ICAM1 (intercellular adhesion molecule 1 (CD54), human rhinovirus receptor)

Identity

Other names	BB2
	CD54
	ICAM-1
	P3.58
HGNC	ICAM1
Location	19p13.2
Location_base_pair	Starts at 10242517 and ends at 10258291 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

Description	ICAM1 gene maps on chromosome 19p13.3-p13.2 scanning 15512 bp.
Transcription	7 exon; mRNA 3249 bp.

Protein

Description	A transmembrane glycoprotein of 532 amino acids, which has a molecular mass ranging from 75 to 115 kDa. ICAM-1 is a member of the immunoglobulin supergenge family, and contains five extracellular immunoglobulin-like domains.
Expression	ICAM-1 is expressed on various cells of both hematopoietic and non-hematopoietic cells, including endothelial cells, leukocytes other than basophilic granulocytes, T cells, B cells, fibroblasts, and cancer cells.
Function	ICAM-1, a member of adhesion molecules, binds to two integrins belonging to the beta2 subfamily CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) on the surface of leukocytes. ICAM1 is a key molecule in immune-mediated and inflammatory processes and function as a co-stimulatory signal which is important for the trans-endothelial migration of leukocytes and the activation of T cells. ICAM-1 can be induced under inflammatory condition by TNF-alpha in a process that involves IKK-beta. ICAM1 on target cells leads to recruitment of the MHC-I proteins to the contact area and enhances presentation of cognate peptide MHC-I complex to cytotoxic T cells. ICAM-1 interacts with important factors involved in many kinds of human cancers. ICAM-1 is involved in transmembrane signal transduction in the regulatory process of cell proliferation through the mitogen-activated protein kinase (MAPK) pathway and eventually the AP-1 pathway (Springer, 1990; Dustin et al., 1998; Simmons et al., 1988; Caras et al., 1987; Rothlein et al., 1986; Dustin et al., 1986; Tsujisaki et al., 1991; Gardiner et D'Souza, 1999).

Implicated in

Entity	Melanoma
Disease	ICAM-1 expresses with a dose- and time-dependent increase in human malignant melanoma cells on stimulation of TNF-alpha. Inhibition of ICAM-1 expression on melanoma cells reduces the metastatic ability of the melanoma cells, indicating an important role of ICAM-1 in metastasis (Miele et al., 1994).
Entity	Hepatocellular carcinoma
Disease	Serum concentration of ICAM-1 (sICAM-1) in patients with hepatocellular carcinoma is a marker for disease progression and prognosis. Higher sICAM-1 levels are more frequently observed in those patients with multiple lesions and intra-hepatic metastasis (Mei et al., 2000).
Entity	Prostate cancer
Disease	Two polymorphisms and a common haplotype within the ICAM-1 gene cluster were correlated with prostate cancer risk among men with family history of the disease (Chen et al., 2006).
Entity	Colon cancer
Disease	ICAM-1 expression is decreased in colorectal cancer (Berndt et al., 2008).
Entity	Gastric cancer
Disease	Decreased ICAM expression leads to lymph node metastasis, suggesting that ICAM-1 gene transfection can inhibit lymph node metastasis (Tanaka et al., 2002; Yashiro et al., 2005).
Entity	Head and neck cancer
Disease	sICAM-1 shows a significant elevation in the sera of patients with nasopharyngeal carcinoma compared to healthy controls (Liu et al., 1999).
Entity	Leukemia
Disease	A high expression of ICAM-1 may identify high-risk MDS (Graf et al., 2005).
Entity	Breast Cancer
Disease	ICAM-1 down-regulation at the mRNA and protein levels led to a suppression of breast cells invasion (Rosette et al., 2005).

External links

	Nomenclature
HGNC	ICAM1   5344
Entrez_Gene	ICAM1  3383  intercellular adhesion molecule 1
	Cards
Atlas	ICAM1ID40909ch19p13
GeneCards	ICAM1
Ensembl	ENSG00000090339 [Gene_View]  ICAM1 [Vega]
Genatlas	ICAM1
	Genomic and cartography
GoldenPath	ICAM1  -  19p13.2   chr19:10242517-10258291 +  19p13.3-p13.2   [Description]    (hg18-Mar_2006)
Ensembl	ICAM1 - 19p13.3-p13.2 [CytoView]
NCBI	Mapview
OMIM	147840 Disease map [OMIM]
OMIM	248310 Disease map [OMIM]
OMIM	611162 Disease map [OMIM]
HomoloGene	ICAM1
	Gene and transcription
Genbank	AF340038 [ ENTREZ ]
Genbank	AF340039 [ ENTREZ ]
Genbank	AK130659 [ ENTREZ ]
Genbank	AK312636 [ ENTREZ ]
Genbank	BC015969 [ ENTREZ ]
RefSeq	NM_000201 [ SRS ]    NM_000201 [ ENTREZ ]
RefSeq	AC_000062 [ SRS ]    AC_000062 [ ENTREZ ]
RefSeq	AC_000151 [ SRS ]    AC_000151 [ ENTREZ ]
RefSeq	NC_000019 [ SRS ]    NC_000019 [ ENTREZ ]
RefSeq	NG_007728 [ SRS ]    NG_007728 [ ENTREZ ]
RefSeq	NT_011295 [ SRS ]    NT_011295 [ ENTREZ ]
RefSeq	NW_001838483 [ SRS ]    NW_001838483 [ ENTREZ ]
RefSeq	NW_927195 [ SRS ]    NW_927195 [ ENTREZ ]
CCDS	ICAM1 CCDS - NCBI
AceView	ICAM1 AceView - NCBI
Unigene	Hs.707983 [ SRS ]    Hs.707983 [ NCBI ]
Fast-db	6038 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O00177 [ SRS]    O00177 [ EXPASY ]     O00177 [ INTERPRO ]     O00177 [ UNIPROT ] O00177 [ VarSplice FASTA ]
Interpro	IPR013768 ICAM_N [ SRS ]    IPR013768 ICAM_N [ EBI ]
Interpro	IPR013783 Ig-like_fold [ SRS ]    IPR013783 Ig-like_fold [ EBI ]
CluSTr	O00177
Pfam	PF03921 ICAM_N [ SRS ]    PF03921 ICAM_N [ Sanger ]    pfam03921 [ NCBI-CDD ]
Blocks	O00177
HPRD	00996
	Protein Interaction databases
DIP	O00177
IntAct	O00177
	Polymorphism : SNP, mutations, diseases
OMIM	147840    [ map ]
OMIM	248310    [ map ]
OMIM	611162    [ map ]
GENETests	147840
GENETests	248310
GENETests	611162
SNP	ICAM1 [dbSNP-NCBI]
SNP	NM_000201 [SNP-NCI]
SNP	ICAM1 [GeneSNPs - Utah]  ICAM1] [HGBASE - SRS]
HAPMAP	ICAM1 [HAPMAP]
HGMD	ICAM1
Genetic Association	ICAM1
CDC HuGE	ICAM1
	General knowledge
Family Browser	ICAM1 [UCSC Family Browser]
SOURCE	NM_000201
SMD	Hs.707983
SAGE	Hs.707983
GO	transmembrane receptor activity [Amigo]  transmembrane receptor activity
GO	protein binding [Amigo]  protein binding
GO	extracellular space [Amigo]  extracellular space
GO	plasma membrane [Amigo]  plasma membrane
GO	plasma membrane [Amigo]  plasma membrane
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	leukocyte adhesion [Amigo]  leukocyte adhesion
GO	external side of plasma membrane [Amigo]  external side of plasma membrane
GO	membrane to membrane docking [Amigo]  membrane to membrane docking
GO	regulation of cell adhesion [Amigo]  regulation of cell adhesion
GO	interspecies interaction between organisms [Amigo]  interspecies interaction between organisms
GO	leukocyte migration [Amigo]  leukocyte migration
BIOCARTA	Cells and Molecules involved in local acute inflammatory response    [Genes]
BIOCARTA	B Lymphocyte Cell Surface Molecules    [Genes]
BIOCARTA	CTL mediated immune response against target cells    [Genes]
BIOCARTA	Adhesion and Diapedesis of Granulocytes    [Genes]
BIOCARTA	Adhesion and Diapedesis of Lymphocytes    [Genes]
BIOCARTA	Adhesion Molecules on Lymphocyte    [Genes]
BIOCARTA	Monocyte and its Surface Molecules    [Genes]
BIOCARTA	Neutrophil and Its Surface Molecules    [Genes]
BIOCARTA	T Cytotoxic Cell Surface Molecules    [Genes]
BIOCARTA	T Helper Cell Surface Molecules    [Genes]
KEGG	Cell adhesion molecules (CAMs)
KEGG	Natural killer cell mediated cytotoxicity
KEGG	Leukocyte transendothelial migration
PubGene	ICAM1
TreeFam	ICAM1
CTD	3383 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ICAM1 Related clones (RZPD - Berlin)
	PubMed
PubMed	437 Pubmed reference(s) in Entrez

Bibliography

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA.

J Immunol. 1986 Jul 1;137(1):245-54.

PMID 3086451

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.

Rothlein R, Dustin ML, Marlin SD, Springer TA.

J Immunol. 1986 Aug 15;137(4):1270-4.

PMID 3525675

Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins.

Caras IW, Davitz MA, Rhee L, Weddell G, Martin DW Jr, Nussenzweig V.

Nature. 1987 Feb 5-11;325(6104):545-9.

PMID 2433596

Supergene families meet in the immune system.

Dustin ML, Staunton DE, Springer TA.

Immunol Today. 1988 Jul-Aug;9(7-8):213-5.

PMID 3076418

ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM.

Simmons D, Makgoba MW, Seed B.

Nature. 1988 Feb 18;331(6157):624-7.

PMID 3340213

Adhesion receptors of the immune system.

Springer TA.

Nature. 1990 Aug 2;346(6283):425-34.

PMID 1974032

Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases.

Tsujisaki M, Imai K, Hirata H, Hanzawa Y, Masuya J, Nakano T, Sugiyama T, Matsui M, Hinoda Y, Yachi A.

Clin Exp Immunol. 1991 Jul;85(1):3-8.

PMID 1712683

Enhanced metastatic ability of TNF-alpha-treated malignant melanoma cells is reduced by intercellular adhesion molecule-1 (ICAM-1, CD54) antisense oligonucleotides.

Miele ME, Bennett CF, Miller BE, Welch DR.

Exp Cell Res. 1994 Sep;214(1):231-41.

PMID 7915992

Sequences within fibrinogen and intercellular adhesion molecule-1 (ICAM-1) modulate signals required for mitogenesis.

Gardiner EE, D'Souza SE.

J Biol Chem. 1999 Apr 23;274(17):11930-6.

PMID 10207014

Circulating intercellular adhesion molecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM-1) in head and neck cancer.

Liu CM, Sheen TS, Ko JY, Shun CT.

Br J Cancer. 1999 Jan;79(2):360-2.

PMID 9888481

Clinical significance of serum intercellular adhesion molecule-1 detection in patients with hepatocellular carcinoma.

Mei MH, Xu J, Shi QF, Yang JH, Chen Q, Qin LL.

World J Gastroenterol. 2000 Jun;6(3):408-410.

PMID 11819611

Lipid-mediated gene transfection of intercellular adhesion molecule-1 suppresses the peritoneal metastasis of gastric carcinoma.

Tanaka H, Yashiro M, Sunami T, Ohira M, Hirakawa-Y S Chung K.

Int J Mol Med. 2002 Nov;10(5):613-7.

PMID 12373302

High expression of costimulatory molecules correlates with low relapse-free survival probability in acute myeloid leukemia (AML).

Graf M, Reif S, Hecht K, Pelka-Fleischer R, Kroell T, Pfister K, Schmetzer H.

Ann Hematol. 2005 May;84(5):287-97. Epub 2004 Dec 7.

PMID 15592672

Role of ICAM1 in invasion of human breast cancer cells.

Rosette C, Roth RB, Oeth P, Braun A, Kammerer S, Ekblom J, Denissenko MF.

Carcinogenesis. 2005 May;26(5):943-50. Epub 2005 Mar 17.

PMID 15774488

CD54 expression is predictive for lymphatic spread in human gastric carcinoma.

Yashiro M, Sunami T, Hirakawa K.

Dig Dis Sci. 2005 Dec;50(12):2224-30.

PMID 16416166

ICAM gene cluster SNPs and prostate cancer risk in African Americans.

Chen H, Hernandez W, Shriver MD, Ahaghotu CA, Kittles RA.

Hum Genet. 2006 Aug;120(1):69-76. Epub 2006 May 30.

PMID 16733712

Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer.

Berndt U, Philipsen L, Bartsch S, Wiedenmann B, Baumgart DC, Hammerle M, Sturm A.

Cancer Res. 2008 Feb 1;68(3):880-8.

PMID 18245490

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Last year publications	automatic search in PubMed

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Contributor(s)

Written	07-2008	Masakazu Yashiro
		The Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan

Citation

This paper should be referenced as such :

Yashiro M . ICAM1 (intercellular adhesion molecule 1 (CD54), human rhinovirus receptor). Atlas Genet Cytogenet Oncol Haematol. July 2008 . URL : http://AtlasGeneticsOncology.org/Genes/ICAM1ID40909ch19p13.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Dec 6 17:56:21 2008