MDS2

Identity

HGNC	MDS2
Location	1p36
Location_base_pair	Starts at 23826410 and ends at 23839643 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

Description	spans 13 kb; 7 exons
Transcription	4 alternate splicings; major splice: 281 bp, exons 1, 4, 6, 7 are constantly used

Protein

Description	The 4 alternate splicings give rise to 2 proteins, of 82 and 140 amino acids
Expression	wide

Implicated in

Entity	t(1;12)(p36;p13) in myeloid disorders
Prognosis	unknown so far
Hybrid/Mutated Gene	5' ETV6 - 3' MDS2
Abnormal Protein	truncated ETV6

External links

	Nomenclature
HGNC	MDS2   29633
Entrez_Gene	MDS2  259283  myelodysplastic syndrome 2 translocation associated
	Cards
Atlas	MDS2ID476
GeneCards	MDS2
Ensembl	MDS2 [Search_View]   ENSG00000038219 [Gene_View]  MDS2 [Vega]
Genatlas	MDS2
GeneLynx	MDS2
eGenome	MDS2
euGene	259283
	Genomic and cartography
GoldenPath	MDS2  -  1p36   chr1:23826410-23839643 +  1p36   [Description]    (hg18-Mar_2006)
Ensembl	MDS2 - 1p36 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	MDS2
	Gene and transcription
Genbank	AJ310434 [ ENTREZ ]
Genbank	BC041472 [ ENTREZ ]
CCDS	MDS2 CCDS - NCBI
AceView	MDS2 AceView - NCBI
Unigene	Hs.523369 [ SRS ]    Hs.523369 [ NCBI ]     HS523369 [ spliceNest ]
	Protein : pattern, domain, 3D structure
SwissProt	Q8NDY4 [ SRS]    Q8NDY4 [ EXPASY ]     Q8NDY4 [ INTERPRO ]     Q8NDY4 [ UNIPROT ] Q8NDY4 [ VarSplice ]
CluSTr	Q8NDY4
Blocks	Q8NDY4
	Protein Interaction databases
DIP	Q8NDY4
IntAct	Q8NDY4
	Polymorphism : SNP, mutations, diseases
OMIM	607305    [ map ]
GENECLINICS	607305
SNP	MDS2 [dbSNP-NCBI]
SNP	MDS2 [GeneSNPs - Utah]  MDS2] [HGBASE - SRS]
HAPMAP	MDS2 [HAPMAP]
COSMIC	MDS2 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	MDS2 [Translocation breakpoints In Cancer]
HGMD	MDS2
Genetic Association	MDS2
CDC HuGE	MDS2
	General knowledge
Family Browser	MDS2 [UCSC Family Browser]
SMD	Hs.523369
SAGE	Hs.523369
PubGene	MDS2
TreeFam	MDS2
CTD	259283 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	MDS2 Related clones (RZPD - Berlin)
	PubMed
PubMed	3 Pubmed reference(s) in Entrez

Bibliography

A novel gene, MDS2, is fused to ETV6/TEL in a t(1;12)(p36.1;p13) in a patient with myelodysplastic syndrome.

Odero MD, Vizmanos JL, Romˆ°n JP, Lahortiga I, Panizo C, Calasanz MJ, Zeleznik-Le NJ, Rowley JD, Novo FJ

Genes, chromosomes & cancer. 2002 ; 35 (1) : 11-19.

PMID 12203785

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	07-2003	Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :

Huret JL, Senon S . MDS2. Atlas Genet Cytogenet Oncol Haematol. July 2003 . URL : http://AtlasGeneticsOncology.org/Genes/MDS2ID476.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sun Nov 9 19:43:20 2008