TXN2 (thioredoxin 2)

2012-01-01  

Identity

HGNC
LOCATION
22q12.3
LOCUSID
ALIAS
COXPD29,MT-TRX,MTRX,TRX2,TXN
FUSION GENES

Other Information

Locus ID:

NCBI: 25828
MIM: 609063
HGNC: 17772
Ensembl: ENSG00000100348

Variants:

dbSNP: 25828
ClinVar: 25828
TCGA: ENSG00000100348
COSMIC: TXN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100348ENST00000216185Q99757
ENSG00000100348ENST00000403313Q99757
ENSG00000100348ENST00000411915F8WDN2
ENSG00000100348ENST00000416967M0QXH0

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
184972922008Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins.206
175480472007Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress.60
120321452002Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells.48
120800522002Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death.43
209298582010Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3.42
176344802007Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer.35
213272972011Targeting S100P inhibits colon cancer growth and metastasis by Lentivirus-mediated RNA interference and proteomic analysis.32
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
164240622006Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer.25
191245062009Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.22

Citation

Dessen P

TXN2 (thioredoxin 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52545/txn2