RAP2B

Identity

HGNC	RAP2B
Location	3q24
Location_base_pair	Starts at 154362719 and ends at 154368953 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

Description	The gene contains 1 coding exon only covering 644 bp

Protein

Description	Rap2 is a member of the Ras superfamily of monomeric GTPases, closely related to Ras. There are twoisoforms, Rap2A and Rap2B that share 90% identity and are encoded by two different genes. Rap2 proteinsshare 50% identity with Ras proteins, including the regions involved in GDP/GTP binding (hence Rap2A hasvery similar biochemical properties to Ras), C-terminal CAAX domain leading to prenylation (farnesylationfor Rap2A and geranylgeranylation in the case of Rap2B) and palmitoylation. The effector region of Rap2 isvery similar to that of Ras proteins, yet Ras and Rap2 do share seem to share effectors.
Expression	ubiquitous ; higher in brain and hemopoietic tissues (especially rich in platelets and meutrophils)
Localisation	plasma and/or intracellular membranes (endoplasmic reticulum)
Function	unknown
Homology	90% identical to Rap2A, 60% identical to Rap1, 50 % to Ras proteins

Mutations

Germinal

unknown

Implicated in

Entity	no implication in pathologies characterized so far

To be noted

see also RAP family

External links

	Nomenclature
HGNC	RAP2B   9862
Entrez_Gene	RAP2B  5912  RAP2B, member of RAS oncogene family
	Cards
Atlas	RAP2BID275
GeneCards	RAP2B
Ensembl	ENSG00000181467 [Gene_View]  RAP2B [Vega]
Genatlas	RAP2B
	Genomic and cartography
GoldenPath	RAP2B  -  3q24   chr3:154362719-154368953 +  3q25.2   [Description]    (hg18-Mar_2006)
Ensembl	RAP2B - 3q25.2 [CytoView]
NCBI	Mapview
OMIM	179541 Disease map [OMIM]
HomoloGene	RAP2B
	Gene and transcription
Genbank	AF493915 [ ENTREZ ]
Genbank	AL713766 [ ENTREZ ]
Genbank	BC012362 [ ENTREZ ]
Genbank	BF965860 [ ENTREZ ]
Genbank	DQ891702 [ ENTREZ ]
RefSeq	NM_002886 [ SRS ]    NM_002886 [ ENTREZ ]
RefSeq	AC_000046 [ SRS ]    AC_000046 [ ENTREZ ]
RefSeq	AC_000135 [ SRS ]    AC_000135 [ ENTREZ ]
RefSeq	NC_000003 [ SRS ]    NC_000003 [ ENTREZ ]
RefSeq	NT_005612 [ SRS ]    NT_005612 [ ENTREZ ]
RefSeq	NW_001838884 [ SRS ]    NW_001838884 [ ENTREZ ]
RefSeq	NW_921807 [ SRS ]    NW_921807 [ ENTREZ ]
CCDS	RAP2B CCDS - NCBI
AceView	RAP2B AceView - NCBI
Unigene	Hs.98643 [ SRS ]    Hs.98643 [ NCBI ]
Fast-db	14111 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P61225 [ SRS]    P61225 [ EXPASY ]     P61225 [ INTERPRO ]     P61225 [ UNIPROT ] P61225 [ VarSplice FASTA ]
Interpro	IPR003577 GTPase_Ras [ SRS ]    IPR003577 GTPase_Ras [ EBI ]
Interpro	IPR013753 Ras [ SRS ]    IPR013753 Ras [ EBI ]
Interpro	IPR001806 Ras_trnsfrmng [ SRS ]    IPR001806 Ras_trnsfrmng [ EBI ]
Interpro	IPR005225 Small_GTP_bd [ SRS ]    IPR005225 Small_GTP_bd [ EBI ]
CluSTr	P61225
Pfam	PF00071 Ras [ SRS ]    PF00071 Ras [ Sanger ]    pfam00071 [ NCBI-CDD ]
Smart	SM00173 RAS [EMBL]
Blocks	P61225
HPRD	01548
	Protein Interaction databases
DIP	P61225
IntAct	P61225
	Polymorphism : SNP, mutations, diseases
OMIM	179541    [ map ]
GENETests	179541
SNP	RAP2B [dbSNP-NCBI]
SNP	NM_002886 [SNP-NCI]
SNP	RAP2B [GeneSNPs - Utah]  RAP2B] [HGBASE - SRS]
HAPMAP	RAP2B [HAPMAP]
COSMIC	RAP2B [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	RAP2B
Genetic Association	RAP2B
CDC HuGE	RAP2B
	General knowledge
Family Browser	RAP2B [UCSC Family Browser]
SOURCE	NM_002886
SMD	Hs.98643
SAGE	Hs.98643
GO	nucleotide binding [Amigo]  nucleotide binding
GO	GTP binding [Amigo]  GTP binding
GO	intracellular [Amigo]  intracellular
GO	plasma membrane [Amigo]  plasma membrane
GO	signal transduction [Amigo]  signal transduction
GO	small GTPase mediated signal transduction [Amigo]  small GTPase mediated signal transduction
BIOCARTA	Phospholipase C-epsilon pathway    [Genes]
PubGene	RAP2B
TreeFam	RAP2B
CTD	5912 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	RAP2B Related clones (RZPD - Berlin)
	PubMed
PubMed	16 Pubmed reference(s) in Entrez

Bibliography

Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.

Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M

Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083.

PMID 10913189

Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.

Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M

Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083.

PMID 10913189

Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.

Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M

Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083.

PMID 10913189

Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.

Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M

Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083.

PMID 10913189

Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.

Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M

Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083.

PMID 10913189

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	05-2001	Jean de Gunzburg

Citation

This paper should be referenced as such :

Gunzburg J de . RAP2B. Atlas Genet Cytogenet Oncol Haematol. May 2001 . URL : http://AtlasGeneticsOncology.org/Genes/RAP2BID275.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Dec 6 17:58:54 2008