UBE2I (ubiquitin conjugating enzyme E2 I)

2003-11-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
C358B7.1,P18,UBC9
FUSION GENES

Other Information

Locus ID:

NCBI: 7329
MIM: 601661
HGNC: 12485
Ensembl: ENSG00000103275

Variants:

dbSNP: 7329
ClinVar: 7329
TCGA: ENSG00000103275
COSMIC: UBE2I

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103275ENST00000325437P63279
ENSG00000103275ENST00000355803P63279
ENSG00000103275ENST00000397514P63279
ENSG00000103275ENST00000397515P63279
ENSG00000103275ENST00000402301B0QYN7
ENSG00000103275ENST00000403747P63279
ENSG00000103275ENST00000406620P63279
ENSG00000103275ENST00000566587P63279
ENSG00000103275ENST00000566775H3BPC4
ENSG00000103275ENST00000567074H3BQQ9
ENSG00000103275ENST00000567383H3BRD1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Nuclear pore complexKEGGhsa_M00427
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Nuclear pore complexKEGGM00427
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
Processing and activation of SUMOREACTOMER-HSA-3215018
SUMO is transferred from E1 to E2 (UBE2I, UBC9)REACTOMER-HSA-3065678
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
SUMOylation of transcription factorsREACTOMER-HSA-3232118
SUMOylation of chromatin organization proteinsREACTOMER-HSA-4551638
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464
SUMOylation of DNA replication proteinsREACTOMER-HSA-4615885
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
Negative regulation of activity of TFAP2 (AP-2) family transcription factorsREACTOMER-HSA-8866904

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD19859084
PA449014cisplatinChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD19859084
PA450085irinotecanChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD19859084

References

Pubmed IDYearTitleCitations
159312242005Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.191
179567322007RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia.96
186919692008Ubc9 sumoylation regulates SUMO target discrimination.78
128130452003SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4.67
157357602005A role for Ubc9 in tumorigenesis.63
156086512005Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection.59
151920802004Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9.58
174663332007Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction.55
200237052010Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner.49
118774162002Identification of a substrate recognition site on Ubc9.45

Citation

Dessen P

UBE2I (ubiquitin conjugating enzyme E2 I)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42751/ube2i