UBA3 (ubiquitin like modifier activating enzyme 3)

2007-04-01 Affiliation

Identity

HGNC

UBA3

LOCATION

3p14.1

LOCUSID

9039

ALIAS

NAE2,UBE1C,hUBA3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9039
MIM: 603172
HGNC: 12470
Ensembl: ENSG00000144744

Variants:

dbSNP: 9039
ClinVar: 9039
TCGA: ENSG00000144744
COSMIC: UBA3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000144744	ENST00000349511	Q8TBC4
ENSG00000144744	ENST00000361055	Q8TBC4
ENSG00000144744	ENST00000415609	F8W8D4
ENSG00000144744	ENST00000461934	F8WAT6
ENSG00000144744	ENST00000465627	F8WF86
ENSG00000144744	ENST00000630585	F8WF86
ENSG00000144744	ENST00000631029	A0A0D9SF81

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ubiquitin mediated proteolysis	KEGG	ko04120
Ubiquitin mediated proteolysis	KEGG	hsa04120
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Innate Immune System	REACTOME	R-HSA-168249
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CLEC7A (Dectin-1) signaling	REACTOME	R-HSA-5607764
Dectin-1 mediated noncanonical NF-kB signaling	REACTOME	R-HSA-5607761
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
NIK-->noncanonical NF-kB signaling	REACTOME	R-HSA-5676590

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
14690597	2003	The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.	89
12646924	2003	Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.	75
15694336	2005	Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.	75
12740388	2003	Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.	41
24525735	2014	Suppression of tumor angiogenesis by targeting the protein neddylation pathway.	25
25229838	2014	Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target.	24
18652489	2008	Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.	21
24691136	2014	Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells.	9
22821745	2012	E2-binding surface on Uba3 β-grasp domain undergoes a conformational transition.	1

Citation

Dessen P

UBA3 (ubiquitin like modifier activating enzyme 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47097/uba3