ]
Genbank	AK124770 [ ENTREZ ]
RefSeq	NM_007118 [ SRS ]    NM_007118 [ ENTREZ ]
RefSeq	AC_000048 [ SRS ]    AC_000048 [ ENTREZ ]
RefSeq	AC_000137 [ SRS ]    AC_000137 [ ENTREZ ]
RefSeq	NC_000005 [ SRS ]    NC_000005 [ ENTREZ ]
RefSeq	NT_006576 [ SRS ]    NT_006576 [ ENTREZ ]
RefSeq	NW_001838927 [ SRS ]    NW_001838927 [ ENTREZ ]
RefSeq	NW_922518 [ SRS ]    NW_922518 [ ENTREZ ]
AceView	TRIO AceView - NCBI
Unigene	Hs.130031 [ SRS ]    Hs.130031 [ NCBI ]     HS130031 [ spliceNest ]
Fast-db	1676 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O75962 [ SRS]    O75962 [ EXPASY ]     O75962 [ INTERPRO ]     O75962 [ UNIPROT ]
Prosite	PS50191 CRAL_TRIO [ SRS ]    PS50191 CRAL_TRIO [ Expasy ]
Prosite	PS00741 DH_1 [ SRS ]    PS00741 DH_1 [ Expasy ]
Prosite	PS50010 DH_2 [ SRS ]    PS50010 DH_2 [ Expasy ]
Prosite	PS50835 IG_LIKE [ SRS ]    PS50835 IG_LIKE [ Expasy ]
Prosite	PS50003 PH_DOMAIN [ SRS ]    PS50003 PH_DOMAIN [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Prosite	PS50002 SH3 [ SRS ]    PS50002 SH3 [ Expasy ]
Interpro	IPR001251 CRAL_bd_TRIO_C [ SRS ]    IPR001251 CRAL_bd_TRIO_C [ EBI ]
Interpro	IPR000219 DH-domain [ SRS ]    IPR000219 DH-domain [ EBI ]
Interpro	IPR001331 GDS_CDC24_CS [ SRS ]    IPR001331 GDS_CDC24_CS [ EBI ]
Interpro	IPR007110 Ig-like [ SRS ]    IPR007110 Ig-like [ EBI ]
Interpro	IPR013783 Ig-like_fold [ SRS ]    IPR013783 Ig-like_fold [ EBI ]
Interpro	IPR013098 Ig_I-set [ SRS ]    IPR013098 Ig_I-set [ EBI ]
Interpro	IPR003598 Ig_sub2 [ SRS ]    IPR003598 Ig_sub2 [ EBI ]
Interpro	IPR001849 PH [ SRS ]    IPR001849 PH [ EBI ]
Interpro	IPR011993 PH_type [ SRS ]    IPR011993 PH_type [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
Interpro	IPR001452 SH3 [ SRS ]    IPR001452 SH3 [ EBI ]
Interpro	IPR002017 Spectrin_repeat [ SRS ]    IPR002017 Spectrin_repeat [ EBI ]
CluSTr	O75962
Pfam	PF07679 I-set [ SRS ]    PF07679 I-set [ Sanger ]    pfam07679 [ NCBI-CDD ]
Pfam	PF00169 PH [ SRS ]    PF00169 PH [ Sanger ]    pfam00169 [ NCBI-CDD ]
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Pfam	PF00621 RhoGEF [ SRS ]    PF00621 RhoGEF [ Sanger ]    pfam00621 [ NCBI-CDD ]
Pfam	PF00018 SH3_1 [ SRS ]    PF00018 SH3_1 [ Sanger ]    pfam00018 [ NCBI-CDD ]
Pfam	PF00435 Spectrin [ SRS ]    PF00435 Spectrin [ Sanger ]    pfam00435 [ NCBI-CDD ]
Smart	SM00408 IGc2 [EMBL]
Smart	SM00233 PH [EMBL]
Smart	SM00325 RhoGEF [EMBL]
Smart	SM00220 S_TKc [EMBL]
Smart	SM00516 SEC14 [EMBL]
Smart	SM00326 SH3 [EMBL]
Smart	SM00150 SPEC [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	O75962 TRIO_HUMAN [ Domain structure ]   O75962 TRIO_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	O75962
PDB	1NTY [ SRS ]    1NTY [ PdbSum ],   1NTY [ IMB ]   1NTY [ RSDB ]
PDB	2NZ8 [ SRS ]    2NZ8 [ PdbSum ],   2NZ8 [ IMB ]   2NZ8 [ RSDB ]
HPRD	03537
	Protein Interaction databases
DIP	O75962
IntAct	O75962
	Polymorphism : SNP, mutations, diseases
OMIM	601893    [ map ]
GENECLINICS	601893
SNP	TRIO [dbSNP-NCBI]
SNP	NM_007118 [SNP-NCI]
SNP	TRIO [GeneSNPs - Utah]  TRIO] [HGBASE - SRS]
HAPMAP	TRIO [HAPMAP]
COSMIC	TRIO [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TRIO
	General knowledge
Family Browser	TRIO [UCSC Family Browser]
SOURCE	NM_007118
SMD	Hs.130031
SAGE	Hs.130031
Enzyme	2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   2.7.11.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	guanyl-nucleotide exchange factor activity [Amigo]  guanyl-nucleotide exchange factor activity
GO	Rho guanyl-nucleotide exchange factor activity [Amigo]  Rho guanyl-nucleotide exchange factor activity
GO	ATP binding [Amigo]  ATP binding
GO	intracellular [Amigo]  intracellular
GO	cytoplasm [Amigo]  cytoplasm
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	transmembrane receptor protein tyrosine phosphatase signaling pathway [Amigo]  transmembrane receptor protein tyrosine phosphatase signaling pathway
GO	transferase activity [Amigo]  transferase activity
GO	regulation of Rho protein signal transduction [Amigo]  regulation of Rho protein signal transduction
BIOCARTA	Rac 1 cell motility signaling pathway    [Genes]
PubGene	TRIO
TreeFam	TRIO
CTD	7204 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TRIO Related clones (RZPD - Berlin)
	PubMed
PubMed	21 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:36:23 2008