| Description | rap1gds, also refered as smgGDS - 61.1 kDa, 558 aa. Contains in major part an armadillo motif, which is composed of tandemly repeated sequences of 43 amino acid residues. |
| Expression | Ubiquitary, high level of expression in central nervous system. |
| Function | Acts as guanine nucleotide exchange factor (GEF). Activates GDP/GTP exchange reaction on numerous small proteins with GTPase activity (G proteins) containing a C-terminal polybasic region (PBR), including Ras and Rho family GTPases such as rap1a, rap1b, K-ras, rac1, rac2, rhoA, ralB. These proteins play a pivotal role in cell proliferation, differentiation and oncogenic transformation. |
| Homology | With other mammalian rap1gds1 proteins. |
| Inhibition of adenylate cyclase activity by galanin in rat insulinoma cells is mediated by the G-protein Gi3. |
| de Mazancourt P, Goldsmith PK, Weinstein LS |
| The Biochemical journal. 1994 ; 303 ( Pt 2) : 369-375. |
| PMID 7526840 |
| |
| The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia. |
| Hussey DJ, Nicola M, Moore S, Peters GB, Dobrovic A |
| Blood. 1999 ; 94 (6) : 2072-2079. |
| PMID 10477737 |
| |
| t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: characterization of a new subset of T acute lymphoblastic leukaemia. |
| Mecucci C, La Starza R, Negrini M, Sabbioni S, Crescenzi B, Leoni P, Di Raimondo F, Krampera M, Cimino G, Tafuri A, Cuneo A, Vitale A, FoˆÝ R |
| British journal of haematology. 2000 ; 109 (4) : 788-793. |
| PMID 10929031 |
| |
| SmgGDS displays differential binding and exchange activity towards different Ras isoforms. |
| Vikis HG, Stewart S, Guan KL |
| Oncogene. 2002 ; 21 (15) : 2425-2432. |
| PMID 11948427 |
| |