| Description | The human rel gene encodes a protein composed 619 amino acids with an approximately molecular weight of 68 - 70 kDa. The Rel protein is structurally similar with other Rel family members containing RHD, NLS and TA domain. However, analysis of X-ray crystal structure revealed that the Rel homodimer preferentially binds to the CD28RE with higher affinity as compared to other canonical kB sequences. |
| Expression | wide. |
| Localisation | cytosol, nuclei after activation. |
| Function | regulation of the genes involved in cell-to-cell interaction, intercellular communication, cell recruitment or transmigration, amplification or spreading of primary pathogenic signals, cell apoptosis, and initiation or acceleration of tumorigenesis. Interaction with: members of IkB family and Rel family; MKK4; c-Fos; c-Jun; UBE2; PPP4C. |
| Alterations at the rel locus in human lymphoma. |
| Lu D, Thompson JD, Gorski GK, Rice NR, Mayer MG, Yunis JJ |
| Oncogene. 1991 ; 6 (7) : 1235-1241. |
| PMID 1650444 |
| |
| Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing. |
| Deloukas P, van Loon AP |
| Human molecular genetics. 1993 ; 2 (11) : 1895-1900. |
| PMID 8281153 |
| |
| The NF-kappa B and I kappa B proteins: new discoveries and insights. |
| Baldwin AS Jr |
| Annual review of immunology. 1996 ; 14 : 649-683. |
| PMID 8717528 |
| |
| NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. |
| Ghosh S, May MJ, Kopp EB |
| Annual review of immunology. 1998 ; 16 : 225-260. |
| PMID 9597130 |
| |
| Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. |
| Zhong H, Voll RE, Ghosh S |
| Molecular cell. 1998 ; 1 (5) : 661-671. |
| PMID 9660950 |
| |
| Aberrant rel/nfkb genes and activity in human cancer. |
| Rayet B, Gˆ©linas C |
| Oncogene. 1999 ; 18 (49) : 6938-6947. |
| PMID 10602468 |
| |