WHSC1 (Wolf-Hirschhorn syndrome candidate 1)

Identity

Other names	FLJ23286
	KIAA1090
	MGC176638
	MMSET
	NSD2
	REIIBP
	TRX5
	WHS
Hugo	WHSC1
Location	4p16.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
Hugo	WHSC1
GDB	WHSC1
Entrez_Gene	WHSC1  7468  Wolf-Hirschhorn syndrome candidate 1
	Cards
GeneCards	WHSC1
Ensembl	WHSC1 [Search_View]   ENSG00000109685 [Gene_View]
Genatlas	WHSC1
GeneLynx	WHSC1
eGenome	WHSC1
euGene	7468
	Genomic and cartography
GoldenPath	WHSC1  -  4p16.3   chr4:1864307-1914100 +  4p16.3   [Description]    (hg18-March_2006)
Ensembl	WHSC1 - 4p16.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	WHSC1
	Gene and transcription
Genbank	AB029013 [ ENTREZ ]
Genbank	AF071593 [ ENTREZ ]
Genbank	AF071594 [ ENTREZ ]
Genbank	AF083386 [ ENTREZ ]
Genbank	AF083387 [ ENTREZ ]
RefSeq	NM_001042424 [ SRS ]    NM_001042424 [ ENTREZ ]
RefSeq	NM_007331 [ SRS ]    NM_007331 [ ENTREZ ]
RefSeq	NM_133330 [ SRS ]    NM_133330 [ ENTREZ ]
RefSeq	NM_133331 [ SRS ]    NM_133331 [ ENTREZ ]
RefSeq	NM_133334 [ SRS ]    NM_133334 [ ENTREZ ]
RefSeq	NM_133335 [ SRS ]    NM_133335 [ ENTREZ ]
RefSeq	NM_133336 [ SRS ]    NM_133336 [ ENTREZ ]
RefSeq	AC_000047 [ SRS ]    AC_000047 [ ENTREZ ]
RefSeq	NC_000004 [ SRS ]    NC_000004 [ ENTREZ ]
RefSeq	NT_006081 [ SRS ]    NT_006081 [ ENTREZ ]
RefSeq	NW_921918 [ SRS ]    NW_921918 [ ENTREZ ]
AceView	WHSC1 AceView - NCBI
Unigene	Hs.113876 [ SRS ]    Hs.113876 [ NCBI ]     HS113876 [ spliceNest ]
Fast-db	1163 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O96028 [ SRS]    O96028 [ EXPASY ]     O96028 [ INTERPRO ]
Prosite	PS51215 AWS [ SRS ]    PS51215 AWS [ Expasy ]
Prosite	PS50118 HMG_BOX_2 [ SRS ]    PS50118 HMG_BOX_2 [ Expasy ]
Prosite	PS50868 POST_SET [ SRS ]    PS50868 POST_SET [ Expasy ]
Prosite	PS50812 PWWP [ SRS ]    PS50812 PWWP [ Expasy ]
Prosite	PS50280 SET [ SRS ]    PS50280 SET [ Expasy ]
Prosite	PS01359 ZF_PHD_1 [ SRS ]    PS01359 ZF_PHD_1 [ Expasy ]
Prosite	PS50016 ZF_PHD_2 [ SRS ]    PS50016 ZF_PHD_2 [ Expasy ]
Interpro	IPR006560 AWS [ SRS ]    IPR006560 AWS [ EBI ]
Interpro	IPR000910 HMG_1/2_box [ SRS ]    IPR000910 HMG_1/2_box [ EBI ]
Interpro	IPR003616 Post-SET_Zn_bd [ SRS ]    IPR003616 Post-SET_Zn_bd [ EBI ]
Interpro	IPR000313 PWWP [ SRS ]    IPR000313 PWWP [ EBI ]
Interpro	IPR001214 SET [ SRS ]    IPR001214 SET [ EBI ]
Interpro	IPR001965 Znf_PHD [ SRS ]    IPR001965 Znf_PHD [ EBI ]
Interpro	IPR001841 Znf_RING [ SRS ]    IPR001841 Znf_RING [ EBI ]
Interpro	IPR013083 Znf_RING/FYVE/PHD [ SRS ]    IPR013083 Znf_RING/FYVE/PHD [ EBI ]
CluSTr	O96028
Pfam	PF00505 HMG_box [ SRS ]    PF00505 HMG_box [ Sanger ]    pfam00505 [ NCBI-CDD ]
Pfam	PF00628 PHD [ SRS ]    PF00628 PHD [ Sanger ]    pfam00628 [ NCBI-CDD ]
Pfam	PF00855 PWWP [ SRS ]    PF00855 PWWP [ Sanger ]    pfam00855 [ NCBI-CDD ]
Pfam	PF00856 SET [ SRS ]    PF00856 SET [ Sanger ]    pfam00856 [ NCBI-CDD ]
Smart	SM00570 AWS [EMBL]
Smart	SM00398 HMG [EMBL]
Smart	SM00249 PHD [EMBL]
Smart	SM00508 PostSET [EMBL]
Smart	SM00293 PWWP [EMBL]
Smart	SM00184 RING [EMBL]
Smart	SM00317 SET [EMBL]
Blocks	O96028
HPRD	04259
	Protein Interaction databases
DIP	O96028
IntAct	O96028
	Polymorphism : SNP, mutations, diseases
OMIM	602952    [ map ]
GENECLINICS	602952
SNP	WHSC1 [dbSNP-NCBI]
SNP	NM_001042424 [SNP-NCI]
SNP	NM_007331 [SNP-NCI]
SNP	NM_133330 [SNP-NCI]
SNP	NM_133331 [SNP-NCI]
SNP	NM_133334 [SNP-NCI]
SNP	NM_133335 [SNP-NCI]
SNP	NM_133336 [SNP-NCI]
SNP	WHSC1 [GeneSNPs - Utah]  WHSC1] [HGBASE - SRS]
HAPMAP	WHSC1 [HAPMAP]
COSMIC	WHSC1 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	DNA [Translocation breakpoints In Cancer]
HGMD	WHSC1
	General knowledge
Family Browser	WHSC1 [UCSC Family Browser]
SOURCE	NM_001042424
SOURCE	NM_007331
SOURCE	NM_133330
SOURCE	NM_133331
SOURCE	NM_133334
SOURCE	NM_133335
SOURCE	NM_133336
SMD	Hs.113876
SAGE	Hs.113876
Enzyme	2.1.1.43 [ Enzyme-SRS ]   2.1.1.43 [ Brenda-SRS ]   2.1.1.43 [ KEGG ]   2.1.1.43 [ WIT ]
GO	DNA binding [Amigo]  DNA binding
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	transcription [Amigo]  transcription
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	methyltransferase activity [Amigo]  methyltransferase activity
GO	zinc ion binding [Amigo]  zinc ion binding
GO	anatomical structure morphogenesis [Amigo]  anatomical structure morphogenesis
GO	chromatin modification [Amigo]  chromatin modification
GO	transferase activity [Amigo]  transferase activity
GO	histone-lysine N-methyltransferase activity [Amigo]  histone-lysine N-methyltransferase activity
GO	metal ion binding [Amigo]  metal ion binding
PubGene	WHSC1
TreeFam	WHSC1
CTD	7468 [Comparative Genomics Database]
	Other databases
	Probes
Probe	WHSC1 Related clones (RZPD - Berlin)
	PubMed
PubMed	23 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu May 22 20:35:12 2008