VAV3 (vav 3 guanine nucleotide exchange factor)

Identity

Other names	FLJ40431
HGNC	VAV3
Location	1p13.3
Location_base_pair	Starts at 107915305 and ends at 108032649 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	VAV3   12659
Entrez_Gene	VAV3  10451  vav 3 guanine nucleotide exchange factor
	Cards
GeneCards	VAV3
Ensembl	ENSG00000134215 [Gene_View]  VAV3 [Vega]
Genatlas	VAV3
	Genomic and cartography
GoldenPath	VAV3  -  1p13.3   chr1:107915305-108032649 -  1p13.3   [Description]    (hg18-March_2006)
Ensembl	VAV3 - 1p13.3 [CytoView]
NCBI	Mapview
OMIM	605541 Disease map [OMIM]
HomoloGene	VAV3
	Gene and transcription
Genbank	AF035442 [ ENTREZ ]
Genbank	AF067817 [ ENTREZ ]
Genbank	AF118886 [ ENTREZ ]
Genbank	AF118887 [ ENTREZ ]
Genbank	AI304566 [ ENTREZ ]
RefSeq	NM_001079874 [ SRS ]    NM_001079874 [ ENTREZ ]
RefSeq	NM_006113 [ SRS ]    NM_006113 [ ENTREZ ]
RefSeq	AC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeq	AC_000133 [ SRS ]    AC_000133 [ ENTREZ ]
RefSeq	NC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeq	NT_019273 [ SRS ]    NT_019273 [ ENTREZ ]
RefSeq	NW_001838590 [ SRS ]    NW_001838590 [ ENTREZ ]
RefSeq	NW_922017 [ SRS ]    NW_922017 [ ENTREZ ]
CCDS	VAV3 CCDS - NCBI
AceView	VAV3 AceView - NCBI
Unigene	Hs.267659 [ SRS ]    Hs.267659 [ NCBI ]
Fast-db	16931 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O60498 [ SRS]    O60498 [ EXPASY ]     O60498 [ INTERPRO ]     O60498 [ UNIPROT ] O60498 [ VarSplice FASTA ]
Prosite	PS50002 SH3 [ SRS ]    PS50002 SH3 [ Expasy ]
Interpro	IPR000980 SH2 [ SRS ]    IPR000980 SH2 [ EBI ]
Interpro	IPR001452 SH3 [ SRS ]    IPR001452 SH3 [ EBI ]
Interpro	IPR011511 SH3_2 [ SRS ]    IPR011511 SH3_2 [ EBI ]
CluSTr	O60498
Pfam	PF07653 SH3_2 [ SRS ]    PF07653 SH3_2 [ Sanger ]    pfam07653 [ NCBI-CDD ]
Smart	SM00326 SH3 [EMBL]
Prodom	PD000093 SH2[INRA-Toulouse]
Prodom	O60498 O60498_HUMAN [ Domain structure ]   O60498 O60498_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	O60498
HPRD	05706
	Protein Interaction databases
DIP	O60498
IntAct	O60498
	Polymorphism : SNP, mutations, diseases
OMIM	605541    [ map ]
GENETests	605541
SNP	VAV3 [dbSNP-NCBI]
SNP	NM_001079874 [SNP-NCI]
SNP	NM_006113 [SNP-NCI]
SNP	VAV3 [GeneSNPs - Utah]  VAV3] [HGBASE - SRS]
HAPMAP	VAV3 [HAPMAP]
COSMIC	VAV3 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	VAV3
Genetic Association	VAV3
CDC HuGE	VAV3
	General knowledge
Family Browser	VAV3 [UCSC Family Browser]
SOURCE	NM_001079874
SOURCE	NM_006113
SMD	Hs.267659
SAGE	Hs.267659
GO	SH3/SH2 adaptor activity [Amigo]  SH3/SH2 adaptor activity
GO	guanyl-nucleotide exchange factor activity [Amigo]  guanyl-nucleotide exchange factor activity
GO	Rho guanyl-nucleotide exchange factor activity [Amigo]  Rho guanyl-nucleotide exchange factor activity
GO	GTPase activator activity [Amigo]  GTPase activator activity
GO	protein binding [Amigo]  protein binding
GO	intracellular [Amigo]  intracellular
GO	small GTPase mediated signal transduction [Amigo]  small GTPase mediated signal transduction
GO	zinc ion binding [Amigo]  zinc ion binding
GO	diacylglycerol binding [Amigo]  diacylglycerol binding
GO	regulation of Rho protein signal transduction [Amigo]  regulation of Rho protein signal transduction
GO	metal ion binding [Amigo]  metal ion binding
KEGG	Focal adhesion
KEGG	Natural killer cell mediated cytotoxicity
KEGG	T cell receptor signaling pathway
KEGG	B cell receptor signaling pathway
KEGG	Fc epsilon RI signaling pathway
KEGG	Leukocyte transendothelial migration
KEGG	Regulation of actin cytoskeleton
PubGene	VAV3
TreeFam	VAV3
CTD	10451 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	VAV3 Related clones (RZPD - Berlin)
	PubMed
PubMed	18 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Dec 6 17:14:25 2008