YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta)

2008-01-01  

Identity

HGNC
LOCATION
2p25.1
LOCUSID
ALIAS
14-3-3,1C5,HS1
FUSION GENES

Other Information

Locus ID:

NCBI: 10971
MIM: 609009
HGNC: 12854
Ensembl: ENSG00000134308

Variants:

dbSNP: 10971
ClinVar: 10971
TCGA: ENSG00000134308
COSMIC: YWHAQ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134308ENST00000238081P27348
ENSG00000134308ENST00000381844P27348
ENSG00000134308ENST00000446619E9PG15

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Pathogenic Escherichia coli infectionKEGGko05130
Cell cycleKEGGhsa04110
Pathogenic Escherichia coli infectionKEGGhsa05130
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BAD and translocation to mitochondriaREACTOMER-HSA-111447

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125355172003Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.275
120423142002Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.96
176170582007Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.64
185508562008Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding.64
187945472008Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.61
204513862010Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis.59
201103482010Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.49
179137092007Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding.38
182491872008Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53.38
195924912009Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.36

Citation

Dessen P

YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49987/ywhaq