TRB (T cell Receptor Beta)

Identity

Hugo	TRB@
Location	7q35
	for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ® ) © Copyright 1995-2003 IMGT, IMGT is a CNRS trademark

Note	The human TRB locus is located on chromosome 7 on the long arm, at band 7q35. The orientation of the locus has been determined by the analysis of translocations, involving the TRB locus, in leukemia and lymphoma

DNA/RNA

	TRB V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene. D-GENE: Blue: Functional. J-GENE: Grey: Functional . C-GENE: Blue: Functional. GENES NOT RELATED: Purple: Functional; Purple open box: Pseudogene. for complete Figure, see: locus TRB, IGMT (The international ImMunoGeneTics information systemŽ) © Copyright 1995-2003 IMGT, IMGT is a CNRS trademark
Description	The human TRB locus at 7q35 spans 620 kb. It consists of 64-67 TRBV genes belonging to 32 subgroups. Except for TRBV30, localized downstream of the TRBC2 gene, in inverted orientation of transcription, all the other TRBV genes are located upstream of a duplicated D-J-C-cluster, which comprises, for the first part one TRBD, six TRBJ, and the TRBC1 gene, and for the second part, one TRBD, eight TRBJ, and the TRBC2 gene. The most 5' TRBV genes occupy the most centromeric position, whereas the TRBV30 gene, 3' of the locus, is the most telomeric gene in the TRB locus. The potentiel repertoire consists of 39-46 functional TRBV genes belonging to 21-23 subgroups, the two TRBD, thirteen TRBJ (6 from the first cluster and 7 from the second cluster), and the two TRBC genes. Six TRBV orphons have been localized on chromosome 9 at 9p21. Enhancer sequences have been characterized 5.5kb 3' from TRBC2. List of the human TRB genes

Protein

Description

Proteins encoded by the TRB locus are the T cell receptor beta chains. They result from the recombination (or rearrangement), at the DNA level, of three genes: TRBV, TRBD and TRBJ, with deletion of the intermediary DNA to create a rearranged TRBV-D-J gene. The rearranged TRBV-D-J gene is transcribed with one of the two TRBC genes and translated into a T cell receptor beta chain. Translation of the variable germline genes involved in the TRBV-D-J rearrangements are available at IMGT Repertoire Protein displays. TRB V-D-J rearrangements can be analysed using the IMGT/V-QUEST tool.

Mutations

Note	Mutations which correspond to allelic polymorphisms of the functional germline TRBV, TRBD, TRBJ and TRBC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

Implicated in

Entity	Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRBV, TRBD or TRBJ recombination signals or isolated heptamer are frequently observed at the breakpoints
Entity	t(1;7)(p34;q35); involve LCK in 1p34
Disease	T-cell acute lymphocytic leukemia (ALL)
Entity	t(1;7)(p32;q35); involve TAL1 in 1p32
Disease	T-cell acute lymphocytic leukemia (ALL)
Prognosis	median survival > 5 yrs in children
Entity	t(7;9)(q35;q32); involve TAL2 in 9q32
Disease	T-cell acute lymphocytic leukemia (ALL)
Entity	t(7;9)(q35;q34); involve TAN1 in 9q34
Disease	T-cell acute lymphocytic leukemia (ALL)
Entity	t(7;10)(q35;q24); involve HOX11 in 10q24
Disease	T- cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL)
Prognosis	not unfavourable
Entity	t(7;11)(q35;p13); involve RBTN2 in 11p13
Disease	T-cell acute lymphocytic leukemia (ALL)
Entity	t(7;14)(q35;q32); involve TCL1 in 14q32
Disease	T-cell lymphoproliferations
Entity	t(7;19)(q35;p13); involve LYL1 in 19p13
Disease	T-cell acute lymphoblastic leukemia (ALL)

Breakpoints

External links

	Nomenclature
Hugo	TRB@
GDB	TRB@
Entrez_Gene	TRB@  6957  T cell receptor beta locus
	Cards
Atlas	TCRBID24
GeneCards	TRB@
Ensembl	TRB@ [Search_View]   ENSG00000124678 [Gene_View]
Genatlas	TRB@
GeneLynx	TRB@
eGenome	TRB@
euGene	6957
	Genomic and cartography
GoldenPath	TRB@  -  7q35   chr7:141612136-142293599 7q34  hg18-Mar_2006   [Description]    ()
Ensembl	TRB@ - hg18-Mar_2006 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TRB@
	Gene and transcription
Genbank	- [ ENTREZ ]
RefSeq	AC_000068 [ SRS ]    AC_000068 [ ENTREZ ]
RefSeq	NC_000007 [ SRS ]    NC_000007 [ ENTREZ ]
RefSeq	NG_001333 [ SRS ]    NG_001333 [ ENTREZ ]
RefSeq	NT_007914 [ SRS ]    NT_007914 [ ENTREZ ]
RefSeq	NT_079596 [ SRS ]    NT_079596 [ ENTREZ ]
AceView	TRB@ AceView - NCBI
	Protein : pattern, domain, 3D structure
	Protein Interaction databases
	Polymorphism : SNP, mutations, diseases
OMIM	186930    [ map ]
GENECLINICS	186930
SNP	TRB@ [dbSNP-NCBI]
SNP	TRB@ [GeneSNPs - Utah]  TRB@] [HGBASE - SRS]
HAPMAP	TRB@ [HAPMAP]
HGMD	TRB@
	General knowledge
Family Browser	TRB@ [UCSC Family Browser]
GO	receptor activity [Amigo]  receptor activity
GO	plasma membrane [Amigo]  plasma membrane
GO	immune response [Amigo]  immune response
GO	MHC protein binding [Amigo]  MHC protein binding
GO	peptide antigen binding [Amigo]  peptide antigen binding
PubGene	TRB@
TreeFam	TRB@
CTD	6957 [Comparative ToxicoGenomics Database]
	Other databases
Other database	TRB@ - IMGT
	Probes
Probe	TRB@ Related clones (RZPD - Berlin)
	PubMed
PubMed	34 Pubmed reference(s) in LocusLink

Bibliography

Nomenclature of the human T cell Receptor genes (Review)

Lefranc MP

Current Protocols in Immunology. 2000.

The T cell Receptor FactsBook (Review)

Lefranc MP and Lefranc G

Academic Press, London, UK (. 1939.

Locus Map and Genomic repertoire of the Human Immunoglobulin Genes (Review)

Lefranc MP

The immunologist,. 2000.

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	07-2000	Marie-Paule Lefranc

Citation

This paper should be referenced as such :

Lefranc MP . TRB (T cell Receptor Beta). Atlas Genet Cytogenet Oncol Haematol. July 2000 . URL : http://AtlasGeneticsOncology.org/Genes/TCRBID24.html

Lefranc MP . TRB (T cell Receptor Beta). Atlas Genet Cytogenet Oncol Haematol. . URL : http://AtlasGeneticsOncology.org/Genes/TCRBID24.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Jul 2 08:27:30 2008