WEE1 (WEE1 G2 checkpoint kinase)

2003-05-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
WEE1A,WEE1hu
FUSION GENES

Other Information

Locus ID:

NCBI: 7465
MIM: 193525
HGNC: 12761
Ensembl: ENSG00000166483

Variants:

dbSNP: 7465
ClinVar: 7465
TCGA: ENSG00000166483
COSMIC: WEE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166483ENST00000299613P30291
ENSG00000166483ENST00000450114P30291
ENSG00000166483ENST00000524612E9PQ51
ENSG00000166483ENST00000527848E9PRI3
ENSG00000166483ENST00000530175H0YEJ2
ENSG00000166483ENST00000530712E9PRU3

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Cell cycle - G2/M transitionKEGGhsa_M00693
Cell cycle - G2/M transitionKEGGM00693
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
G2/M DNA replication checkpointREACTOMER-HSA-69478
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Cyclin E associated events during G1/S transitionREACTOMER-HSA-69202
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Cyclin A/B1 associated events during G2/M transitionREACTOMER-HSA-69273
Polo-like kinase mediated eventsREACTOMER-HSA-156711

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
150707332004M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.192
208327522010In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma.92
229077502012Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.88
266028152015Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
218598612011Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.66
147601182004The clinical significance of Cyclin B1 and Wee1 expression in non-small-cell lung cancer.59
191265502009let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts.58
159648262005Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition.55
126013502003Cyclins and cyclin-dependent kinases: comparative study of hepatocellular carcinoma versus cirrhosis.51

Citation

Dessen P

WEE1 (WEE1 G2 checkpoint kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42807/wee1