UBE2E2 (ubiquitin conjugating enzyme E2 E2)

2007-04-01  

Identity

HGNC
UBE2E2
LOCATION
3p24.3
LOCUSID
7325
ALIAS
UBCH8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7325
MIM: 602163
HGNC: 12478
Ensembl: ENSG00000182247

Variants:

dbSNP: 7325
ClinVar: 7325
TCGA: ENSG00000182247
COSMIC: UBE2E2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182247ENST00000335798F8W8F0
ENSG00000182247ENST00000396703Q96LR5
ENSG00000182247ENST00000396703A0A024R2Q2
ENSG00000182247ENST00000425792Q96LR5
ENSG00000182247ENST00000425792A0A024R2Q2
ENSG00000182247ENST00000452894C9J180
ENSG00000182247ENST00000613545A0A087X283
ENSG00000182247ENST00000628311F8WF15

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208183812010A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.108
208183812010A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.108
154859252004Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation.88
117865352002Regulation of synaptophysin degradation by mammalian homologues of seven in absentia.68
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
279185342017Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation.38
155453182004Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import.36
272812732016Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score.10
186493582008Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.6
278630922017Associations between changes in the maternal gut microbiome and differentially methylated regions of diabetes-associated genes in fetuses: A pilot study from a birth cohort study.4

Citation

Dessen P

UBE2E2 (ubiquitin conjugating enzyme E2 E2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47212/ube2e2