| Identity |
| Other names | moesin (membrane-organising extension spike protein) |
| Hugo | MSN |
| Location | Xq11 |
| DNA/RNA |
| Transcription | 3879 bp mRNA with a 1733 bp of coding sequence |
| Protein |
| Description | 576 amino acids, 75 kDa; contains in N-term a globular membrane binding domain (band 4.1 like domain (amino acids 57 to 224), known also as the four-point-one/ezrin/radixin/moesin domai, an alpha helix domain, and in C-term a domain which interact with actin filaments |
| Expression | wide; expressed differentially in microvilli and cell adhesion sites |
| Function | cytoskeleton protein; binds to the plasma membrane and interacts with actin/myosin; role in cell-cell recognition and signaling |
| Homology | Ezrin, radixin, moesin are called the ERM proteins; they are members ofthe band 4.1 superfamily |
| Implicated in |
| Entity | t(X;2)(q11;p23) --> MSN- ALK |
| Disease | found in a case of ALK+ anaplasic large cell lymphoma |
| Abnormal Protein | 1005 amino acids, 125 kDa; membrane restricted; ;448 N-term amino acid from MSN, containing the band 4.1 like domain and most of the alpha helix domain, fused to the 557 (instead of the usual 562) C-term amino acids from ALK (i.e. the cytoplasmic portion of ALK with the tyrosine kinase domain). |
| Oncogenesis | tyrosine kinase activity. |
| External links |
| Bibliography |
| Moesin: a member of the protein 4.1-talin-ezrin family of proteins. |
| Lankes WT, Furthmayr H |
| Proceedings of the National Academy of Sciences of the United States of America. 1991 ; 88 (19) : 8297-8301. |
| PMID 1924289 |
| Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells. |
| Berryman M, Franck Z, Bretscher A |
| Journal of cell science. 1993 ; 105 ( Pt 4) : 1025-1043. |
| PMID 8227193 |
| The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. |
| Chishti AH, Kim AC, Marfatia SM, Lutchman M, Hanspal M, Jindal H, Liu SC, Low PS, Rouleau GA, Mohandas N, Chasis JA, Conboy JG, Gascard P, Takakuwa Y, Huang SC, Benz EJ Jr, Bretscher A, Fehon RG, Gusella JF, Ramesh V, Solomon F, Marchesi VT, Tsukita S, Tsukita S, Hoover KB |
| Trends in biochemical sciences. 1998 ; 23 (8) : 281-282. |
| PMID 9757824 |
| Regulation of cortical structure by the ezrin-radixin-moesin protein family. |
| Bretscher A |
| Current opinion in cell biology. 1999 ; 11 (1) : 109-116. |
| PMID 10047517 |
| ERM proteins in cell adhesion and membrane dynamics. |
| Mangeat P, Roy C, Martin M |
| Trends in cell biology. 1999 ; 9 (5) : 187-192. |
| PMID 10322453 |
| Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins. |
| Tsukita S, Yonemura S |
| The Journal of biological chemistry. 1999 ; 274 (49) : 34507-34510. |
| PMID 10574907 |
| Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma. |
| Tort F, Pinyol M, Pulford K, Roncador G, Hernandez L, Nayach I, Kluin-Nelemans HC, Kluin P, Touriol C, Delsol G, Mason D, Campo E |
| Laboratory investigation; a journal of technical methods and pathology. 2001 ; 81 (3) : 419-426. |
| PMID 11310834 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 08-2001 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . MSN. Atlas Genet Cytogenet Oncol Haematol. August 2001 . URL : http://AtlasGeneticsOncology.org/Genes/MSNID363.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:06:24 2008 |
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