ZEB1 (zinc finger E-box binding homeobox 1)

Identity

Other names	AREB6
	BZP
	DELTA-EF1
	MGC133261
	NIL-2-A
	NIL-2A
	NIL2A
	TCF8
	ZEB
	ZFHEP
	ZFHX1A
HGNC	ZEB1
Location	10p11.22
Location_base_pair	Starts at 31650070 and ends at 31858130 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

External links

	Nomenclature
HGNC	ZEB1   11642
Entrez_Gene	ZEB1  6935  zinc finger E-box binding homeobox 1
	Cards
GeneCards	ZEB1
Ensembl	ENSG00000148516 [Gene_View]  ZEB1 [Vega]
Genatlas	ZEB1
	Genomic and cartography
GoldenPath	ZEB1  -  10p11.22   chr10:31650070-31858130 +  10p11.22   [Description]    (hg18-March_2006)
Ensembl	ZEB1 - 10p11.22 [CytoView]
NCBI	Mapview
OMIM	189909 Disease map [OMIM]
OMIM	609141 Disease map [OMIM]
HomoloGene	ZEB1
	Gene and transcription
Genbank	AK091478 [ ENTREZ ]
Genbank	AK307510 [ ENTREZ ]
Genbank	AK308785 [ ENTREZ ]
Genbank	AK308822 [ ENTREZ ]
Genbank	AK309331 [ ENTREZ ]
RefSeq	NM_001128128 [ SRS ]    NM_001128128 [ ENTREZ ]
RefSeq	NM_030751 [ SRS ]    NM_030751 [ ENTREZ ]
RefSeq	AC_000053 [ SRS ]    AC_000053 [ ENTREZ ]
RefSeq	AC_000142 [ SRS ]    AC_000142 [ ENTREZ ]
RefSeq	NC_000010 [ SRS ]    NC_000010 [ ENTREZ ]
RefSeq	NT_008705 [ SRS ]    NT_008705 [ ENTREZ ]
RefSeq	NW_001837932 [ SRS ]    NW_001837932 [ ENTREZ ]
RefSeq	NW_924584 [ SRS ]    NW_924584 [ ENTREZ ]
CCDS	ZEB1 CCDS - NCBI
AceView	ZEB1 AceView - NCBI
Unigene	Hs.124503 [ SRS ]    Hs.124503 [ NCBI ]
Fast-db	7514 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P37275 [ SRS]    P37275 [ EXPASY ]     P37275 [ INTERPRO ]     P37275 [ UNIPROT ] P37275 [ VarSplice FASTA ]
Prosite	PS00027 HOMEOBOX_1 [ SRS ]    PS00027 HOMEOBOX_1 [ Expasy ]
Prosite	PS50071 HOMEOBOX_2 [ SRS ]    PS50071 HOMEOBOX_2 [ Expasy ]
Prosite	PS00028 ZINC_FINGER_C2H2_1 [ SRS ]    PS00028 ZINC_FINGER_C2H2_1 [ Expasy ]
Prosite	PS50157 ZINC_FINGER_C2H2_2 [ SRS ]    PS50157 ZINC_FINGER_C2H2_2 [ Expasy ]
Interpro	IPR001356 Homeobox [ SRS ]    IPR001356 Homeobox [ EBI ]
Interpro	IPR007087 Znf_C2H2 [ SRS ]    IPR007087 Znf_C2H2 [ EBI ]
Interpro	IPR015880 Znf_C2H2-like [ SRS ]    IPR015880 Znf_C2H2-like [ EBI ]
Interpro	IPR013087 Znf_C2H2/integrase_DNA-bd [ SRS ]    IPR013087 Znf_C2H2/integrase_DNA-bd [ EBI ]
CluSTr	P37275
Pfam	PF00096 zf-C2H2 [ SRS ]    PF00096 zf-C2H2 [ Sanger ]    pfam00096 [ NCBI-CDD ]
Smart	SM00389 HOX [EMBL]
Smart	SM00355 ZnF_C2H2 [EMBL]
Prodom	PD000010 Homeobox[INRA-Toulouse]
Prodom	P37275 ZEB1_HUMAN [ Domain structure ]   P37275 ZEB1_HUMAN  [ sequences sharing at least 1 domain ]
Prodom	PD000010[INRA-Toulouse]
Prodom	P37275 ZEB1_HUMAN [ Domain structure ]   P37275 ZEB1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P37275
PDB	2,00E+19 [ SRS ]    2,00E+19 [ PdbSum ],   2,00E+19 [ IMB ]   2,00E+19 [ RSDB ]
HPRD	01798
	Protein Interaction databases
DIP	P37275
IntAct	P37275
	Polymorphism : SNP, mutations, diseases
OMIM	189909    [ map ]
OMIM	609141    [ map ]
GENETests	189909
GENETests	609141
SNP	ZEB1 [dbSNP-NCBI]
SNP	NM_001128128 [SNP-NCI]
SNP	NM_030751 [SNP-NCI]
SNP	ZEB1 [GeneSNPs - Utah]  ZEB1] [HGBASE - SRS]
HAPMAP	ZEB1 [HAPMAP]
HGMD	ZEB1
Genetic Association	ZEB1
CDC HuGE	ZEB1
	General knowledge
Family Browser	ZEB1 [UCSC Family Browser]
SOURCE	NM_001128128
SOURCE	NM_030751
SMD	Hs.124503
SAGE	Hs.124503
GO	negative regulation of transcription from RNA polymerase II promoter [Amigo]  negative regulation of transcription from RNA polymerase II promoter
GO	transcription factor activity [Amigo]  transcription factor activity
GO	transcription factor activity [Amigo]  transcription factor activity
GO	transcription coactivator activity [Amigo]  transcription coactivator activity
GO	transcription corepressor activity [Amigo]  transcription corepressor activity
GO	intracellular [Amigo]  intracellular
GO	nucleus [Amigo]  nucleus
GO	transcription [Amigo]  transcription
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	immune response [Amigo]  immune response
GO	zinc ion binding [Amigo]  zinc ion binding
GO	zinc ion binding [Amigo]  zinc ion binding
GO	cell proliferation [Amigo]  cell proliferation
GO	sequence-specific DNA binding [Amigo]  sequence-specific DNA binding
GO	metal ion binding [Amigo]  metal ion binding
BIOCARTA	SUMOylation as a mechanism to modulate CtBP-dependent gene responses    [Genes]
PubGene	ZEB1
TreeFam	ZEB1
CTD	6935 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ZEB1 Related clones (RZPD - Berlin)
	PubMed
PubMed	39 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Dec 6 17:15:19 2008