WNT5B (Wnt family member 5B)

2003-02-01  

Identity

HGNC
LOCATION
12p13.33
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 81029
MIM: 606361
HGNC: 16265
Ensembl: ENSG00000111186

Variants:

dbSNP: 81029
ClinVar: 81029
TCGA: ENSG00000111186
COSMIC: WNT5B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111186ENST00000310594Q9H1J7
ENSG00000111186ENST00000397196Q9H1J7
ENSG00000111186ENST00000537031Q9H1J7
ENSG00000111186ENST00000539198F5H034
ENSG00000111186ENST00000542408F5GYM2
ENSG00000111186ENST00000543071F5H7Q6
ENSG00000111186ENST00000545811F5H364

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
Axon guidanceKEGGko04360
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
Axon guidanceKEGGhsa04360
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD23817222
PA164713176Platinum compoundsChemicalClinicalAnnotationassociatedPD24980784
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD24980784
PA443756Colonic NeoplasmsDiseaseClinicalAnnotationassociatedPD23817222

References

Pubmed IDYearTitleCitations
153862142004Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes.48
277620902017Wnt5b-associated exosomes promote cancer cell migration and proliferation.28
248412002014MicroRNA-200b suppresses arsenic-transformed cell migration by targeting protein kinase Cα and Wnt5b-protein kinase Cα positive feedback loop and inhibiting Rac1 activation.27
275939382017Tumour cell-derived WNT5B modulates in vitro lymphangiogenesis via induction of partial endothelial-mesenchymal transition of lymphatic endothelial cells.22
240404392013The differential expression of TGF-β1, ILK and wnt signaling inducing epithelial to mesenchymal transition in human renal fibrogenesis: an immunohistochemical study.21
245648882014Wnt modulates MCL1 to control cell survival in triple negative breast cancer.21
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
121658122002Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells.18
243447322014Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B.18
279323502017Role of Noncanonical Wnt Signaling Pathway in Human Aortic Valve Calcification.15

Citation

Dessen P

WNT5B (Wnt family member 5B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42826/wnt5b