MYEOV

Identity

Other names	OCIM
HGNC	MYEOV
Location	11q13
Local_order	350 kb centromeric of cyclin D1

Note	detected by application of the NIH/3T3 tumorigenicity assay. However MYEOV cDNA was not positive in NIH/3T3 assay.

DNA/RNA

Description	2 exons; 3.5 kb transcript represents unspliced mRNA.
Transcription	main transcript 2.8 kb (broad band because of alternative splice products); minor transcript 3.5 kb.; coding sequence 313 or 255 amino acids. In normal tissues hardly any expression detectable. High expression in a subset of multiple myeloma cell lines with a t(11;14)(q13;q32) and in breast tumors and esophageal squamous cell carcinomas with or without 11q13 amplification.

Protein

Description	313 or 255 amino acids; contains one RNP-1 motif and 6 regions that might function as a transmembrane domain. Leucine-rich stretch at C-terminal.
Expression	5Ô UTR inhibits efficient translation of the protein
Localisation	in endoplasmic reticulum and mitochondria.

Implicated in

Entity	t(11;14)(q13;q32)
Disease	subset of multiple myeloma cell lines with t(11;14)(q13;q32)
Cytogenetics	myeov overexpression due to juxtaposition to the 5' enhancer or the most telomeric 3' enhancer of the immunoglobulin heavy chain (IgH).
Entity	11q13 amplification and/or overexpression
Disease	breast cancer; esophageal squamous cell carcinomas.
Prognosis	MYEOV DNA amplification correlated with estrogen and progesterone receptor-positive cancer, invasive lobular carcinoma type and axillary nodal involvement. In contrast to Cyclin D1 amplification, no association with disease outcome could be found.

External links

	Nomenclature
HGNC	MYEOV   7563
Entrez_Gene	MYEOV  26579  myeloma overexpressed gene (in a subset of t(11;14) positive multiple myelomas)
	Cards
Atlas	MYEOVID395
GeneCards	MYEOV
Ensembl	MYEOV [Search_View]   ENSG00000172927 [Gene_View]
Genatlas	MYEOV
GeneLynx	MYEOV
eGenome	MYEOV
euGene	26579
	Genomic and cartography
GoldenPath	MYEOV  -  11q13   chr11:68818198-68821330 +  11q13.2   [Description]    (hg18-Mar_2006)
Ensembl	MYEOV - 11q13.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	MYEOV
	Gene and transcription
Genbank	AJ223366 [ ENTREZ ]
Genbank	AJ223366 [ ENTREZ ]
Genbank	AK026148 [ ENTREZ ]
Genbank	AK290121 [ ENTREZ ]
Genbank	BC011815 [ ENTREZ ]
RefSeq	NM_138768 [ SRS ]    NM_138768 [ ENTREZ ]
RefSeq	AC_000054 [ SRS ]    AC_000054 [ ENTREZ ]
RefSeq	AC_000143 [ SRS ]    AC_000143 [ ENTREZ ]
RefSeq	NC_000011 [ SRS ]    NC_000011 [ ENTREZ ]
RefSeq	NT_033903 [ SRS ]    NT_033903 [ ENTREZ ]
RefSeq	NW_001838026 [ SRS ]    NW_001838026 [ ENTREZ ]
RefSeq	NW_925106 [ SRS ]    NW_925106 [ ENTREZ ]
AceView	MYEOV AceView - NCBI
Unigene	Hs.523848 [ SRS ]    Hs.523848 [ NCBI ]     HS523848 [ spliceNest ]
Fast-db	11061 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q96EZ4 [ SRS]    Q96EZ4 [ EXPASY ]     Q96EZ4 [ INTERPRO ]     Q96EZ4 [ UNIPROT ]
CluSTr	Q96EZ4
Blocks	Q96EZ4
HPRD	16130
	Protein Interaction databases
DIP	Q96EZ4
IntAct	Q96EZ4
	Polymorphism : SNP, mutations, diseases
OMIM	605625    [ map ]
GENECLINICS	605625
SNP	MYEOV [dbSNP-NCBI]
SNP	NM_138768 [SNP-NCI]
SNP	MYEOV [GeneSNPs - Utah]  MYEOV] [HGBASE - SRS]
HAPMAP	MYEOV [HAPMAP]
HGMD	MYEOV
	General knowledge
Family Browser	MYEOV [UCSC Family Browser]
SOURCE	NM_138768
SMD	Hs.523848
SAGE	Hs.523848
PubGene	MYEOV
TreeFam	MYEOV
CTD	26579 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	MYEOV Related clones (RZPD - Berlin)
	PubMed
PubMed	8 Pubmed reference(s) in LocusLink

Bibliography

Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32).

Janssen JW, Vaandrager JW, Heuser T, Jauch A, Kluin PM, Geelen E, Bergsagel PL, Kuehl WM, Drexler HG, Otsuki T, Bartram CR, Schuuring E

Blood. 2000 ; 95 (8) : 2691-2698.

PMID 10753852

MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas.

Janssen JW, Imoto I, Inoue J, Shimada Y, Ueda M, Imamura M, Bartram CR, Inazawa J

Journal of human genetics. 2002 ; 47 (9) : 460-464.

PMID 12202983

MYEOV: a candidate gene for DNA amplification events occurring centromeric to CCND1 in breast cancer.

Janssen JW, Cuny M, Orsetti B, Rodriguez C, Vallˆ©s H, Bartram CR, Schuuring E, Theillet C

International journal of cancer. Journal international du cancer. 2002 ; 102 (6) : 608-614.

PMID 12448002

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	12-2002	Johannes W.G. Janssen
		Janssen Institut für Humangenetik Universitätsklinikum Heidelberg Im Neuenheimer Feld 328 D-69120 Heidelberg, Germany

Citation

This paper should be referenced as such :

Janssen JWG . MYEOV. Atlas Genet Cytogenet Oncol Haematol. December 2002 . URL : http://AtlasGeneticsOncology.org/Genes/MYEOVID395.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:15:41 2008