MLF1 (myelodysplasia/myeloid leukemia factor 1)

Identity

HGNC	MLF1
Location	3q25
Local_order	EVI1/MDS1 is more telomeric (in 3q26), BCL6 even more in 3q27

DNA/RNA

Transcription

alternate splicing: 1.4 and 2.4 kb

Protein

Description	267 amino acids; 31 KDa; do not contain known functional motifs
Expression	MLF1 transcripts widely expressed (gonads, muscle, heart, kidney, colon)
Localisation	cytoplasmic localisation
Homology	none is known, apart from MLF2 (40% homology)

Implicated in

Entity	t(3;5)(q25;q34)/ANLL or MDS--> NPM1 - MLF1
Disease	ANLL, MDS, BC-CML; trilineage involvement
Prognosis	very poor
Cytogenetics	location of breakpoints difficult to ascertain
Hybrid/Mutated Gene	5' NPM1-3' MLF1 on der(5)
Abnormal Protein	nuclear protein

External links

	Nomenclature
HGNC	MLF1   7125
Entrez_Gene	MLF1  4291  myeloid leukemia factor 1
	Cards
Atlas	MLF1
GeneCards	MLF1
Ensembl	MLF1 [Search_View]   ENSG00000178053 [Gene_View]
Genatlas	MLF1
GeneLynx	MLF1
eGenome	MLF1
euGene	4291
	Genomic and cartography
GoldenPath	MLF1  -  3q25   chr3:159771647-159806946 +  3q25   [Description]    (hg18-Mar_2006)
Ensembl	MLF1 - 3q25 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	MLF1
	Gene and transcription
Genbank	AA707847 [ ENTREZ ]
Genbank	AK056948 [ ENTREZ ]
Genbank	AK096889 [ ENTREZ ]
Genbank	AK297488 [ ENTREZ ]
Genbank	AK315402 [ ENTREZ ]
RefSeq	NM_001130156 [ SRS ]    NM_001130156 [ ENTREZ ]
RefSeq	NM_001130157 [ SRS ]    NM_001130157 [ ENTREZ ]
RefSeq	NM_022443 [ SRS ]    NM_022443 [ ENTREZ ]
RefSeq	AC_000046 [ SRS ]    AC_000046 [ ENTREZ ]
RefSeq	AC_000135 [ SRS ]    AC_000135 [ ENTREZ ]
RefSeq	NC_000003 [ SRS ]    NC_000003 [ ENTREZ ]
RefSeq	NT_005612 [ SRS ]    NT_005612 [ ENTREZ ]
RefSeq	NW_001838884 [ SRS ]    NW_001838884 [ ENTREZ ]
RefSeq	NW_921807 [ SRS ]    NW_921807 [ ENTREZ ]
AceView	MLF1 AceView - NCBI
Unigene	Hs.85195 [ SRS ]    Hs.85195 [ NCBI ]     HS85195 [ spliceNest ]
Fast-db	14322 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P58340 [ SRS]    P58340 [ EXPASY ]     P58340 [ INTERPRO ]     P58340 [ UNIPROT ]
CluSTr	P58340
Blocks	P58340
HPRD	03239
	Protein Interaction databases
DIP	P58340
IntAct	P58340
	Polymorphism : SNP, mutations, diseases
OMIM	601402;601626    [ map ]
GENECLINICS	601402;601626
SNP	MLF1 [dbSNP-NCBI]
SNP	NM_001130156 [SNP-NCI]
SNP	NM_001130157 [SNP-NCI]
SNP	NM_022443 [SNP-NCI]
SNP	MLF1 [GeneSNPs - Utah]  MLF1] [HGBASE - SRS]
HAPMAP	MLF1 [HAPMAP]
COSMIC	MLF1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	MLF1
	General knowledge
Family Browser	MLF1 [UCSC Family Browser]
SOURCE	NM_001130156
SOURCE	NM_001130157
SOURCE	NM_022443
SMD	Hs.85195
SAGE	Hs.85195
GO	myeloid progenitor cell differentiation [Amigo]  myeloid progenitor cell differentiation
GO	DNA binding [Amigo]  DNA binding
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	transcription [Amigo]  transcription
GO	cell cycle [Amigo]  cell cycle
GO	cell cycle arrest [Amigo]  cell cycle arrest
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	protein domain specific binding [Amigo]  protein domain specific binding
GO	cell differentiation [Amigo]  cell differentiation
PubGene	MLF1
TreeFam	MLF1
CTD	4291 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	MLF1 Related clones (RZPD - Berlin)
	PubMed
PubMed	12 Pubmed reference(s) in LocusLink

Bibliography

The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.

Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW

Oncogene. 1996 ; 12 (2) : 265-275.

PMID 8570204

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	12-1997	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . MLF1 (myelodysplasia/myeloid leukemia factor 1). Atlas Genet Cytogenet Oncol Haematol. December 1997 . URL : http://AtlasGeneticsOncology.org/Genes/MLF1.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:15:22 2008