SYNPO2

Identity

Other names	Myopodin
	synaptopodin 2
Hugo	SYNPO2
Location	4q27

Note	Myopodin probably represents an alternative splicing variant of synaptopodin 2. The predicted synaptopodin 2 contains 1021 amino acid and myopodin 698. The extra 323 amino acid in synaptopodin 2 is located at the N-terminus.

DNA/RNA

	Genome structure of myopodin and synaptopodin 2. Green represents exons of myopodin, and orange synaptopodin 2. Introns are indicated with lines.
Description	The genome sequence of myopodin contains 6.8 Kb, while synaptopodin 2 38 kb.
Transcription	A typical messenger RNA of myopodin is 4.2-4.4 kb, and synaptopodin 2 6.7 kb.
Pseudogene	Unknown

Protein

	Protein structure of myopodin and synaptopodin 2. Orange represents sequence unique to synaptopodin 2, Green myopodin. Black stripe represents sequence homologous to synaptopodin 1.

Description	A nuclear localization signal is identified in N-terminus region of myopodin. Myopodin also contains six stretches of homologous sequences with synaptopodin 1.
Expression	Skeletal muscle, prostate, large and small intestine.
Localisation	Nucleus, cytoplasm.
Function	Actin bundling.
Homology	Synaptopodin

Mutations

Germinal	Not known
Somatic	Deletion

Implicated in

Disease	Prostate cancer and urothelial cell carcinoma.
Prognosis	Deletion preferentially occurs in aggressive type of prostate cancer. Loss of expression in nucleus in urothelial cell carcinoma is predictive of poor clinical outcome.
Cytogenetics	Not known

External links

	Nomenclature
Hugo	SYNPO2
GDB	SYNPO2
Entrez_Gene	SYNPO2  171024  synaptopodin 2
	Cards
Atlas	SYNPO2ID488
GeneCards	SYNPO2
Ensembl	SYNPO2 [Search_View]   ENSG00000172403 [Gene_View]
Genatlas	SYNPO2
GeneLynx	SYNPO2
eGenome	SYNPO2
euGene	171024
	Genomic and cartography
GoldenPath	SYNPO2  -  4q27   chr4:120029444-120201841 +  4q26    (hg18-Mar_2006)
Ensembl	SYNPO2 - 4q26 [CytoView]
NCBI	Mapview
HomoloGene	SYNPO2
	Gene and transcription
Genbank	AF177291 [ ENTREZ ]
Genbank	AJ010482 [ ENTREZ ]
Genbank	AK000774 [ ENTREZ ]
Genbank	AL832031 [ ENTREZ ]
Genbank	AL832363 [ ENTREZ ]
RefSeq	NM_133477 [ SRS ]    NM_133477 [ ENTREZ ]
RefSeq	AC_000047 [ SRS ]    AC_000047 [ ENTREZ ]
RefSeq	NC_000004 [ SRS ]    NC_000004 [ ENTREZ ]
RefSeq	NT_016354 [ SRS ]    NT_016354 [ ENTREZ ]
RefSeq	NW_922195 [ SRS ]    NW_922195 [ ENTREZ ]
AceView	SYNPO2 AceView - NCBI
Unigene	Hs.655519 [ SRS ]    Hs.655519 [ NCBI ]     HS655519 [ spliceNest ]
Fast-db	8895 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q9UMS6 [ SRS]    Q9UMS6 [ EXPASY ]     Q9UMS6 [ INTERPRO ]
Prosite	PS50106 PDZ [ SRS ]    PS50106 PDZ [ Expasy ]
Interpro	IPR001478 PDZ [ SRS ]    IPR001478 PDZ [ EBI ]
CluSTr	Q9UMS6
Pfam	PF00595 PDZ [ SRS ]    PF00595 PDZ [ Sanger ]    pfam00595 [ NCBI-CDD ]
Smart	SM00228 PDZ [EMBL]
Blocks	Q9UMS6
HPRD	15456
	Protein Interaction databases
DIP	Q9UMS6
IntAct	Q9UMS6
	Polymorphism : SNP, mutations, diseases
SNP	SYNPO2 [dbSNP-NCBI]
SNP	NM_133477 [SNP-NCI]
SNP	SYNPO2 [GeneSNPs - Utah]  SYNPO2] [HGBASE - SRS]
HAPMAP	SYNPO2 [HAPMAP]
HGMD	SYNPO2
	General knowledge
Family Browser	SYNPO2 [UCSC Family Browser]
SOURCE	NM_133477
SMD	Hs.655519
SAGE	Hs.655519
GO	actin binding [Amigo]  actin binding
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
PubGene	SYNPO2
TreeFam	SYNPO2
	Other databases
	Probes
Probe	SYNPO2 Related clones (RZPD - Berlin)
	PubMed
PubMed	10 Pubmed reference(s) in LocusLink

Bibliography

Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers.

Lin F, Yu YP, Woods J, Cieply K, Gooding B, Finkelstein P, Dhir R, Krill D, Becich MJ, Michalopoulos G, Finkelstein S, Luo JH

The American journal of pathology. 2001 ; 159 (5) : 1603-1612.

PMID 11696420

Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein.

Weins A, Schwarz K, Faul C, Barisoni L, Linke WA, Mundel P

The Journal of cell biology. 2001 ; 155 (3) : 393-404.

PMID 11673475

Tumor suppressor role for myopodin in bladder cancer: loss of nuclear expression of myopodin is cell-cycle dependent and predicts clinical outcome.

Sanchez-Carbayo M, Schwarz K, Charytonowicz E, Cordon-Cardo C, Mundel P

Oncogene. 2003 ; 22 (34) : 5298-5305.

PMID 12917631

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	12-2003	Jian-Hua Luo

Citation

This paper should be referenced as such :

Luo JH . SYNPO2. Atlas Genet Cytogenet Oncol Haematol. December 2003 . URL : http://AtlasGeneticsOncology.org/Genes/SYNPO2ID488.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon May 12 18:09:27 2008