TAL1 (T-cell acute leukemia 1)

Identity

Other names	SCL (stem cell leukaemia), TCL5 (T cell leukaemia 5)
Hugo	TAL1
Location	1p32

DNA/RNA

	DNA diagram
Description	8 exons; 16 kb; SIL (a different gene) sits 90 kb further in 5'
Transcription	(complex) alternate splicing of: 1A with 2A, or 3 vs 1B, 2B,3 ...or directly 4, 5, 6

Protein

Description	331 amino acids for the major form of 48 KDa; a truncated form of 26 KDa only in some T-ALL; domains: prolin rich in N-trem; poly Gly; basic Helix-Loop-Helix from the exon 6.
Expression	in hematopoietic stem cells, erythroid and megakaryocytic lineages of the adult and in the embryonic brain; indispensable for the genesis of the hematopoietic system.
Function	transcription factor; exhibits sequence-specific DNA binding activity when in dimers with another bHLH protein such as E2A (DNA specific sequences are: CANNTG, especially: CAGATG); direct interactions of the bHLH with the LIM domain of RBTN2 or RBTN1.
Homology	TAL2 in 9q32; LYL1 in 19p13; more distantly: MYC and other members of the MYC family of Helix-Loop-Helix transcription factors.

Implicated in

Entity	t(1;7)(p32;q34) or t(1;14)(p32;q11)/T-ALL --> TAL1-TCRB or TAL1-TCRD
Disease	T-cell ALL
Prognosis	is not too poor, compared to other T-ALL
Entity	T-ALL with normal karyotype, but with submicroscopic deletions of part of TAL1 in the 5' region --> SIL-TAL1.
Disease	found in 10 to 30 % of T-ALL with a normal karyotype
Hybrid/Mutated Gene	deletions which place SIL (SCL interrupting sequence) in close 5' of TAL1; hybrid gene with exon 1 from SIL.
Abnormal Protein	TAL1 is under the promoter sequences controle of SIL, a gene active during T cell development.
Entity	t(1;3)(p32;p21)/T-ALL --> TAL1-TCTA
Disease	T-cell ALL

Breakpoints

Note	mainly in 5' in a 1 kb region; but also dispersed in rare cases

External links

	Nomenclature
Hugo	TAL1
GDB	TAL1
Entrez_Gene	TAL1  6886  T-cell acute lymphocytic leukemia 1
	Cards
Atlas	TAL1
GeneCards	TAL1
Ensembl	TAL1 [Search_View]   ENSG00000162367 [Gene_View]
Genatlas	TAL1
GeneLynx	TAL1
eGenome	TAL1
euGene	6886
	Genomic and cartography
GoldenPath	TAL1  -  1p32   chr1:47454551-47468030 -  1p32   [Description]    (hg18-Mar_2006)
Ensembl	TAL1 - 1p32 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TAL1
	Gene and transcription
Genbank	CR624822 [ ENTREZ ]
Genbank	M29038 [ ENTREZ ]
Genbank	M61108 [ ENTREZ ]
Genbank	S53245 [ ENTREZ ]
Genbank	X51990 [ ENTREZ ]
RefSeq	NM_003189 [ SRS ]    NM_003189 [ ENTREZ ]
RefSeq	AC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeq	NC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeq	NT_032977 [ SRS ]    NT_032977 [ ENTREZ ]
RefSeq	NW_921351 [ SRS ]    NW_921351 [ ENTREZ ]
AceView	TAL1 AceView - NCBI
Unigene	Hs.525198 [ SRS ]    Hs.525198 [ NCBI ]     HS525198 [ spliceNest ]
Fast-db	15891 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P17542 [ SRS]    P17542 [ EXPASY ]     P17542 [ INTERPRO ]
Prosite	PS50888 HLH [ SRS ]    PS50888 HLH [ Expasy ]
Interpro	IPR001092 HLH_basic [ SRS ]    IPR001092 HLH_basic [ EBI ]
Interpro	IPR011598 HLH_DNA_bd [ SRS ]    IPR011598 HLH_DNA_bd [ EBI ]
CluSTr	P17542
Pfam	PF00010 HLH [ SRS ]    PF00010 HLH [ Sanger ]    pfam00010 [ NCBI-CDD ]
Smart	SM00353 HLH [EMBL]
Blocks	P17542
HPRD	01753
	Protein Interaction databases
DIP	P17542
IntAct	P17542
	Polymorphism : SNP, mutations, diseases
OMIM	187040    [ map ]
GENECLINICS	187040
SNP	TAL1 [dbSNP-NCBI]
SNP	NM_003189 [SNP-NCI]
SNP	TAL1 [GeneSNPs - Utah]  TAL1] [HGBASE - SRS]
HAPMAP	TAL1 [HAPMAP]
COSMIC	TAL1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TAL1
	General knowledge
Family Browser	TAL1 [UCSC Family Browser]
SOURCE	NM_003189
SMD	Hs.525198
SAGE	Hs.525198
GO	DNA binding [Amigo]  DNA binding
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	nucleus [Amigo]  nucleus
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	cell proliferation [Amigo]  cell proliferation
GO	hemopoiesis [Amigo]  hemopoiesis
GO	erythrocyte differentiation [Amigo]  erythrocyte differentiation
GO	transcription regulator activity [Amigo]  transcription regulator activity
GO	protein complex [Amigo]  protein complex
GO	cell fate commitment [Amigo]  cell fate commitment
GO	regulation of transcription [Amigo]  regulation of transcription
PubGene	TAL1
TreeFam	TAL1
CTD	6886 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TAL1 Related clones (RZPD - Berlin)
	PubMed
PubMed	52 Pubmed reference(s) in LocusLink

Bibliography

Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL.

Ono Y, Fukuhara N, Yoshie O

The Journal of biological chemistry. 1997 ; 272 (7) : 4576-4581.

PMID 9020185

The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.

Hofmann TJ, Cole MD

Oncogene. 1996 ; 13 (3) : 617-624.

PMID 8760303

The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.

Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH

Cell. 1996 ; 86 (1) : 47-57.

PMID 8689686

Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1.

Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH

Proceedings of the National Academy of Sciences of the United States of America. 1995 ; 92 (21) : 9585-9589.

PMID 7568177

Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.

Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R

The EMBO journal. 1994 ; 13 (20) : 4831-4839.

PMID 7957052

Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study.

Bash RO, Crist WM, Shuster JJ, Link MP, Amylon M, Pullen J, Carroll AJ, Buchanan GR, Smith RG, Baer R

Blood. 1993 ; 81 (8) : 2110-2117.

PMID 8471769

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	08-1997	Jean-Loup Huret and Marie-Claude Labastie
		Institut d'Embryologie Cellulaire et Moléculaire, CNRS FRE 216O, 94736, Nogent-sur-Marne Cedex, France

Citation

This paper should be referenced as such :

Huret JL and Labastie MC . TAL1 (T-cell acute leukemia 1). Atlas Genet Cytogenet Oncol Haematol. August 1997 . URL : http://AtlasGeneticsOncology.org/Genes/TAL1.html

Huret JL and Labastie MC . TAL1 (T-cell acute leukemia 1). Atlas Genet Cytogenet Oncol Haematol. . URL : http://AtlasGeneticsOncology.org/Genes/TAL1.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Jul 2 08:27:25 2008