| Note |
Paired mesoderm homeobox protein 2, Paired related homeobox protein 2 |
| Description | 253 amino acids, 27 kDa, contains an homeobox DNA-binding domain and an OAR domain. |
| Expression | In embryon, higher levels of transcripts in heart, kidney, lung and skeletal muscle; lower levels in spleen and thymus ; barely detecteble levels in brain and liver.
In adult, higher levels in heart, lung, placenta and pancreas ; moderate expression in kidney and skeletal muscle. |
| Localisation | Nuclear |
| Function | Fetal skin development, cutaneous regeneration and possible role in cellular proliferation. Transcription factor activity. |
| Homology | Member of the paired family of homeobox proteins.
Murine Prrx2. |
| Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. |
| Stelnicki EJ, Arbeit J, Cass DL, Saner C, Harrison M, Largman C |
| The Journal of investigative dermatology. 1998 ; 111 (1) : 57-63. |
| PMID 9665387 |
| |
| NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15). |
| Nakamura T, Yamazaki Y, Hatano Y, Miura I |
| Blood. 1999 ; 94 (2) : 741-747. |
| PMID 10397741 |
| |
| Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome. |
| Norris RA, Scott KK, Moore CS, Stetten G, Brown CR, Jabs EW, Wulfsberg EA, Yu J, Kern MJ |
| Mammalian genome : official journal of the International Mammalian Genome Society. 2000 ; 11 (11) : 1000-1005. |
| PMID 11063257 |
| |
| NUP98 gene fusions in hematologic malignancies. |
| Lam DH, Aplan PD |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2001 ; 15 (11) : 1689-1695. |
| PMID 11681408 |
| |
| Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses. |
| White P, Thomas DW, Fong S, Stelnicki E, Meijlink F, Largman C, Stephens P |
| The Journal of investigative dermatology. 2003 ; 120 (1) : 135-144. |
| PMID 12535210 |
| |
| A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. |
| Gervais C, Mauvieux L, Perrusson N, Hˆ©lias C, Struski S, Leymarie V, Lioure B, Lessard M |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (1) : 145-148. |
| PMID 15496970 |
| |
