| Entity | Solitary lipomas. |
| Disease | Benign tumors of adipose tissue |
| Prognosis | Can be surgically removed with no recurrence in most cases. |
| Cytogenetics | More than 60% of solitary lipomas have an aberrant karyotype: 2/3 of these carry 12q15 rearrangements, most often translocations, affecting the HMGA2 gene:
1/4 of the latter have chromosomal region 3q27-q28 (containing LPP) as 12q15 translocation partner (creating a HMGA2/LPP fusion gene).
In the 3/4 others, multiple chromosomes have been found as translocation partner of 12q15, one of these being chromosomal region 13q12 (containing, amongst others, the LHFP gene).
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| Hybrid/Mutated Gene | HMGA2/LHFP hybrid gene containing the first three exons of HMGA2, which are followed by exon(s) of LHFP; under the regulation of the HMGA2 promoter. |
| Abnormal Protein | No known LHFP fusion protein. (HMGA2/LHFP fusion transcripts encode the three DNA-binding domains of HMGA2 followed by 69 amino acids encoded by frame-shifted LHFP sequences). |
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| LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes. |
| Petit MM, Schoenmakers EF, Huysmans C, Geurts JM, Mandahl N, Van de Ven WJ |
| Genomics. 1999 ; 57 (3) : 438-441. |
| PMID 10329012 |
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| Absence of HMGIC-LHFP fusion in pulmonary chondroid hamartomas with aberrations involving chromosomal regions 12q13 through 15 and 13q12 through q14. |
| Rogalla P, Lemke I, Bullerdiek J |
| Cancer genetics and cytogenetics. 2002 ; 133 (1) : 90-93. |
| PMID 11890997 |
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| Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors. |
| DahlŠn A, Debiec-Rychter M, Pedeutour F, Domanski HA, Hglund M, Bauer HC, Rydholm A, Sciot R, Mandahl N, Mertens F |
| International journal of cancer. Journal international du cancer. 2003 ; 103 (5) : 616-623. |
| PMID 12494468 |
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