RANBP2 (RAN binding protein)

Identity

Other names	NUP358 (nucleoporin 358 kDa)
HGNC	RANBP2
Location	2q13
Location_base_pair	Starts at 108702369 and ends at 108768699 bp from pter (hg18-Mar_2006).

Protein

Description	3224 amino acids, 358 kDa; is composed, from N-term to C-term, of: a leucine -rich region with a leucine zipper, 4 RAN-binding domains, , 8 Zn fingers, and an internal repeat region
Function	nuclear export transporter; bind RAN-GTP and exportin-1

Implicated in

Entity	Inflammatory myofibroblastic tumors with t(2;2)(p23;q13)
Disease	rare soft tissue tumour found in children and young adults
Prognosis	good prognosis
Hybrid/Mutated Gene	5' RANBP2 - 3' ALK

External links

	Nomenclature
HGNC	RANBP2   9848
Entrez_Gene	RANBP2  5903  RAN binding protein 2
	Cards
Atlas	RANBP2ID483
GeneCards	RANBP2
Ensembl	RANBP2 [Search_View]   ENSG00000153201 [Gene_View]
Genatlas	RANBP2
GeneLynx	RANBP2
eGenome	RANBP2
euGene	5903
	Genomic and cartography
GoldenPath	RANBP2  -  2q13   chr2:108702369-108768699 +  2q13   [Description]    (hg18-Mar_2006)
Ensembl	RANBP2 - 2q13 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	RANBP2
	Gene and transcription
Genbank	AA971491 [ ENTREZ ]
Genbank	AB209483 [ ENTREZ ]
Genbank	AK025462 [ ENTREZ ]
Genbank	AK025711 [ ENTREZ ]
Genbank	AK026993 [ ENTREZ ]
RefSeq	NM_006267 [ SRS ]    NM_006267 [ ENTREZ ]
RefSeq	AC_000045 [ SRS ]    AC_000045 [ ENTREZ ]
RefSeq	AC_000134 [ SRS ]    AC_000134 [ ENTREZ ]
RefSeq	NC_000002 [ SRS ]    NC_000002 [ ENTREZ ]
RefSeq	NT_022171 [ SRS ]    NT_022171 [ ENTREZ ]
RefSeq	NW_001838822 [ SRS ]    NW_001838822 [ ENTREZ ]
RefSeq	NW_921374 [ SRS ]    NW_921374 [ ENTREZ ]
AceView	RANBP2 AceView - NCBI
Unigene	Hs.590897 [ SRS ]    Hs.590897 [ NCBI ]     HS590897 [ spliceNest ]
Fast-db	9351 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P49792 [ SRS]    P49792 [ EXPASY ]     P49792 [ INTERPRO ]     P49792 [ UNIPROT ]
Prosite	PS00170 CSA_PPIASE_1 [ SRS ]    PS00170 CSA_PPIASE_1 [ Expasy ]
Prosite	PS50072 CSA_PPIASE_2 [ SRS ]    PS50072 CSA_PPIASE_2 [ Expasy ]
Prosite	PS50196 RANBD1 [ SRS ]    PS50196 RANBD1 [ Expasy ]
Prosite	PS50005 TPR [ SRS ]    PS50005 TPR [ Expasy ]
Prosite	PS50293 TPR_REGION [ SRS ]    PS50293 TPR_REGION [ Expasy ]
Prosite	PS01358 ZF_RANBP2_1 [ SRS ]    PS01358 ZF_RANBP2_1 [ Expasy ]
Prosite	PS50199 ZF_RANBP2_2 [ SRS ]    PS50199 ZF_RANBP2_2 [ Expasy ]
Interpro	IPR011993 PH_type [ SRS ]    IPR011993 PH_type [ EBI ]
Interpro	IPR002130 PPIase_cyclophilin [ SRS ]    IPR002130 PPIase_cyclophilin [ EBI ]
Interpro	IPR000156 RanBP1 [ SRS ]    IPR000156 RanBP1 [ EBI ]
Interpro	IPR001440 TPR-1 [ SRS ]    IPR001440 TPR-1 [ EBI ]
Interpro	IPR011990 TPR-like_helical [ SRS ]    IPR011990 TPR-like_helical [ EBI ]
Interpro	IPR013026 TPR_region [ SRS ]    IPR013026 TPR_region [ EBI ]
Interpro	IPR001876 Znf_RanBP2 [ SRS ]    IPR001876 Znf_RanBP2 [ EBI ]
CluSTr	P49792
Pfam	PF00160 Pro_isomerase [ SRS ]    PF00160 Pro_isomerase [ Sanger ]    pfam00160 [ NCBI-CDD ]
Pfam	PF00638 Ran_BP1 [ SRS ]    PF00638 Ran_BP1 [ Sanger ]    pfam00638 [ NCBI-CDD ]
Pfam	PF00515 TPR_1 [ SRS ]    PF00515 TPR_1 [ Sanger ]    pfam00515 [ NCBI-CDD ]
Pfam	PF00641 zf-RanBP [ SRS ]    PF00641 zf-RanBP [ Sanger ]    pfam00641 [ NCBI-CDD ]
Smart	SM00160 RanBD [EMBL]
Smart	SM00547 ZnF_RBZ [EMBL]
Blocks	P49792
PDB	1RRP [ SRS ]    1RRP [ PdbSum ],   1RRP [ IMB ]   1RRP [ RSDB ]
PDB	1XKE [ SRS ]    1XKE [ PdbSum ],   1XKE [ IMB ]   1XKE [ RSDB ]
PDB	1Z5S [ SRS ]    1Z5S [ PdbSum ],   1Z5S [ IMB ]   1Z5S [ RSDB ]
HPRD	03111
	Protein Interaction databases
DIP	P49792
IntAct	P49792
	Polymorphism : SNP, mutations, diseases
OMIM	601181    [ map ]
GENECLINICS	601181
SNP	RANBP2 [dbSNP-NCBI]
SNP	NM_006267 [SNP-NCI]
SNP	RANBP2 [GeneSNPs - Utah]  RANBP2] [HGBASE - SRS]
HAPMAP	RANBP2 [HAPMAP]
COSMIC	RANBP2 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	RANBP2 [Translocation breakpoints In Cancer]
HGMD	RANBP2
	General knowledge
Family Browser	RANBP2 [UCSC Family Browser]
SOURCE	NM_006267
SMD	Hs.590897
SAGE	Hs.590897
GO	peptidyl-prolyl cis-trans isomerase activity [Amigo]  peptidyl-prolyl cis-trans isomerase activity
GO	protein binding [Amigo]  protein binding
GO	intracellular [Amigo]  intracellular
GO	nucleus [Amigo]  nucleus
GO	nuclear pore [Amigo]  nuclear pore
GO	cytosol [Amigo]  cytosol
GO	protein folding [Amigo]  protein folding
GO	protein import into nucleus [Amigo]  protein import into nucleus
GO	zinc ion binding [Amigo]  zinc ion binding
GO	Ran GTPase binding [Amigo]  Ran GTPase binding
GO	protein transport [Amigo]  protein transport
GO	isomerase activity [Amigo]  isomerase activity
GO	metal ion binding [Amigo]  metal ion binding
GO	intracellular transport [Amigo]  intracellular transport
GO	mRNA transport [Amigo]  mRNA transport
GO	intracellular protein transport across a membrane [Amigo]  intracellular protein transport across a membrane
BIOCARTA	Mechanism of Protein Import into the Nucleus    [Genes]
BIOCARTA	Cycling of Ran in nucleocytoplasmic transport    [Genes]
BIOCARTA	Sumoylation by RanBP2 Regulates Transcriptional Repression    [Genes]
PubGene	RANBP2
TreeFam	RANBP2
CTD	5903 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	RANBP2 Related clones (RZPD - Berlin)
	PubMed
PubMed	53 Pubmed reference(s) in Entrez

Bibliography

A giant nucleopore protein that binds Ran/TC4.

Yokoyama N, Hayashi N, Seki T, Pantˆ© N, Ohba T, Nishii K, Kuma K, Hayashida T, Miyata T, Aebi U

Nature. 1995 ; 376 (6536) : 184-188.

PMID 7603572

A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.

Mahajan R, Delphin C, Guan T, Gerace L, Melchior F

Cell. 1997 ; 88 (1) : 97-107.

PMID 9019411

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

Nothwang HG, Rensing C, Kˆºbler M, Denich D, Brandl B, Stubanus M, Haaf T, Kurnit D, Hildebrandt F

Genomics. 1998 ; 47 (3) : 383-392.

PMID 9480752

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.

Vetter IR, Nowak C, Nishimoto T, Kuhlmann J, Wittinghofer A

Nature. 1999 ; 398 (6722) : 39-46.

PMID 10078529

GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358.

Yaseen NR, Blobel G

The Journal of biological chemistry. 1999 ; 274 (37) : 26493-26502.

PMID 10473610

Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor.

Ma Z, Hill DA, Collins MH, Morris SW, Sumegi J, Zhou M, Zuppan C, Bridge JA

Genes, chromosomes & cancer. 2003 ; 37 (1) : 98-105.

PMID 12661011

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	08-2003	Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :

Huret JL, Senon S . RANBP2 (RAN binding protein). Atlas Genet Cytogenet Oncol Haematol. August 2003 . URL : http://AtlasGeneticsOncology.org/Genes/RANBP2ID483.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 12:56:04 2008