VEGFA (vascular endothelial growth factor A)

Identity

Other names	MGC70609
	VEGF
	VEGF-A
	VPF
HGNC	VEGFA
Location	6p12
Location_base_pair	Starts at 43845931 and ends at 43862201 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

External links

	Nomenclature
HGNC	VEGFA   12680
Entrez_Gene	VEGFA  7422  vascular endothelial growth factor A
	Cards
GeneCards	VEGFA
Ensembl	ENSG00000112715 [Gene_View]  VEGFA [Vega]
Genatlas	VEGFA
	Genomic and cartography
GoldenPath	VEGFA  -  6p12   chr6:43845931-43862201 +  6p21.1   [Description]    (hg18-March_2006)
Ensembl	VEGFA - 6p21.1 [CytoView]
NCBI	Mapview
OMIM	125853 Disease map [OMIM]
OMIM	192240 Disease map [OMIM]
HomoloGene	VEGFA
	Gene and transcription
Genbank	AB021221 [ ENTREZ ]
Genbank	AB209485 [ ENTREZ ]
Genbank	AF022375 [ ENTREZ ]
Genbank	AF024710 [ ENTREZ ]
Genbank	AF062645 [ ENTREZ ]
RefSeq	NM_001025366 [ SRS ]    NM_001025366 [ ENTREZ ]
RefSeq	NM_001025367 [ SRS ]    NM_001025367 [ ENTREZ ]
RefSeq	NM_001025368 [ SRS ]    NM_001025368 [ ENTREZ ]
RefSeq	NM_001025369 [ SRS ]    NM_001025369 [ ENTREZ ]
RefSeq	NM_001025370 [ SRS ]    NM_001025370 [ ENTREZ ]
RefSeq	NM_001033756 [ SRS ]    NM_001033756 [ ENTREZ ]
RefSeq	NM_003376 [ SRS ]    NM_003376 [ ENTREZ ]
RefSeq	AC_000049 [ SRS ]    AC_000049 [ ENTREZ ]
RefSeq	AC_000138 [ SRS ]    AC_000138 [ ENTREZ ]
RefSeq	NC_000006 [ SRS ]    NC_000006 [ ENTREZ ]
RefSeq	NT_007592 [ SRS ]    NT_007592 [ ENTREZ ]
RefSeq	NW_001838981 [ SRS ]    NW_001838981 [ ENTREZ ]
RefSeq	NW_923073 [ SRS ]    NW_923073 [ ENTREZ ]
CCDS	VEGFA CCDS - NCBI
AceView	VEGFA AceView - NCBI
Unigene	Hs.73793 [ SRS ]    Hs.73793 [ NCBI ]
Fast-db	12043 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P15692 [ SRS]    P15692 [ EXPASY ]     P15692 [ INTERPRO ]     P15692 [ UNIPROT ] P15692 [ VarSplice FASTA ]
Prosite	PS00249 PDGF_1 [ SRS ]    PS00249 PDGF_1 [ Expasy ]
Prosite	PS50278 PDGF_2 [ SRS ]    PS50278 PDGF_2 [ Expasy ]
Interpro	IPR000072 PD_growth_factor [ SRS ]    IPR000072 PD_growth_factor [ EBI ]
CluSTr	P15692
Pfam	PF00341 PDGF [ SRS ]    PF00341 PDGF [ Sanger ]    pfam00341 [ NCBI-CDD ]
Smart	SM00141 PDGF [EMBL]
Prodom	PD001629 PD_growth_factor[INRA-Toulouse]
Prodom	P15692 VEGFA_HUMAN [ Domain structure ]   P15692 VEGFA_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P15692
PDB	1BJ1 [ SRS ]    1BJ1 [ PdbSum ],   1BJ1 [ IMB ]   1BJ1 [ RSDB ]
PDB	1CZ8 [ SRS ]    1CZ8 [ PdbSum ],   1CZ8 [ IMB ]   1CZ8 [ RSDB ]
PDB	1FLT [ SRS ]    1FLT [ PdbSum ],   1FLT [ IMB ]   1FLT [ RSDB ]
PDB	1KAT [ SRS ]    1KAT [ PdbSum ],   1KAT [ IMB ]   1KAT [ RSDB ]
PDB	1KMX [ SRS ]    1KMX [ PdbSum ],   1KMX [ IMB ]   1KMX [ RSDB ]
PDB	1MJV [ SRS ]    1MJV [ PdbSum ],   1MJV [ IMB ]   1MJV [ RSDB ]
PDB	1MKG [ SRS ]    1MKG [ PdbSum ],   1MKG [ IMB ]   1MKG [ RSDB ]
PDB	1MKK [ SRS ]    1MKK [ PdbSum ],   1MKK [ IMB ]   1MKK [ RSDB ]
PDB	1QTY [ SRS ]    1QTY [ PdbSum ],   1QTY [ IMB ]   1QTY [ RSDB ]
PDB	1TZH [ SRS ]    1TZH [ PdbSum ],   1TZH [ IMB ]   1TZH [ RSDB ]
PDB	1TZI [ SRS ]    1TZI [ PdbSum ],   1TZI [ IMB ]   1TZI [ RSDB ]
PDB	1VGH [ SRS ]    1VGH [ PdbSum ],   1VGH [ IMB ]   1VGH [ RSDB ]
PDB	1VPF [ SRS ]    1VPF [ PdbSum ],   1VPF [ IMB ]   1VPF [ RSDB ]
PDB	1VPP [ SRS ]    1VPP [ PdbSum ],   1VPP [ IMB ]   1VPP [ RSDB ]
PDB	2FJG [ SRS ]    2FJG [ PdbSum ],   2FJG [ IMB ]   2FJG [ RSDB ]
PDB	2FJH [ SRS ]    2FJH [ PdbSum ],   2FJH [ IMB ]   2FJH [ RSDB ]
PDB	2QR0 [ SRS ]    2QR0 [ PdbSum ],   2QR0 [ IMB ]   2QR0 [ RSDB ]
PDB	2VGH [ SRS ]    2VGH [ PdbSum ],   2VGH [ IMB ]   2VGH [ RSDB ]
PDB	2VPF [ SRS ]    2VPF [ PdbSum ],   2VPF [ IMB ]   2VPF [ RSDB ]
HPRD	01889
	Protein Interaction databases
DIP	P15692
IntAct	P15692
	Polymorphism : SNP, mutations, diseases
OMIM	125853    [ map ]
OMIM	192240    [ map ]
GENETests	125853
GENETests	192240
SNP	VEGFA [dbSNP-NCBI]
SNP	NM_001025366 [SNP-NCI]
SNP	NM_001025367 [SNP-NCI]
SNP	NM_001025368 [SNP-NCI]
SNP	NM_001025369 [SNP-NCI]
SNP	NM_001025370 [SNP-NCI]
SNP	NM_001033756 [SNP-NCI]
SNP	NM_003376 [SNP-NCI]
SNP	VEGFA [GeneSNPs - Utah]  VEGFA] [HGBASE - SRS]
HAPMAP	VEGFA [HAPMAP]
HGMD	VEGFA
Genetic Association	VEGFA
CDC HuGE	VEGFA
	General knowledge
Family Browser	VEGFA [UCSC Family Browser]
SOURCE	NM_001025366
SOURCE	NM_001025367
SOURCE	NM_001025368
SOURCE	NM_001025369
SOURCE	NM_001025370
SOURCE	NM_001033756
SOURCE	NM_003376
SMD	Hs.73793
SAGE	Hs.73793
GO	angiogenesis [Amigo]  angiogenesis
GO	angiogenesis [Amigo]  angiogenesis
GO	vasculogenesis [Amigo]  vasculogenesis
GO	response to hypoxia [Amigo]  response to hypoxia
GO	platelet-derived growth factor receptor binding [Amigo]  platelet-derived growth factor receptor binding
GO	vascular endothelial growth factor receptor binding [Amigo]  vascular endothelial growth factor receptor binding
GO	protein binding [Amigo]  protein binding
GO	extracellular region [Amigo]  extracellular region
GO	extracellular region [Amigo]  extracellular region
GO	proteinaceous extracellular matrix [Amigo]  proteinaceous extracellular matrix
GO	extracellular space [Amigo]  extracellular space
GO	extracellular space [Amigo]  extracellular space
GO	signal transduction [Amigo]  signal transduction
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	nervous system development [Amigo]  nervous system development
GO	growth factor activity [Amigo]  growth factor activity
GO	growth factor activity [Amigo]  growth factor activity
GO	heparin binding [Amigo]  heparin binding
GO	cell proliferation [Amigo]  cell proliferation
GO	positive regulation of cell proliferation [Amigo]  positive regulation of cell proliferation
GO	cell surface [Amigo]  cell surface
GO	membrane [Amigo]  membrane
GO	positive regulation of cell migration [Amigo]  positive regulation of cell migration
GO	positive regulation of vascular endothelial growth factor receptor signaling pathway [Amigo]  positive regulation of vascular endothelial growth factor receptor signaling pathway
GO	platelet alpha granule lumen [Amigo]  platelet alpha granule lumen
GO	protein homodimerization activity [Amigo]  protein homodimerization activity
GO	negative regulation of apoptosis [Amigo]  negative regulation of apoptosis
GO	cell surface binding [Amigo]  cell surface binding
GO	platelet-derived growth factor receptor signaling pathway [Amigo]  platelet-derived growth factor receptor signaling pathway
GO	extracellular matrix binding [Amigo]  extracellular matrix binding
GO	induction of positive chemotaxis [Amigo]  induction of positive chemotaxis
BIOCARTA	Hypoxia-Inducible Factor in the Cardiovascular System    [Genes]
BIOCARTA	Actions of Nitric Oxide in the Heart    [Genes]
BIOCARTA	VEGF, Hypoxia, and Angiogenesis    [Genes]
KEGG	Cytokine-cytokine receptor interaction
KEGG	mTOR signaling pathway
KEGG	VEGF signaling pathway
KEGG	Focal adhesion
PubGene	VEGFA
TreeFam	VEGFA
CTD	7422 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	VEGFA Related clones (RZPD - Berlin)
	PubMed
PubMed	499 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Dec 6 17:14:27 2008