VAV2 (vav 2 guanine nucleotide exchange factor)

Identity

Other names	-
HGNC	VAV2
Location	9q34.1
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	VAV2   12658
Entrez_Gene	VAV2  7410  vav 2 guanine nucleotide exchange factor
	Cards
GeneCards	VAV2
Ensembl	VAV2 [Search_View]   ENSG00000160293 [Gene_View]
Genatlas	VAV2
GeneLynx	VAV2
eGenome	VAV2
euGene	7410
	Genomic and cartography
GoldenPath	VAV2  -  9q34.1   chr9:135616837-135847226 -  9q34.2   [Description]    (hg18-March_2006)
Ensembl	VAV2 - 9q34.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	VAV2
	Gene and transcription
Genbank	AF258564 [ ENTREZ ]
Genbank	AJ420448 [ ENTREZ ]
Genbank	AK091622 [ ENTREZ ]
Genbank	AK123314 [ ENTREZ ]
Genbank	AK130475 [ ENTREZ ]
RefSeq	NM_003371 [ SRS ]    NM_003371 [ ENTREZ ]
RefSeq	AC_000052 [ SRS ]    AC_000052 [ ENTREZ ]
RefSeq	AC_000141 [ SRS ]    AC_000141 [ ENTREZ ]
RefSeq	NC_000009 [ SRS ]    NC_000009 [ ENTREZ ]
RefSeq	NT_035014 [ SRS ]    NT_035014 [ ENTREZ ]
RefSeq	NW_001839242 [ SRS ]    NW_001839242 [ ENTREZ ]
RefSeq	NW_924573 [ SRS ]    NW_924573 [ ENTREZ ]
AceView	VAV2 AceView - NCBI
Unigene	Hs.689325 [ SRS ]    Hs.689325 [ NCBI ]     HS689325 [ spliceNest ]
Fast-db	16432 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P52735 [ SRS]    P52735 [ EXPASY ]     P52735 [ INTERPRO ]     P52735 [ UNIPROT ]
Prosite	PS50021 CH [ SRS ]    PS50021 CH [ Expasy ]
Prosite	PS00741 DH_1 [ SRS ]    PS00741 DH_1 [ Expasy ]
Prosite	PS50010 DH_2 [ SRS ]    PS50010 DH_2 [ Expasy ]
Prosite	PS50003 PH_DOMAIN [ SRS ]    PS50003 PH_DOMAIN [ Expasy ]
Prosite	PS50001 SH2 [ SRS ]    PS50001 SH2 [ Expasy ]
Prosite	PS50002 SH3 [ SRS ]    PS50002 SH3 [ Expasy ]
Prosite	PS00479 ZF_DAG_PE_1 [ SRS ]    PS00479 ZF_DAG_PE_1 [ Expasy ]
Prosite	PS50081 ZF_DAG_PE_2 [ SRS ]    PS50081 ZF_DAG_PE_2 [ Expasy ]
Interpro	IPR016146 Calponin-homology [ SRS ]    IPR016146 Calponin-homology [ EBI ]
Interpro	IPR001715 Calponin_act_bd [ SRS ]    IPR001715 Calponin_act_bd [ EBI ]
Interpro	IPR002219 DAG_PE_bd [ SRS ]    IPR002219 DAG_PE_bd [ EBI ]
Interpro	IPR000219 DH-domain [ SRS ]    IPR000219 DH-domain [ EBI ]
Interpro	IPR001331 GDS_CDC24_CS [ SRS ]    IPR001331 GDS_CDC24_CS [ EBI ]
Interpro	IPR001849 PH [ SRS ]    IPR001849 PH [ EBI ]
Interpro	IPR000980 SH2 [ SRS ]    IPR000980 SH2 [ EBI ]
Interpro	IPR001452 SH3 [ SRS ]    IPR001452 SH3 [ EBI ]
Interpro	IPR011511 SH3_2 [ SRS ]    IPR011511 SH3_2 [ EBI ]
CluSTr	P52735
Pfam	PF00130 C1_1 [ SRS ]    PF00130 C1_1 [ Sanger ]    pfam00130 [ NCBI-CDD ]
Pfam	PF00307 CH [ SRS ]    PF00307 CH [ Sanger ]    pfam00307 [ NCBI-CDD ]
Pfam	PF00169 PH [ SRS ]    PF00169 PH [ Sanger ]    pfam00169 [ NCBI-CDD ]
Pfam	PF00621 RhoGEF [ SRS ]    PF00621 RhoGEF [ Sanger ]    pfam00621 [ NCBI-CDD ]
Pfam	PF00017 SH2 [ SRS ]    PF00017 SH2 [ Sanger ]    pfam00017 [ NCBI-CDD ]
Pfam	PF00018 SH3_1 [ SRS ]    PF00018 SH3_1 [ Sanger ]    pfam00018 [ NCBI-CDD ]
Pfam	PF07653 SH3_2 [ SRS ]    PF07653 SH3_2 [ Sanger ]    pfam07653 [ NCBI-CDD ]
Smart	SM00109 C1 [EMBL]
Smart	SM00033 CH [EMBL]
Smart	SM00233 PH [EMBL]
Smart	SM00325 RhoGEF [EMBL]
Smart	SM00252 SH2 [EMBL]
Smart	SM00326 SH3 [EMBL]
Prodom	PD000093 SH2[INRA-Toulouse]
Prodom	P52735 VAV2_HUMAN [ Domain structure ]   P52735 VAV2_HUMAN  [ sequences sharing at least 1 domain ]
Prodom	PD000093[INRA-Toulouse]
Prodom	P52735 VAV2_HUMAN [ Domain structure ]   P52735 VAV2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P52735
PDB	2DLZ [ SRS ]    2DLZ [ PdbSum ],   2DLZ [ IMB ]   2DLZ [ RSDB ]
PDB	2DM1 [ SRS ]    2DM1 [ PdbSum ],   2DM1 [ IMB ]   2DM1 [ RSDB ]
HPRD	02694
	Protein Interaction databases
DIP	P52735
IntAct	P52735
	Polymorphism : SNP, mutations, diseases
OMIM	600428    [ map ]
GENECLINICS	600428
SNP	VAV2 [dbSNP-NCBI]
SNP	NM_003371 [SNP-NCI]
SNP	VAV2 [GeneSNPs - Utah]  VAV2] [HGBASE - SRS]
HAPMAP	VAV2 [HAPMAP]
COSMIC	VAV2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	VAV2
	General knowledge
Family Browser	VAV2 [UCSC Family Browser]
SOURCE	NM_003371
SMD	Hs.689325
SAGE	Hs.689325
GO	guanyl-nucleotide exchange factor activity [Amigo]  guanyl-nucleotide exchange factor activity
GO	Rho guanyl-nucleotide exchange factor activity [Amigo]  Rho guanyl-nucleotide exchange factor activity
GO	epidermal growth factor receptor binding [Amigo]  epidermal growth factor receptor binding
GO	protein binding [Amigo]  protein binding
GO	intracellular [Amigo]  intracellular
GO	cytoplasm [Amigo]  cytoplasm
GO	plasma membrane [Amigo]  plasma membrane
GO	small GTPase mediated signal transduction [Amigo]  small GTPase mediated signal transduction
GO	zinc ion binding [Amigo]  zinc ion binding
GO	cell migration [Amigo]  cell migration
GO	diacylglycerol binding [Amigo]  diacylglycerol binding
GO	lamellipodium biogenesis [Amigo]  lamellipodium biogenesis
GO	regulation of Rho protein signal transduction [Amigo]  regulation of Rho protein signal transduction
GO	positive regulation of phosphoinositide 3-kinase activity [Amigo]  positive regulation of phosphoinositide 3-kinase activity
GO	metal ion binding [Amigo]  metal ion binding
BIOCARTA	Phosphoinositides and their downstream targets.    [Genes]
KEGG	Focal adhesion
KEGG	Natural killer cell mediated cytotoxicity
KEGG	T cell receptor signaling pathway
KEGG	B cell receptor signaling pathway
KEGG	Fc epsilon RI signaling pathway
KEGG	Leukocyte transendothelial migration
KEGG	Regulation of actin cytoskeleton
PubGene	VAV2
TreeFam	VAV2
CTD	7410 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	VAV2 Related clones (RZPD - Berlin)
	PubMed
PubMed	29 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:37:50 2008