TCTA (T-cell leukemia translocation-associated gene)

Identity

HGNC	TCTA
Location	3p21

DNA/RNA

	DNA diagram
Transcription	2.1 kb mRNA

Protein

Description	103 amino acids; 11 kDa; rich in hydrophobic amino acids (residues 41-61)
Expression	wide, especially in kidneys
Localisation	may be a membrane associated protein, as there is a hydrophobic domain
Function	unknown
Homology	none is known

Implicated in

Entity	t(1;3)(p32;p21)/T-cell ALL --> TAL1 - TCTA
Disease	T-cell ALL
Hybrid/Mutated Gene	head to head orientation of TAL1 and TCTA
Abnormal Protein	no fusion protein, but possibly promoter exchange and gene disregulation

To be noted

on day 04 Feb 1998, nothing new has appeared since the above coted paper

External links

	Nomenclature
HGNC	TCTA   11692
Entrez_Gene	TCTA  6988  T-cell leukemia translocation altered gene
	Cards
Atlas	TCTA
GeneCards	TCTA
Ensembl	TCTA [Search_View]   ENSG00000145022 [Gene_View]
Genatlas	TCTA
GeneLynx	TCTA
eGenome	TCTA
euGene	6988
	Genomic and cartography
GoldenPath	TCTA  -  3p21   chr3:49424643-49428913 +  3p21   [Description]    (hg18-Mar_2006)
Ensembl	TCTA - 3p21 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TCTA
	Gene and transcription
Genbank	AA181568 [ ENTREZ ]
Genbank	AK000824 [ ENTREZ ]
Genbank	AK311839 [ ENTREZ ]
Genbank	BC005157 [ ENTREZ ]
Genbank	CB054963 [ ENTREZ ]
RefSeq	NM_022171 [ SRS ]    NM_022171 [ ENTREZ ]
RefSeq	AC_000046 [ SRS ]    AC_000046 [ ENTREZ ]
RefSeq	AC_000135 [ SRS ]    AC_000135 [ ENTREZ ]
RefSeq	NC_000003 [ SRS ]    NC_000003 [ ENTREZ ]
RefSeq	NT_022517 [ SRS ]    NT_022517 [ ENTREZ ]
RefSeq	NW_001838877 [ SRS ]    NW_001838877 [ ENTREZ ]
RefSeq	NW_921651 [ SRS ]    NW_921651 [ ENTREZ ]
AceView	TCTA AceView - NCBI
Unigene	Hs.517962 [ SRS ]    Hs.517962 [ NCBI ]     HS517962 [ spliceNest ]
Fast-db	6638 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P57738 [ SRS]    P57738 [ EXPASY ]     P57738 [ INTERPRO ]     P57738 [ UNIPROT ]
Interpro	IPR016560 T-cell_leukemia_transloc-assoc [ SRS ]    IPR016560 T-cell_leukemia_transloc-assoc [ EBI ]
CluSTr	P57738
Blocks	P57738
HPRD	15977
	Protein Interaction databases
DIP	P57738
IntAct	P57738
	Polymorphism : SNP, mutations, diseases
OMIM	600690    [ map ]
GENECLINICS	600690
SNP	TCTA [dbSNP-NCBI]
SNP	NM_022171 [SNP-NCI]
SNP	TCTA [GeneSNPs - Utah]  TCTA] [HGBASE - SRS]
HAPMAP	TCTA [HAPMAP]
HGMD	TCTA
	General knowledge
Family Browser	TCTA [UCSC Family Browser]
SOURCE	NM_022171
SMD	Hs.517962
SAGE	Hs.517962
PubGene	TCTA
TreeFam	TCTA
CTD	6988 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TCTA Related clones (RZPD - Berlin)
	PubMed
PubMed	7 Pubmed reference(s) in LocusLink

Bibliography

Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation.

Aplan PD, Johnson BE, Russell E, Chervinsky DS, Kirsch IR

Cancer research. 1995 ; 55 (9) : 1917-1921.

PMID 7728759

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	01-1998	Jean-Loup Huret
Updated	03-1998	Jean-Loup Huret

Citation

This paper should be referenced as such :

- . TCTA (T-cell leukemia translocation-associated gene). Atlas Genet Cytogenet Oncol Haematol. January 1998 . URL : http://AtlasGeneticsOncology.org/Genes/TCTA.html

Huret JL . TCTA (T-cell leukemia translocation-associated gene). Atlas Genet Cytogenet Oncol Haematol. March 1998 . URL : http://AtlasGeneticsOncology.org/Genes/TCTA.html

Huret JL . TCTA (T-cell leukemia translocation-associated gene). Atlas Genet Cytogenet Oncol Haematol. . URL : http://AtlasGeneticsOncology.org/Genes/TCTA.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:17:56 2008