| Entity | t(11;18)(q21;q21) / marginal zone B-cell lymphoma ofMALT-type --> BIRC3 - MALT1 |
| Disease | B-cell non Hodgkin lymphoma (NHL); marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT); found in extranodal MZBCL or MALT-type (50%), absent in splenic and nodal MZBCL |
| Prognosis | For gastric MALT-type lymphomas, t(11;18) is a clonal marker for resistance to Helicobacter pylori eradication therapy and antigen independent growth |
| Cytogenetics | t(11;18) is frequently associated with deletions affecting 3' API2 on chromosome 11 or 5' MALT1 on chromosome 18. |
| |  |
| |
| BIRC3/MALT1 fusion protein - Baens Mathijs, Peter Marynen |
| |
| Hybrid/Mutated Gene | 5' API2 on chromosome 11q21 translocated on chromosome 18 in frame with 3' MALT1. Deletions often exclude the expression of the reciprocal 5' MLT API2 3' transcript. |
| Abnormal Protein | All MALT-type lymphomas reported with a t(11;18) express an Œin frame' API2-MLT fusion protein with consistently the three BIR domains of API2 fused to the caspace p20 domain and VDJ4-like domain of MLT. |
| Oncogenesis | Transient expression of the API2-MLT fusion protein acitvates an NF-KB luciferase reporter construct, suggesting the involvement of this signaling cascade in MALT lymphomagenesis |
| | |
| A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. |
| Akagi T, Motegi M, Tamura A, Suzuki R, Hosokawa Y, Suzuki H, Ota H, Nakamura S, Morishima Y, Taniwaki M, Seto M |
| Oncogene. 1999 ; 18 (42) : 5785-5794. |
| PMID 10523859 |
| |
| The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. |
| Dierlamm J, Baens M, Wlodarska I, Stefanova-Ouzounova M, Hernandez JM, Hossfeld DK, De Wolf-Peeters C, Hagemeijer A, Van den Berghe H, Marynen P |
| Blood. 1999 ; 93 (11) : 3601-3609. |
| PMID 10339464 |
| |
| The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation. |
| Baens M, Maes B, Steyls A, Geboes K, Marynen P, De Wolf-Peeters C |
| The American journal of pathology. 2000 ; 156 (4) : 1433-1439. |
| PMID 10751367 |
| |
| The product of the t(11;18), an API2-MLT fusion, is an almost exclusive finding in marginal zone cell lymphoma of extranodal MALT-type. |
| Maes B, Baens M, Marynen P, De Wolf-Peeters C |
| Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2000 ; 11 (5) : 521-526. |
| PMID 10907943 |
| |
| Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLT specific probes. |
| Dierlamm J, Baens M, Stefanova-Ouzounova M, Hinz K, Wlodarska I, Maes B, Steyls A, Driessen A, Verhoef G, Gaulard P, Hagemeijer A, Hossfeld DK, De Wolf-Peeters C, Marynen P |
| Blood. 2000 ; 96 (6) : 2215-2218. |
| PMID 10979968 |
| |
| Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. |
| Baens M, Steyls A, Dierlamm J, De Wolf-Peeters C, Marynen P |
| Genes, chromosomes & cancer. 2000 ; 29 (4) : 281-291. |
| PMID 11066071 |
| |
| Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. |
| Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV, Dixit VM |
| Molecular cell. 2000 ; 6 (4) : 961-967. |
| PMID 11090634 |
| |
