Atlas of Genetics and Cytogenetics in Oncology and Haematology
TAF15 (TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa)
| Identity |
| Other names | TAFIIN |
| TAF2N (TATA box binding protein (TBP)-associated factor, RNA polymerase II, N) | |
| RBP56 (RNA binding protein 56) | |
| TAFII68 | |
| HGNC | TAF15 |
| Location | 17q11.1-q11.2 |
| DNA/RNA |
| Description | spans 37kb; 16 exons |
| Transcription | 2.2 bp mRNA; alternative splicing: two isoforms of cDNAs consisting of 2144 and 2153 bp; coding sequence 1778 bp |
| Protein |
| Description | 589 and 592 amino acid, 62 kDa ; comprises a N-term ser, tyr, gln, gly -rich region, followed by a an RNA binding domain and a Cys2/Cys2 finger motif, and repeats in C-term |
| Expression | wide; in the fetus and in the adult |
| Localisation | nuclear |
| Function | single strand DNA/RNA binding protein; part of theTFIID and RNA polymerase II complex of proteins which assemble on the promoter to form a pre-initiation complex (PIC); TFIID is composed of a TATA-box-binding protein (TBP) and a number of TBP-associated factors (TAFIIS); contribute to the activation of transcription |
| Homology | with EWSR1 ID: 85 and |
| Mutations |
| Somatic | overexpression of TAF2N- FLI-1 chimeras in NIH3T3 cells leads to oncogenic transformation |
| Implicated in |
| Entity | extraskeletal myxoid chondrosarcomas with t(9;17)(q22;q11) --> 5 prime TAF2N/ 3 prime TEC |
| Disease | a rare tumour: 2.3% of soft tissue sarcomas often localized in deep soft tissues of the lower extremities |
| Breakpoints |
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| External links |
| Bibliography |
| Yeast TAFIIS in a multisubunit complex required for activated transcription. |
| Reese JC, Apone L, Walker SS, Griffin LA, Green MR |
| Nature. 1994 ; 371 (6497) : 523-527. |
| PMID 7935765 |
| Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins. |
| Morohoshi F, Arai K, Takahashi EI, Tanigami A, Ohki M |
| Genomics. 1996 ; 38 (1) : 51-57. |
| PMID 8954779 |
| Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes. |
| Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, Munakata N, Ohki M |
| Gene. 1998 ; 221 (2) : 191-198. |
| PMID 9795213 |
| Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma. |
| Sjgren H, Meis-Kindblom J, Kindblom LG, Aman P, Stenman G |
| Cancer research. 1999 ; 59 (20) : 5064-5067. |
| PMID 10537274 |
| Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11). |
| Panagopoulos I, Mencinger M, Dietrich CU, Bjerkehagen B, Saeter G, Mertens F, Mandahl N, Heim S |
| Oncogene. 1999 ; 18 (52) : 7594-7598. |
| PMID 10602519 |
| The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties. |
| Bertolotti A, Bell B, Tora L |
| Oncogene. 1999 ; 18 (56) : 8000-8010. |
| PMID 10637511 |
| TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes. |
| Green MR |
| Trends in biochemical sciences. 2000 ; 25 (2) : 59-63. |
| PMID 10664584 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 09-2000 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . TAF15 (TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa). Atlas Genet Cytogenet Oncol Haematol. September 2000 . URL : http://AtlasGeneticsOncology.org/Genes/TAF2NID256.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Aug 11 21:17:49 2008 |
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