| Identity |
| Other names | L-Plastine |
| HGNC (Hugo) | LCP1 |
| Location | 13q14 |
| Location_base_pair | Starts at 45598060 and ends at 45654460 bp from pter ( according to hg18-Mar_2006) [Mapping] |
| DNA/RNA |
| Description | spans on a 90 kb genomic fragment; 16 exons, large first intron (20kb) |
| Transcription | 3.7 kb mRNA; coding sequence from exon 2 to exon 16: 3500 bp |
| Protein |
| Description | 570 amino acids |
| Expression | restricted to the hematopoietic cells (leukocytes); expression induced in all tumor cells of all tissues |
| Localisation | membrane |
| Homology | belongs to an actin-binding protein family (T-Plastin, Fimbrin, I-Plastin) |
| Implicated in |
| Entity | t(3;13)(q27;q14)/ NHL --> LCP1 - BCL6 |
| Disease | non Hodgkin follicular as well as Burkitt lymphomas |
| Cytogenetics | t(3;13) is observed as a secondary anomaly |
| Hybrid/Mutated Gene | both 5' L-Plastin- 3' BCL6 and 5' BCL6 - 3' L-Plastin, leading to two fusion transcripts |
| Abnormal Protein | no fusion protein, but promoter exchange between both partner genes |
| External links |
| Bibliography |
| Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts. |
| Lin CS, Aebersold RH, Kent SB, Varma M, Leavitt J |
| Molecular and cellular biology. 1988 ; 8 (11) : 4659-4668. |
| PMID 3211125 |
| Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. |
| Lin CS, Park T, Chen ZP, Leavitt J |
| The Journal of biological chemistry. 1993 ; 268 (4) : 2781-2792. |
| PMID 8428952 |
| Activation of the leukocyte plastin gene occurs in most human cancer cells. |
| Park T, Chen ZP, Leavitt J |
| Cancer research. 1994 ; 54 (7) : 1775-1781. |
| PMID 8137292 |
| Interaction of a Dictyostelium member of the plastin/fimbrin family with actin filaments and actin-myosin complexes. |
| Prassler J, Stocker S, Marriott G, Heidecker M, Kellermann J, Gerisch G |
| Molecular biology of the cell. 1997 ; 8 (1) : 83-95. |
| PMID 9017597 |
| Cytogenetics in multiple myeloma: a multicenter study of 24 patients with t(11;14)(q13;q32) or its variant. |
| LaˆØ JL, Michaux L, Dastugue N, Vasseur F, Daudignon A, Facon T, Bauters F, Zandecki M |
| Cancer genetics and cytogenetics. 1998 ; 104 (2) : 133-138. |
| PMID 9666807 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 03-1998 | Sylvie Galiègue-Zouitina |
| U.124 INSERM, I.R.C.L., Place de Verdun, 59045 LILLE Cedex, France |
| Citation |
| This paper should be referenced as such : |
| Galiègue-Zouitina S . LCP1 (lymphocyte cytosolic protein1). Atlas Genet Cytogenet Oncol Haematol. March 1998 . URL : http://AtlasGeneticsOncology.org/Genes/LCP1ID95.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Feb 6 13:40:15 CET 2010 |
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