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PRDX1 (peroxiredoxin 1)

Identity

Other namesPAGA (Proliferation Associated Gene A)
PAG
PRX1
Hs.1163
NKEFA (natural killer-enhancing factor A)
Prx-1 (peroxiredoxin 1)
HBP23 (Heme-binding protein 23 kDa)
MSP23 (macrophage 23-kD stress protein)
HGNC PRDX1
Location 1p34.1
Location_base_pair Starts at 45749294 and ends at 45760196 bp from pter ( according to hg18-Mar_2006).
Note PAGA/NKEFA/PRDX1/peroxiredoxin 1, located in 1p34, is often confused in databases and elsewhere with PAGB/TDPX2, a pseudogene located in 9p22; PAGB is not either NKEFB/PRDX2/peroxiredoxin 2, located in 13q12; the other peroxiredoxins, PRDX3 and PRDX5, are located in 10q25-26 and in 11q13 respectively

DNA/RNA

Description 6 exons, 13 kb
Transcription 937 bp mRNA; 599 bp coding sequence
Pseudogene pseudogene in 9p22

Protein

Description 199 amino acids; 22 kDa; form dimers through a disulfide bridge
Expression widely expressed, in particular in the various cell types of the central nervous system and in red blood cells; overexpressed following induction of proliferation and oxidative stress
Localisation cytosolic
Function antioxidant, against oxidative stress; Abl SH3-binding protein; inhibitor of c-Abl tyrosine kinase activity; also binds to heme
Homology thioperoxiredoxines

Implicated in

Disease Correlations between the expression level and the stage of tumor progrssion in squamous cell carcinoma of the oral cavity; high expression in follicular thyroid tumors, but not in papillary carcinoma of the thyroid
  

External links

Nomenclature
HGNCPRDX1   9352
Entrez_GenePRDX1  5052  peroxiredoxin 1
Cards
AtlasPAGID266
GeneCardsPRDX1
EnsemblENSG00000117450 [Gene_View]  PRDX1 [Vega]
GenatlasPRDX1
Genomic and cartography
GoldenPathPRDX1  -  1p34.1   chr1:45749294-45760196 -  1p34.1   [Description]    (hg18-Mar_2006)
EnsemblPRDX1 - 1p34.1 [CytoView]
NCBIMapview
OMIM176763 Disease map [OMIM]
HomoloGenePRDX1
Gene and transcription
GenbankAI912389 [ ENTREZ ]
GenbankAK131049 [ ENTREZ ]
GenbankAK311898 [ ENTREZ ]
GenbankAV691526 [ ENTREZ ]
GenbankBC007063 [ ENTREZ ]
RefSeqNM_002574 [ SRS ]    NM_002574 [ ENTREZ ]
RefSeqNM_181696 [ SRS ]    NM_181696 [ ENTREZ ]
RefSeqNM_181697 [ SRS ]    NM_181697 [ ENTREZ ]
RefSeqAC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeqAC_000133 [ SRS ]    AC_000133 [ ENTREZ ]
RefSeqNC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeqNT_032977 [ SRS ]    NT_032977 [ ENTREZ ]
RefSeqNW_001838578 [ SRS ]    NW_001838578 [ ENTREZ ]
RefSeqNW_921351 [ SRS ]    NW_921351 [ ENTREZ ]
CCDSPRDX1 CCDS - NCBI
AceViewPRDX1 AceView - NCBI
UnigeneHs.180909 [ SRS ]    Hs.180909 [ NCBI ]
Fast-db15679 (alternative variants)
Protein : pattern, domain, 3D structure
SwissProtQ06830 [ SRS]    Q06830 [ EXPASY ]     Q06830 [ INTERPRO ]     Q06830 [ UNIPROT ] Q06830 [ VarSplice FASTA ]
PrositePS51352 THIOREDOXIN_2 [ SRS ]    PS51352 THIOREDOXIN_2 [ Expasy ]
InterproIPR000866 AhpC-TSA [ SRS ]    IPR000866 AhpC-TSA [ EBI ]
InterproIPR012335 Thioredoxin_fold [ SRS ]    IPR012335 Thioredoxin_fold [ EBI ]
CluSTrQ06830
PfamPF00578 AhpC-TSA [ SRS ]    PF00578 AhpC-TSA [ Sanger ]    pfam00578 [ NCBI-CDD ]
BlocksQ06830
PDB2RII [ SRS ]    2RII [ PdbSum ],   2RII [ IMB ]   2RII [ RSDB ]
HPRD01458
Protein Interaction databases
DIPQ06830
IntActQ06830
Polymorphism : SNP, mutations, diseases
OMIM176763    [ map ]   
GENETests176763
SNPPRDX1 [dbSNP-NCBI]  
SNPNM_002574 [SNP-NCI]  
SNPNM_181696 [SNP-NCI]  
SNPNM_181697 [SNP-NCI]  
SNPPRDX1 [GeneSNPs - Utah]  PRDX1] [HGBASE - SRS]
HAPMAPPRDX1 [HAPMAP]  
HGMDPRDX1
Genetic AssociationPRDX1
CDC HuGEPRDX1
General knowledge
Family BrowserPRDX1 [UCSC Family Browser]
SOURCENM_002574
SOURCENM_181696
SOURCENM_181697
SMDHs.180909
SAGEHs.180909
Enzyme1.11.1.15 [ Enzyme-Expasy ]   1.11.1.15 [ Enzyme-SRS ]   1.11.1.15 [ IntEnz-EBI ]   1.11.1.15 [ BRENDA ]   1.11.1.15 [ KEGG ]   
GOskeletal development [Amigo]  skeletal development
GOprotein binding [Amigo]  protein binding
GOnucleus [Amigo]  nucleus
GOcytoplasm [Amigo]  cytoplasm
GOcell proliferation [Amigo]  cell proliferation
GOoxidoreductase activity [Amigo]  oxidoreductase activity
GOmelanosome [Amigo]  melanosome
GOhydrogen peroxide catabolic process [Amigo]  hydrogen peroxide catabolic process
GOperoxiredoxin activity [Amigo]  peroxiredoxin activity
GOoxidation reduction [Amigo]  oxidation reduction
PubGenePRDX1
TreeFamPRDX1
CTD5052 [Comparative ToxicoGenomics Database]
Other databases
Probes
ProbePRDX1 Related clones (RZPD - Berlin)
PubMed
PubMed51 Pubmed reference(s) in Entrez

Bibliography

A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins.
Prospˆ©ri MT, Ferbus D, Karczinski I, Goubin G
The Journal of biological chemistry. 1993 ; 268 (15) : 11050-11056.
PMID 8496166
 
Organization and chromosomal assignment of two human PAG gene loci: PAGA encoding a functional gene and PAGB a processed pseudogene.
Prospˆ©ri MT, Apiou F, Dutrillaux B, Goubin G
Genomics. 1994 ; 19 (2) : 236-241.
PMID 8188254
 
Cloning and sequence analysis of candidate human natural killer-enhancing factor genes.
Shau H, Butterfield LH, Chiu R, Kim A
Immunogenetics. 1994 ; 40 (2) : 129-134.
PMID 8026862
 
Identification of natural killer enhancing factor as a major antioxidant in human red blood cells.
Shau H, Kim A
Biochemical and biophysical research communications. 1994 ; 199 (1) : 83-88.
PMID 8123050
 
Antioxidant function of recombinant human natural killer enhancing factor.
Sauri H, Butterfield L, Kim A, Shau H
Biochemical and biophysical research communications. 1995 ; 208 (3) : 964-969.
PMID 7702627
 
Recombinant natural killer enhancing factor augments natural killer cytotoxicity.
Sauri H, Ashjian PH, Kim AT, Shau H
Journal of leukocyte biology. 1996 ; 59 (6) : 925-931.
PMID 8691079
 
The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity.
Wen ST, Van Etten RA
Genes & development. 1997 ; 11 (19) : 2456-2467.
PMID 9334312
 
Characterization of a mammalian peroxiredoxin that contains one conserved cysteine.
Kang SW, Baines IC, Rhee SG
The Journal of biological chemistry. 1998 ; 273 (11) : 6303-6311.
PMID 9497358
 
The pag gene product, a physiological inhibitor of c-abl tyrosine kinase, is overexpressed in cells entering S phase and by contact with agents inducing oxidative stress.
Prospˆ©ri MT, Ferbus D, Rouillard D, Goubin G
FEBS letters. 1998 ; 423 (1) : 39-44.
PMID 9506838
 
Expression of the antioxidant gene NKEF in the central nervous system.
Sarafian TA, Huang C, Kim A, de Vellis J, Shau H
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid. 1998 ; 34 (1) : 39-51.
PMID 9778645
 
Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product.
Hirotsu S, Abe Y, Okada K, Nagahara N, Hori H, Nishino T, Hakoshima T
Proceedings of the National Academy of Sciences of the United States of America. 1999 ; 96 (22) : 12333-12338.
PMID 10535922
 
Differential expression of peroxiredoxin subtypes in human brain cell types.
Sarafian TA, Verity MA, Vinters HV, Shih CC, Shi L, Ji XD, Dong L, Shau H
Journal of neuroscience research. 1999 ; 56 (2) : 206-212.
PMID 10494109
 
Peroxiredoxin I expression in human thyroid tumors.
Yanagawa T, Ishikawa T, Ishii T, Tabuchi K, Iwasa S, Bannai S, Omura K, Suzuki H, Yoshida H
Cancer letters. 1999 ; 145 (1-2) : 127-132.
PMID 10530780
 
Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system.
Mizusawa H, Ishii T, Bannai S
Neuroscience letters. 2000 ; 283 (1) : 57-60.
PMID 10729633
 
Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Yanagawa T, Iwasa S, Ishii T, Tabuchi K, Yusa H, Onizawa K, Omura K, Harada H, Suzuki H, Yoshida H
Cancer letters. 2000 ; 156 (1) : 27-35.
PMID 10840156
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written10-2000Maité P Prosperi, Didier Ferbus, Gérard.Goubin
Laboratoire d'Oncogenese, UMR147 CNRS, Section de recherche, Institut Curie, Paris, France.
Updated12-2000Jean-Loup Huret

Citation

This paper should be referenced as such :
Prosperi MP, Ferbus D, Goubin G . PRDX1 (peroxiredoxin 1). Atlas Genet Cytogenet Oncol Haematol. October 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/PAGID266.html
Huret JL . PRDX1 (peroxiredoxin 1). Atlas Genet Cytogenet Oncol Haematol. December 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/PAGID266.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 6 17:58:09 2008


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