STARD3 (START domain containing 3)

Identity

Other names	MLN64
	CAB1
HGNC	STARD3
Location	17q12-21
Location_base_pair	Starts at 35046938 and ends at 35073250 bp from pter ( according to hg18-Mar_2006).
Local_order	from centromere to telomere are: TRAF4 (alias MLN62/CART1), Lasp1 (alias MLN50), c-erbB2, and MLN64

DNA/RNA

Transcription

cDNA: 2.1 kb; coding sequence: 1335 bp

Protein

Description	445 amino acids; 50 kDa; contains four putative transmembrane domains at its N-terminal part; posseses a StAR Homology Domain at its C-terminal part
Homology	with StAR (Steroidogenic Acute Regulatory protein)

Implicated in

Entity	breast carcinomas
Disease	17q11-q21 amplification is found in about 25% of primary breast carcinomas
Prognosis	poor clinical outcome; increase risk of relapse

External links

	Nomenclature
HGNC	STARD3   17579
Entrez_Gene	STARD3  10948  StAR-related lipid transfer (START) domain containing 3
	Cards
Atlas	MLN64ID202
GeneCards	STARD3
Ensembl	STARD3 [Search_View]   ENSG00000131748 [Gene_View]  STARD3 [Vega]
Genatlas	STARD3
GeneLynx	STARD3
eGenome	STARD3
euGene	10948
	Genomic and cartography
GoldenPath	STARD3  -     chr17:35046938-35073250 +  17q11-q12   [Description]    (hg18-Mar_2006)
Ensembl	STARD3 - 17q11-q12 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	STARD3
	Gene and transcription
Genbank	AB209772 [ ENTREZ ]
Genbank	AK123364 [ ENTREZ ]
Genbank	AK225069 [ ENTREZ ]
Genbank	AK300176 [ ENTREZ ]
Genbank	AK300842 [ ENTREZ ]
RefSeq	NM_006804 [ SRS ]    NM_006804 [ ENTREZ ]
RefSeq	AC_000060 [ SRS ]    AC_000060 [ ENTREZ ]
RefSeq	AC_000149 [ SRS ]    AC_000149 [ ENTREZ ]
RefSeq	NC_000017 [ SRS ]    NC_000017 [ ENTREZ ]
RefSeq	NT_010755 [ SRS ]    NT_010755 [ ENTREZ ]
RefSeq	NW_001838435 [ SRS ]    NW_001838435 [ ENTREZ ]
RefSeq	NW_926828 [ SRS ]    NW_926828 [ ENTREZ ]
CCDS	STARD3 CCDS - NCBI
AceView	STARD3 AceView - NCBI
Unigene	Hs.77628 [ SRS ]    Hs.77628 [ NCBI ]     HS77628 [ spliceNest ]
Fast-db	9555 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q14849 [ SRS]    Q14849 [ EXPASY ]     Q14849 [ INTERPRO ]     Q14849 [ UNIPROT ] Q14849 [ VarSplice ]
Prosite	PS50848 START [ SRS ]    PS50848 START [ Expasy ]
Interpro	IPR000799 StAR [ SRS ]    IPR000799 StAR [ EBI ]
Interpro	IPR002913 START_lipid_bd [ SRS ]    IPR002913 START_lipid_bd [ EBI ]
CluSTr	Q14849
Pfam	PF01852 START [ SRS ]    PF01852 START [ Sanger ]    pfam01852 [ NCBI-CDD ]
Smart	SM00234 START [EMBL]
Blocks	Q14849
PDB	1EM2 [ SRS ]    1EM2 [ PdbSum ],   1EM2 [ IMB ]   1EM2 [ RSDB ]
PDB	2I92 [ SRS ]    2I92 [ PdbSum ],   2I92 [ IMB ]   2I92 [ RSDB ]
HPRD	06132
	Protein Interaction databases
DIP	Q14849
IntAct	Q14849
	Polymorphism : SNP, mutations, diseases
OMIM	607048    [ map ]
GENECLINICS	607048
SNP	STARD3 [dbSNP-NCBI]
SNP	NM_006804 [SNP-NCI]
SNP	STARD3 [GeneSNPs - Utah]  STARD3] [HGBASE - SRS]
HAPMAP	STARD3 [HAPMAP]
HGMD	STARD3
Genetic Association	STARD3
CDC HuGE	STARD3
	General knowledge
Family Browser	STARD3 [UCSC Family Browser]
SOURCE	NM_006804
SMD	Hs.77628
SAGE	Hs.77628
GO	cytoplasm [Amigo]  cytoplasm
GO	endosome [Amigo]  endosome
GO	lipid metabolic process [Amigo]  lipid metabolic process
GO	steroid biosynthetic process [Amigo]  steroid biosynthetic process
GO	C21-steroid hormone biosynthetic process [Amigo]  C21-steroid hormone biosynthetic process
GO	mitochondrial transport [Amigo]  mitochondrial transport
GO	lipid transport [Amigo]  lipid transport
GO	cholesterol metabolic process [Amigo]  cholesterol metabolic process
GO	lipid binding [Amigo]  lipid binding
GO	cholesterol binding [Amigo]  cholesterol binding
GO	cholesterol binding [Amigo]  cholesterol binding
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	cholesterol transporter activity [Amigo]  cholesterol transporter activity
GO	late endosome membrane [Amigo]  late endosome membrane
PubGene	STARD3
TreeFam	STARD3
CTD	10948 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	STARD3 Related clones (RZPD - Berlin)
	PubMed
PubMed	26 Pubmed reference(s) in Entrez

Bibliography

Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.

Tomasetto C, Rˆ©gnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC

Genomics. 1995 ; 28 (3) : 367-376.

PMID 7490069

Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer.

Biˆ®che I, Tomasetto C, Rˆ©gnier CH, Moog-Lutz C, Rio MC, Lidereau R

Cancer research. 1996 ; 56 (17) : 3886-3890.

PMID 8752152

Isolation of a candidate gene, CAB1, for cholesterol transport to mitochondria from the c-ERBB-2 amplicon by a modified cDNA selection method.

Akiyama N, Sasaki H, Ishizuka T, Kishi T, Sakamoto H, Onda M, Hirai H, Yazaki Y, Sugimura T, Terada M

Cancer research. 1997 ; 57 (16) : 3548-3553.

PMID 9270027

MLN64 exhibits homology with the steroidogenic acute regulatory protein (STAR) and is over-expressed in human breast carcinomas.

Moog-Lutz C, Tomasetto C, Rˆ©gnier CH, Wendling C, Lutz Y, Muller D, Chenard MP, Basset P, Rio MC

International journal of cancer. Journal international du cancer. 1997 ; 71 (2) : 183-191.

PMID 9139840

MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis.

Watari H, Arakane F, Moog-Lutz C, Kallen CB, Tomasetto C, Gerton GL, Rio MC, Baker ME, Strauss JF 3rd

Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (16) : 8462-8467.

PMID 9237999

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	03-2000	Marie-Christine Rio

Citation

This paper should be referenced as such :

Rio MC . STARD3 (START domain containing 3). Atlas Genet Cytogenet Oncol Haematol. March 2000 . URL : http://AtlasGeneticsOncology.org/Genes/MLN64ID202.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sun Nov 9 19:43:41 2008