VWF (von Willebrand factor)

Identity

Other names	F8VWF
	VWD
HGNC	VWF
Location	12p13.3
Location_base_pair	Starts at 5928301 and ends at 6104097 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	VWF   12726
Entrez_Gene	VWF  7450  von Willebrand factor
	Cards
GeneCards	VWF
Ensembl	VWF [Search_View]   ENSG00000110799 [Gene_View]
Genatlas	VWF
GeneLynx	VWF
eGenome	VWF
euGene	7450
	Genomic and cartography
GoldenPath	VWF  -  12p13.3   chr12:5928301-6104097 -  12p13.31   [Description]    (hg18-March_2006)
Ensembl	VWF - 12p13.31 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	VWF
	Gene and transcription
Genbank	AF086470 [ ENTREZ ]
Genbank	AK292122 [ ENTREZ ]
Genbank	BC022258 [ ENTREZ ]
Genbank	BG951111 [ ENTREZ ]
Genbank	BQ898017 [ ENTREZ ]
RefSeq	NM_000552 [ SRS ]    NM_000552 [ ENTREZ ]
RefSeq	AC_000055 [ SRS ]    AC_000055 [ ENTREZ ]
RefSeq	AC_000144 [ SRS ]    AC_000144 [ ENTREZ ]
RefSeq	NC_000012 [ SRS ]    NC_000012 [ ENTREZ ]
RefSeq	NT_009759 [ SRS ]    NT_009759 [ ENTREZ ]
RefSeq	NW_001838050 [ SRS ]    NW_001838050 [ ENTREZ ]
RefSeq	NW_925295 [ SRS ]    NW_925295 [ ENTREZ ]
AceView	VWF AceView - NCBI
Unigene	Hs.440848 [ SRS ]    Hs.440848 [ NCBI ]     HS440848 [ spliceNest ]
Fast-db	862 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P04275 [ SRS]    P04275 [ EXPASY ]     P04275 [ INTERPRO ]     P04275 [ UNIPROT ]
Prosite	PS01185 CTCK_1 [ SRS ]    PS01185 CTCK_1 [ Expasy ]
Prosite	PS01225 CTCK_2 [ SRS ]    PS01225 CTCK_2 [ Expasy ]
Prosite	PS50234 VWFA [ SRS ]    PS50234 VWFA [ Expasy ]
Prosite	PS01208 VWFC_1 [ SRS ]    PS01208 VWFC_1 [ Expasy ]
Prosite	PS50184 VWFC_2 [ SRS ]    PS50184 VWFC_2 [ Expasy ]
Prosite	PS51233 VWFD [ SRS ]    PS51233 VWFD [ Expasy ]
Interpro	IPR006207 Cys_knot_C [ SRS ]    IPR006207 Cys_knot_C [ EBI ]
Interpro	IPR014853 DUF1787 [ SRS ]    IPR014853 DUF1787 [ EBI ]
Interpro	IPR002919 Prot_Inh_CR_TIL [ SRS ]    IPR002919 Prot_Inh_CR_TIL [ EBI ]
Interpro	IPR012011 VWF [ SRS ]    IPR012011 VWF [ EBI ]
Interpro	IPR002035 VWF_A [ SRS ]    IPR002035 VWF_A [ EBI ]
Interpro	IPR001007 VWF_C [ SRS ]    IPR001007 VWF_C [ EBI ]
Interpro	IPR001846 VWF_D [ SRS ]    IPR001846 VWF_D [ EBI ]
CluSTr	P04275
Pfam	PF08742 DUF1787 [ SRS ]    PF08742 DUF1787 [ Sanger ]    pfam08742 [ NCBI-CDD ]
Pfam	PF01826 TIL [ SRS ]    PF01826 TIL [ Sanger ]    pfam01826 [ NCBI-CDD ]
Pfam	PF00092 VWA [ SRS ]    PF00092 VWA [ Sanger ]    pfam00092 [ NCBI-CDD ]
Pfam	PF00093 VWC [ SRS ]    PF00093 VWC [ Sanger ]    pfam00093 [ NCBI-CDD ]
Pfam	PF00094 VWD [ SRS ]    PF00094 VWD [ Sanger ]    pfam00094 [ NCBI-CDD ]
Smart	SM00041 CT [EMBL]
Smart	SM00327 VWA [EMBL]
Smart	SM00214 VWC [EMBL]
Smart	SM00216 VWD [EMBL]
Blocks	P04275
PDB	1AO3 [ SRS ]    1AO3 [ PdbSum ],   1AO3 [ IMB ]   1AO3 [ RSDB ]
PDB	1ATZ [ SRS ]    1ATZ [ PdbSum ],   1ATZ [ IMB ]   1ATZ [ RSDB ]
PDB	1AUQ [ SRS ]    1AUQ [ PdbSum ],   1AUQ [ IMB ]   1AUQ [ RSDB ]
PDB	1FE8 [ SRS ]    1FE8 [ PdbSum ],   1FE8 [ IMB ]   1FE8 [ RSDB ]
PDB	1FNS [ SRS ]    1FNS [ PdbSum ],   1FNS [ IMB ]   1FNS [ RSDB ]
PDB	1IJB [ SRS ]    1IJB [ PdbSum ],   1IJB [ IMB ]   1IJB [ RSDB ]
PDB	1IJK [ SRS ]    1IJK [ PdbSum ],   1IJK [ IMB ]   1IJK [ RSDB ]
PDB	1M10 [ SRS ]    1M10 [ PdbSum ],   1M10 [ IMB ]   1M10 [ RSDB ]
PDB	1OAK [ SRS ]    1OAK [ PdbSum ],   1OAK [ IMB ]   1OAK [ RSDB ]
PDB	1SQ0 [ SRS ]    1SQ0 [ PdbSum ],   1SQ0 [ IMB ]   1SQ0 [ RSDB ]
PDB	1U0N [ SRS ]    1U0N [ PdbSum ],   1U0N [ IMB ]   1U0N [ RSDB ]
PDB	1UEX [ SRS ]    1UEX [ PdbSum ],   1UEX [ IMB ]   1UEX [ RSDB ]
PDB	2ADF [ SRS ]    2ADF [ PdbSum ],   2ADF [ IMB ]   2ADF [ RSDB ]
HPRD	01906
	Protein Interaction databases
DIP	P04275
IntAct	P04275
	Polymorphism : SNP, mutations, diseases
OMIM	193400    [ map ]
GENECLINICS	193400
SNP	VWF [dbSNP-NCBI]
SNP	NM_000552 [SNP-NCI]
SNP	VWF [GeneSNPs - Utah]  VWF] [HGBASE - SRS]
HAPMAP	VWF [HAPMAP]
HGMD	VWF
	General knowledge
Family Browser	VWF [UCSC Family Browser]
SOURCE	NM_000552
SMD	Hs.440848
SAGE	Hs.440848
GO	glycoprotein binding [Amigo]  glycoprotein binding
GO	protease binding [Amigo]  protease binding
GO	integrin binding [Amigo]  integrin binding
GO	collagen binding [Amigo]  collagen binding
GO	extracellular region [Amigo]  extracellular region
GO	extracellular region [Amigo]  extracellular region
GO	extracellular region [Amigo]  extracellular region
GO	proteinaceous extracellular matrix [Amigo]  proteinaceous extracellular matrix
GO	endoplasmic reticulum [Amigo]  endoplasmic reticulum
GO	plasma membrane [Amigo]  plasma membrane
GO	response to wounding [Amigo]  response to wounding
GO	immunoglobulin binding [Amigo]  immunoglobulin binding
GO	platelet activation [Amigo]  platelet activation
GO	platelet activation [Amigo]  platelet activation
GO	platelet alpha granule [Amigo]  platelet alpha granule
GO	cell-substrate adhesion [Amigo]  cell-substrate adhesion
GO	Weibel-Palade body [Amigo]  Weibel-Palade body
GO	protein homodimerization activity [Amigo]  protein homodimerization activity
GO	protein N-terminus binding [Amigo]  protein N-terminus binding
GO	chaperone binding [Amigo]  chaperone binding
GO	protein homooligomerization [Amigo]  protein homooligomerization
KEGG	Cell Communication
KEGG	Focal adhesion
KEGG	ECM-receptor interaction
KEGG	Complement and coagulation cascades
PubGene	VWF
TreeFam	VWF
CTD	7450 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	VWF Related clones (RZPD - Berlin)
	PubMed
PubMed	303 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:37:53 2008