LCP1 (lymphocyte cytosolic protein1)

Identity

Other names	L-Plastine
Hugo	LCP1
Location	13q14

DNA/RNA

Description	spans on a 90 kb genomic fragment; 16 exons, large first intron (20kb)
Transcription	3.7 kb mRNA; coding sequence from exon 2 to exon 16: 3500 bp

Protein

Description	570 amino acids
Expression	restricted to the hematopoietic cells (leukocytes); expression induced in all tumor cells of all tissues
Localisation	membrane
Homology	belongs to an actin-binding protein family (T-Plastin, Fimbrin, I-Plastin)

Implicated in

Entity	t(3;13)(q27;q14)/ NHL --> LCP1 - BCL6
Disease	non Hodgkin follicular as well as Burkitt lymphomas
Cytogenetics	t(3;13) is observed as a secondary anomaly
Hybrid/Mutated Gene	both 5' L-Plastin- 3' BCL6 and 5' BCL6 - 3' L-Plastin, leading to two fusion transcripts
Abnormal Protein	no fusion protein, but promoter exchange between both partner genes

External links

	Nomenclature
Hugo	LCP1
GDB	LCP1
Entrez_Gene	LCP1  3936  lymphocyte cytosolic protein 1 (L-plastin)
	Cards
Atlas	LCP1ID95
GeneCards	LCP1
Ensembl	LCP1 [Search_View]   ENSG00000136167 [Gene_View]
Genatlas	LCP1
GeneLynx	LCP1
eGenome	LCP1
euGene	3936
	Genomic and cartography
GoldenPath	LCP1  -  13q14   chr13:45598060-45654395 -  13q14.3   [Description]    (hg18-Mar_2006)
Ensembl	LCP1 - 13q14.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	LCP1
	Gene and transcription
Genbank	AB208984 [ ENTREZ ]
Genbank	AK058152 [ ENTREZ ]
Genbank	AK097275 [ ENTREZ ]
Genbank	AK129625 [ ENTREZ ]
Genbank	AK223305 [ ENTREZ ]
RefSeq	NM_002298 [ SRS ]    NM_002298 [ ENTREZ ]
RefSeq	AC_000056 [ SRS ]    AC_000056 [ ENTREZ ]
RefSeq	NC_000013 [ SRS ]    NC_000013 [ ENTREZ ]
RefSeq	NT_024524 [ SRS ]    NT_024524 [ ENTREZ ]
RefSeq	NW_925473 [ SRS ]    NW_925473 [ ENTREZ ]
AceView	LCP1 AceView - NCBI
Unigene	Hs.381099 [ SRS ]    Hs.381099 [ NCBI ]     HS381099 [ spliceNest ]
Fast-db	4887 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P13796 [ SRS]    P13796 [ EXPASY ]     P13796 [ INTERPRO ]
Prosite	PS00019 ACTININ_1 [ SRS ]    PS00019 ACTININ_1 [ Expasy ]
Prosite	PS00020 ACTININ_2 [ SRS ]    PS00020 ACTININ_2 [ Expasy ]
Prosite	PS50021 CH [ SRS ]    PS50021 CH [ Expasy ]
Prosite	PS00018 EF_HAND_1 [ SRS ]    PS00018 EF_HAND_1 [ Expasy ]
Prosite	PS50222 EF_HAND_2 [ SRS ]    PS50222 EF_HAND_2 [ Expasy ]
Interpro	IPR001589 Actinin_actin-bd_CS [ SRS ]    IPR001589 Actinin_actin-bd_CS [ EBI ]
Interpro	IPR001715 Calponin_act_bd [ SRS ]    IPR001715 Calponin_act_bd [ EBI ]
Interpro	IPR011992 EF-Hand_type [ SRS ]    IPR011992 EF-Hand_type [ EBI ]
Interpro	IPR002048 EF_hand_Ca_bd [ SRS ]    IPR002048 EF_hand_Ca_bd [ EBI ]
CluSTr	P13796
Pfam	PF00307 CH [ SRS ]    PF00307 CH [ Sanger ]    pfam00307 [ NCBI-CDD ]
Pfam	PF00036 efhand [ SRS ]    PF00036 efhand [ Sanger ]    pfam00036 [ NCBI-CDD ]
Smart	SM00033 CH [EMBL]
Smart	SM00054 EFh [EMBL]
Prodom	PD000012 EF-hand[INRA-Toulouse]
Prodom	P13796 PLSL_HUMAN [ Domain structure ]   P13796 PLSL_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P13796
PDB	2D85 [ SRS ]    2D85 [ PdbSum ],   2D85 [ IMB ]   2D85 [ RSDB ]
HPRD	01082
	Protein Interaction databases
DIP	P13796
IntAct	P13796
	Polymorphism : SNP, mutations, diseases
OMIM	153430    [ map ]
GENECLINICS	153430
SNP	LCP1 [dbSNP-NCBI]
SNP	NM_002298 [SNP-NCI]
SNP	LCP1 [GeneSNPs - Utah]  LCP1] [HGBASE - SRS]
HAPMAP	LCP1 [HAPMAP]
COSMIC	LCP1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	LCP1
	General knowledge
Family Browser	LCP1 [UCSC Family Browser]
SOURCE	NM_002298
SMD	Hs.381099
SAGE	Hs.381099
GO	ruffle [Amigo]  ruffle
GO	phagocytic cup [Amigo]  phagocytic cup
GO	actin binding [Amigo]  actin binding
GO	calcium ion binding [Amigo]  calcium ion binding
GO	calcium ion binding [Amigo]  calcium ion binding
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	actin filament [Amigo]  actin filament
GO	biological_process [Amigo]  biological_process
GO	identical protein binding [Amigo]  identical protein binding
GO	actin filament binding [Amigo]  actin filament binding
GO	actin filament bundle formation [Amigo]  actin filament bundle formation
PubGene	LCP1
TreeFam	LCP1
CTD	3936 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	LCP1 Related clones (RZPD - Berlin)
	PubMed
PubMed	34 Pubmed reference(s) in LocusLink

Bibliography

Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts.

Lin CS, Aebersold RH, Kent SB, Varma M, Leavitt J

Molecular and cellular biology. 1988 ; 8 (11) : 4659-4668.

PMID 3211125

Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells.

Lin CS, Park T, Chen ZP, Leavitt J

The Journal of biological chemistry. 1993 ; 268 (4) : 2781-2792.

PMID 8428952

Activation of the leukocyte plastin gene occurs in most human cancer cells.

Park T, Chen ZP, Leavitt J

Cancer research. 1994 ; 54 (7) : 1775-1781.

PMID 8137292

Interaction of a Dictyostelium member of the plastin/fimbrin family with actin filaments and actin-myosin complexes.

Prassler J, Stocker S, Marriott G, Heidecker M, Kellermann J, Gerisch G

Molecular biology of the cell. 1997 ; 8 (1) : 83-95.

PMID 9017597

Cytogenetics in multiple myeloma: a multicenter study of 24 patients with t(11;14)(q13;q32) or its variant.

LaˆØ JL, Michaux L, Dastugue N, Vasseur F, Daudignon A, Facon T, Bauters F, Zandecki M

Cancer genetics and cytogenetics. 1998 ; 104 (2) : 133-138.

PMID 9666807

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	03-1998	Sylvie Galiègue-Zouitina
		U.124 INSERM, I.R.C.L., Place de Verdun, 59045 LILLE Cedex, France

Citation

This paper should be referenced as such :

Galiègue-Zouitina S . LCP1 (lymphocyte cytosolic protein1). Atlas Genet Cytogenet Oncol Haematol. March 1998 . URL : http://AtlasGeneticsOncology.org/Genes/LCP1ID95.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Jul 2 08:24:38 2008