XAB2 (XPA binding protein 2)

2003-12-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
HCNP,HCRN,NTC90,SYF1
FUSION GENES

Other Information

Locus ID:

NCBI: 56949
MIM: 610850
HGNC: 14089
Ensembl: ENSG00000076924

Variants:

dbSNP: 56949
ClinVar: 56949
TCGA: ENSG00000076924
COSMIC: XAB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000076924ENST00000358368Q9HCS7

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, 35S U5-snRNPKEGGhsa_M00355
Spliceosome, 35S U5-snRNPKEGGM00355
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

References

Pubmed IDYearTitleCitations
179818042008Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair.40
270849402016Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination.13
205225372010Variation within DNA repair pathway genes and risk of multiple sclerosis.11
277359372016XAB2 functions in mitotic cell cycle progression via transcriptional regulation of CENPE.8
262286552015XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population.4
250272822014Hematopoietic myeloid cell differentiation diminishes nucleotide excision repair.2
256718122015Identification of the specific interactors of the human lariat RNA debranching enzyme 1 protein.1
312160222019XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence.0

Citation

Dessen P

XAB2 (XPA binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42840/xab2