MN1 (meningioma 1)

Identity

HGNC	MN1
Location	22q11-12

DNA/RNA

Description	2 exons at least, the first being very CG rich and with CAG repeats; spans about 70 kb
Transcription	alternate splicing: 4.5 and 8 kb mRNA; coding sequence: 4.0 kb

Protein

Description	1319 and 1342 amino acids; glutamine and prolin rich (may function as transactivation domains)
Expression	ubiquitously expressed; high expression in muscle, low otherwise
Function	transcriptionnal regulator

Implicated in

Entity	t(12;22)(p13;q11) /myeloid malignancies --> MN1-ETV6
Disease	M4 ANLL and other myeloid malignancies (MDS ...)
Prognosis	yet uncertain; median survival 2yrs
Cytogenetics	additional anomalies: +8
Hybrid/Mutated Gene	5' MN1 - 3' ETV6
Abnormal Protein	N-term MN1 and most of it, comprising the glutamine/proline rich domain, fused to the DNA binding of ETV6 in C-term; nuclear protein
Oncogenesis	may act as an altered transcription factor
Entity	meningioma (some of them)

External links

	Nomenclature
HGNC	MN1   7180
Entrez_Gene	MN1  4330  meningioma (disrupted in balanced translocation) 1
	Cards
Atlas	MN1
GeneCards	MN1
Ensembl	MN1 [Search_View]   ENSG00000169184 [Gene_View]
Genatlas	MN1
GeneLynx	MN1
eGenome	MN1
euGene	4330
	Genomic and cartography
GoldenPath	MN1  -     chr22:26474265-26527486 -  22q12.1   [Description]    (hg18-Mar_2006)
Ensembl	MN1 - 22q12.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	MN1
	Gene and transcription
Genbank	BC152905 [ ENTREZ ]
Genbank	BC156879 [ ENTREZ ]
Genbank	CU013010 [ ENTREZ ]
Genbank	CU013298 [ ENTREZ ]
Genbank	X82209 [ ENTREZ ]
RefSeq	NM_002430 [ SRS ]    NM_002430 [ ENTREZ ]
RefSeq	AC_000065 [ SRS ]    AC_000065 [ ENTREZ ]
RefSeq	AC_000154 [ SRS ]    AC_000154 [ ENTREZ ]
RefSeq	NC_000022 [ SRS ]    NC_000022 [ ENTREZ ]
RefSeq	NT_011520 [ SRS ]    NT_011520 [ ENTREZ ]
RefSeq	NW_001838745 [ SRS ]    NW_001838745 [ ENTREZ ]
RefSeq	NW_927628 [ SRS ]    NW_927628 [ ENTREZ ]
AceView	MN1 AceView - NCBI
Unigene	Hs.268515 [ SRS ]    Hs.268515 [ NCBI ]     HS268515 [ spliceNest ]
Fast-db	3382 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q10571 [ SRS]    Q10571 [ EXPASY ]     Q10571 [ INTERPRO ]     Q10571 [ UNIPROT ]
CluSTr	Q10571
Blocks	Q10571
HPRD	08862
	Protein Interaction databases
DIP	Q10571
IntAct	Q10571
	Polymorphism : SNP, mutations, diseases
OMIM	156100;607174    [ map ]
GENECLINICS	156100;607174
SNP	MN1 [dbSNP-NCBI]
SNP	NM_002430 [SNP-NCI]
SNP	MN1 [GeneSNPs - Utah]  MN1] [HGBASE - SRS]
HAPMAP	MN1 [HAPMAP]
TICdb	MN1 [Translocation breakpoints In Cancer]
HGMD	MN1
	General knowledge
Family Browser	MN1 [UCSC Family Browser]
SOURCE	NM_002430
SMD	Hs.268515
SAGE	Hs.268515
GO	molecular_function [Amigo]  molecular_function
GO	cellular_component [Amigo]  cellular_component
GO	biological_process [Amigo]  biological_process
GO	negative regulation of cell cycle [Amigo]  negative regulation of cell cycle
PubGene	MN1
TreeFam	MN1
CTD	4330 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	MN1 Related clones (RZPD - Berlin)
	PubMed
PubMed	13 Pubmed reference(s) in LocusLink

Bibliography

Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.

Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, Geurts van Kessel A, Riegman P, Lekanne Deprez R, Zwarthoff E, Hagemeijer A

Oncogene. 1995 ; 10 (8) : 1511-1519.

PMID 7731705

Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma.

Lekanne Deprez RH, Riegman PH, Groen NA, Warringa UL, van Biezen NA, Molijn AC, Bootsma D, de Jong PJ, Menon AG, Kley NA

Oncogene. 1995 ; 10 (8) : 1521-1528.

PMID 7731706

Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma.

Lekanne Deprez RH, Riegman PH, Groen NA, Warringa UL, van Biezen NA, Molijn AC, Bootsma D, de Jong PJ, Menon AG, Kley NA

Oncogene. 1995 ; 10 (8) : 1521-1528.

PMID 7731706

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	10-1997	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . MN1 (meningioma 1). Atlas Genet Cytogenet Oncol Haematol. October 1997 . URL : http://AtlasGeneticsOncology.org/Genes/MN1.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:15:28 2008