Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MTA1 (metastasis-associated gene 1)

Identity

HGNC MTA1
Location 14q32.3
Location_base_pair Starts at 104957231 and ends at 105008102 bp from pter ( according to hg18-Mar_2006).
Note MTA1 gene was identified as a novel candidate metastasis-associated gene involved in cancer metastasis by differential cDNA library screening using the 13762NF rat mammary adenocarcinoma metastatic system. Its human homologue, MTA1 was also identified.

DNA/RNA

Transcription About 2.7 k mRNA; Protein coding region of 714 amino acid residues.

Protein

 
  Motifs in putative amino acid sequence of MTA1.
A leucine zipper motif and a GATA-type zinc finger motif are found near the mid-portion of the protein. Between them, a SANT domain is found which is homologous to the DNA binding domain of the myb oncogene family. In the amino terminal 200 amino acid residues, there are two highly acidic regions characteristic of the acidic activation domains of many transcription factors. At the carboxyl-terminus is a proline rich stretch whose sequence matches the consensus sequence of the src-homology 3-binding motif. Three putative nuclear localization signals are also present in the sequence.
Description 715 amino acids; about 80 kDa.
Expression Found in almost all tissues; most abundantly expressed in testis.
Localisation Nucleus.
Function MTA1 protein physically interacts with histone deacetylase 1 and is included in a protein nucleosome remodeling complex, NuRD (nucleosome remodeling and histone deacetylation). This protein complex, containing histone deacetylase, plays an important role in histone deacetylation, alteration of chromatin structure and transcriptional control.
Homology MTA2, MTA3.

Implicated in

Disease Cancer invasion and metastasis as follows:
  • Overexpression of MTA1 mRNA is correlated with the depth of invasion and lymph node metastasis in gastric and colorectal carcinomas as well as in esophageal carcinomas. The correlation of overexpression of this gene is also reported in lung cancer, thymoma and prostate cancer.
  • Overexpression of MTA1 protein might be a useful predictor for poor prognosis of human esophageal squamous cell carcinomas.
  • Forced expression of the MTA1 protein in breast cancer cell line MCF-7 is accompanied by enhancement of the ability of cells to invade an artificial matrix and to grow in an anchorage-independent manner.
  • Increasing MTA1 expression enhances migration, invasion and anchorage-independent survival of immortalized human keratinocytes.
    •   

    External links

    Nomenclature
    HGNCMTA1   7410
    Entrez_GeneMTA1  9112  metastasis associated 1
    Cards
    AtlasMTA1ID41443ch14q32
    GeneCardsMTA1
    EnsemblMTA1 [Search_View]   ENSG00000182979 [Gene_View]  MTA1 [Vega]
    GenatlasMTA1
    GeneLynxMTA1
    eGenomeMTA1
    euGene9112
    Genomic and cartography
    GoldenPathMTA1  -  14q32.3   chr14:104957231-105008102 +  14q32.3   [Description]    (hg18-Mar_2006)
    EnsemblMTA1 - 14q32.3 [CytoView]
    NCBIMapview
    OMIMDisease map [OMIM]
    HomoloGeneMTA1
    Gene and transcription
    GenbankAB209348 [ ENTREZ ]
    GenbankAF508978 [ ENTREZ ]
    GenbankAW732089 [ ENTREZ ]
    GenbankBC006177 [ ENTREZ ]
    GenbankBC009443 [ ENTREZ ]
    RefSeqNM_004689 [ SRS ]    NM_004689 [ ENTREZ ]
    RefSeqAC_000057 [ SRS ]    AC_000057 [ ENTREZ ]
    RefSeqAC_000146 [ SRS ]    AC_000146 [ ENTREZ ]
    RefSeqNC_000014 [ SRS ]    NC_000014 [ ENTREZ ]
    RefSeqNT_026437 [ SRS ]    NT_026437 [ ENTREZ ]
    RefSeqNW_001838117 [ SRS ]    NW_001838117 [ ENTREZ ]
    RefSeqNW_925561 [ SRS ]    NW_925561 [ ENTREZ ]
    CCDSMTA1 CCDS - NCBI
    AceViewMTA1 AceView - NCBI
    UnigeneHs.525629 [ SRS ]    Hs.525629 [ NCBI ]     HS525629 [ spliceNest ]
    Fast-db7008 (alternative variants)
    Protein : pattern, domain, 3D structure
    SwissProtQ13330 [ SRS]    Q13330 [ EXPASY ]     Q13330 [ INTERPRO ]     Q13330 [ UNIPROT ] Q13330 [ VarSplice ]
    PrositePS51038 BAH [ SRS ]    PS51038 BAH [ Expasy ]
    PrositePS51156 ELM2 [ SRS ]    PS51156 ELM2 [ Expasy ]
    PrositePS00344 GATA_ZN_FINGER_1 [ SRS ]    PS00344 GATA_ZN_FINGER_1 [ Expasy ]
    PrositePS50114 GATA_ZN_FINGER_2 [ SRS ]    PS50114 GATA_ZN_FINGER_2 [ Expasy ]
    PrositePS51293 SANT [ SRS ]    PS51293 SANT [ Expasy ]
    InterproIPR001025 BAH [ SRS ]    IPR001025 BAH [ EBI ]
    InterproIPR000949 ELM2 [ SRS ]    IPR000949 ELM2 [ EBI ]
    InterproIPR014778 Myb_DNA-bd [ SRS ]    IPR014778 Myb_DNA-bd [ EBI ]
    InterproIPR001005 SANT_DNA-bd [ SRS ]    IPR001005 SANT_DNA-bd [ EBI ]
    InterproIPR000679 Znf_GATA [ SRS ]    IPR000679 Znf_GATA [ EBI ]
    CluSTrQ13330
    PfamPF01426 BAH [ SRS ]    PF01426 BAH [ Sanger ]    pfam01426 [ NCBI-CDD ]
    PfamPF01448 ELM2 [ SRS ]    PF01448 ELM2 [ Sanger ]    pfam01448 [ NCBI-CDD ]
    PfamPF00320 GATA [ SRS ]    PF00320 GATA [ Sanger ]    pfam00320 [ NCBI-CDD ]
    PfamPF00249 Myb_DNA-binding [ SRS ]    PF00249 Myb_DNA-binding [ Sanger ]    pfam00249 [ NCBI-CDD ]
    SmartSM00439 BAH [EMBL]
    SmartSM00717 SANT [EMBL]
    SmartSM00401 ZnF_GATA [EMBL]
    BlocksQ13330
    HPRD04633
    Protein Interaction databases
    DIPQ13330
    IntActQ13330
    Polymorphism : SNP, mutations, diseases
    OMIM603526    [ map ]   
    GENECLINICS603526
    SNPMTA1 [dbSNP-NCBI]  
    SNPNM_004689 [SNP-NCI]  
    SNPMTA1 [GeneSNPs - Utah]  MTA1] [HGBASE - SRS]
    HAPMAPMTA1 [HAPMAP]  
    HGMDMTA1
    Genetic AssociationMTA1
    CDC HuGEMTA1
    General knowledge
    Family BrowserMTA1 [UCSC Family Browser]
    SOURCENM_004689
    SMDHs.525629
    SAGEHs.525629
    GODNA binding [Amigo]  DNA binding
    GOtranscription factor activity [Amigo]  transcription factor activity
    GOnucleus [Amigo]  nucleus
    GOcytoplasm [Amigo]  cytoplasm
    GOregulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
    GOsignal transduction [Amigo]  signal transduction
    GOzinc ion binding [Amigo]  zinc ion binding
    GOsequence-specific DNA binding [Amigo]  sequence-specific DNA binding
    GOmetal ion binding [Amigo]  metal ion binding
    BIOCARTADownregulated of MTA-3 in ER-negative Breast Tumors    [Genes]
    PubGeneMTA1
    TreeFamMTA1
    CTD9112 [Comparative ToxicoGenomics Database]
    Other databases
    Probes
    ProbeMTA1 Related clones (RZPD - Berlin)
    PubMed
    PubMed49 Pubmed reference(s) in Entrez

    Bibliography

    A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses.
    Toh Y, Pencil SD, Nicolson GL
    The Journal of biological chemistry. 1994 ; 269 (37) : 22958-22963.
    PMID 8083195
     
    Overexpression of the MTA1 gene in gastrointestinal carcinomas: correlation with invasion and metastasis.
    Toh Y, Oki E, Oda S, Tokunaga E, Ohno S, Maehara Y, Nicolson GL, Sugimachi K
    International journal of cancer. Journal international du cancer. 1997 ; 74 (4) : 459-463.
    PMID 9291440
     
    NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.
    Xue Y, Wong J, Moreno GT, Young MK, Cˆ¥tˆ© J, Wang W
    Molecular cell. 1998 ; 2 (6) : 851-861.
    PMID 9885572
     
    Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas.
    Toh Y, Kuwano H, Mori M, Nicolson GL, Sugimachi K
    British journal of cancer. 1999 ; 79 (11-12) : 1723-1726.
    PMID 10206283
     
    Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides.
    Nawa A, Nishimori K, Lin P, Maki Y, Moue K, Sawada H, Toh Y, Fumitaka K, Nicolson GL
    Journal of cellular biochemistry. 2000 ; 79 (2) : 202-212.
    PMID 10967548
     
    Molecular analysis of a candidate metastasis-associated gene, MTA1: possible interaction with histone deacetylase 1.
    Toh Y, Kuninaka S, Endo K, Oshiro T, Ikeda Y, Nakashima H, Baba H, Kohnoe S, Okamura T, Nicolson GL, Sugimachi K
    Journal of experimental & clinical cancer research : CR. 2000 ; 19 (1) : 105-111.
    PMID 10840944
     
    Assignment of the human metastasis-associated gene 1 (MTA1) to human chromosome band 14q32.3 by fluorescence in situ hybridization.
    Cui Q, Takiguchi S, Matsusue K, Toh Y, Yoshida MA
    Cytogenetics and cell genetics. 2001 ; 93 (1-2) : 139-140.
    PMID 11474200
     
    Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor.
    Mazumdar A, Wang RA, Mishra SK, Adam L, Bagheri-Yarmand R, Mandal M, Vadlamudi RK, Kumar R
    Nature cell biology. 2001 ; 3 (1) : 30-37.
    PMID 11146623
     
    Expression of the MTA1 mRNA in thymoma patients.
    Sasaki H, Yukiue H, Kobayashi Y, Nakashima Y, Kaji M, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y
    Cancer letters. 2001 ; 174 (2) : 159-163.
    PMID 11689291
     
    Metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes.
    Mahoney MG, Simpson A, Jost M, Noˆ© M, Kari C, Pepe D, Choi YW, Uitto J, Rodeck U
    Oncogene. 2002 ; 21 (14) : 2161-2170.
    PMID 11948399
     
    Expression of the MTA1 mRNA in advanced lung cancer.
    Sasaki H, Moriyama S, Nakashima Y, Kobayashi Y, Yukiue H, Kaji M, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y
    Lung cancer (Amsterdam, Netherlands). 2002 ; 35 (2) : 149-154.
    PMID 11804687
     
    MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer.
    Fujita N, Jaye DL, Kajita M, Geigerman C, Moreno CS, Wade PA
    Cell. 2003 ; 113 (2) : 207-219.
    PMID 12705869
     
    Emerging roles of MTA family members in human cancers.
    Kumar R, Wang RA, Bagheri-Yarmand R
    Seminars in oncology. 2003 ; 30 (5 Suppl 16) : 30-37.
    PMID 14613024
     
    The role of metastasis-associated protein 1 in prostate cancer progression.
    Hofer MD, Kuefer R, Varambally S, Li H, Ma J, Shapiro GI, Gschwend JE, Hautmann RE, Sanda MG, Giehl K, Menke A, Chinnaiyan AM, Rubin MA
    Cancer research. 2004 ; 64 (3) : 825-829.
    PMID 14871807
     
    Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas.
    Toh Y, Ohga T, Endo K, Adachi E, Kusumoto H, Haraguchi M, Okamura T, Nicolson GL
    International journal of cancer. Journal international du cancer. 2004 ; 110 (3) : 362-367.
    PMID 15095300
     
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

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    Contributor(s)

    Written04-2005Yasushi Toh, Garth L Nicolson
    Department of Gastroenterological Surgery National Kyushu Cancer, Center Fukuoka, 811-1395, Japan

    Citation

    This paper should be referenced as such :
    Toh Y, Nicolson GL . MTA1 (metastasis-associated gene 1). Atlas Genet Cytogenet Oncol Haematol. April 2005 .
    URL : http://AtlasGeneticsOncology.org/Genes/MTA1ID41443ch14q32.html

    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Sun Nov 9 19:43:58 2008

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