| Note | Nectin-4 belongs to the family of adhesion molecules: Nectins. Four members have been described ( Nectin-1, Nectin-2, Nectin-3 and Nectin-4). Nectins belong to the immunoglobulin superfamily and exhibit three Ig-like domain in their extracellular region. |
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| | Extracellular region of dimeric Nectin-4 is composed with three Ig domains of Ig V and IgC types. The last 4 aminoacids in the C-terminus region binds to the scaffold F-actin binding protein AF-6/afadin. Nectin-4 ectodomain is shedded from cell surface by the metalloprotease TACE/ ADAM-17. |
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| Description | Nectin-4 protein is 510 aminoacid long. Molecular weight is 66 kDa. |
| Expression | Nectin-4 expression in mainly expressed during development. In mice Nectin-4 transcript are detected at day 11 d.p.c. In human Nectin-4 is not expressed in adult tissues. |
| Localisation | Nectin-4 is expressed at epithelial adherens junctions. In tumors Nectin-4 expression can be observed in the cytoplasm. |
| Function | Nectin-4 binds Nectin-1 through IgV domain interaction. Nectin-1 is involved in development. Nectin-4 increases tumor cell migration. |
| Homology | With other members of the family. |
| Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. |
| Reymond N, Fabre S, Lecocq E, AdelaˆØde J, Dubreuil P, Lopez M |
| The Journal of biological chemistry. 2001 ; 276 (46) : 43205-43215. |
| PMID 11544254 |
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| Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C-D beta-strands of the nectin1 V domain. |
| Fabre S, Reymond N, Cocchi F, Menotti L, Dubreuil P, Campadelli-Fiume G, Lopez M |
| The Journal of biological chemistry. 2002 ; 277 (30) : 27006-27013. |
| PMID 12011057 |
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| Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17. |
| Fabre-Lafay S, Garrido-Urbani S, Reymond N, Gonˆßalves A, Dubreuil P, Lopez M |
| The Journal of biological chemistry. 2005 ; 280 (20) : 19543-19550. |
| PMID 15784625 |
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| Nectin-4 is a new histological and serological tumor associated marker for breast cancer. |
| Fabre-Lafay S, Monville F, Garrido-Urbani S, Berruyer-Pouyet C, Ginestier C, Reymond N, Finetti P, Sauvan R, Adˆ©laˆØde J, Geneix J, Lecocq E, Popovici C, Dubreuil P, Viens P, Gonˆßalves A, Charafe-Jauffret E, Jacquemier J, Birnbaum D, Lopez M |
| BMC cancer. 2007 ; 7 : page 73. |
| PMID 17474988 |
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