TPM4 (tropomyosin )

Identity

HGNC	TPM4
Location	19p13.1

DNA/RNA

Transcription

alternate transcripts

Protein

Description	248 amino acids, 29 kDa. Coiled-coil structure
Function	Tropomyosins are actin-binding proteins; component of cytoskeletal microfilaments; tropomyosins mediate the effect of Ca2+ on the myosin-actin interaction In skeletal muscles, but their function in smooth muscles and other tissues is yet unknown
Homology	Other tropomyosins: TPM1 (alpha) located in 15q22, TPM2 (beta), located in 9q13, and TPM3 located in 1q25

Implicated in

Entity	Inflammatory myofibroblastic tumors with t(2;19)(p23;p13.1)
Disease	rare soft tissue tumour found in children and young adults
Prognosis	good prognosis
Hybrid/Mutated Gene	5' CLTC - 3' ALK
Abnormal Protein	221 N-term amino acids from TPM4 fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain); homodimerization of the fusion protein.
Oncogenesis	TPM4-ALK is contitutively activated

External links

	Nomenclature
HGNC	TPM4   12013
Entrez_Gene	TPM4  7171  tropomyosin 4
	Cards
Atlas	TPM4ID359
GeneCards	TPM4
Ensembl	TPM4 [Search_View]   ENSG00000167460 [Gene_View]
Genatlas	TPM4
GeneLynx	TPM4
eGenome	TPM4
euGene	7171
	Genomic and cartography
GoldenPath	TPM4  -  19p13.1   chr19:16048325-16074408 +  19p13.1   [Description]    (hg18-Mar_2006)
Ensembl	TPM4 - 19p13.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TPM4
	Gene and transcription
Genbank	AF186109 [ ENTREZ ]
Genbank	AK023385 [ ENTREZ ]
Genbank	AK307538 [ ENTREZ ]
Genbank	AK315076 [ ENTREZ ]
Genbank	BC002827 [ ENTREZ ]
RefSeq	NM_003290 [ SRS ]    NM_003290 [ ENTREZ ]
RefSeq	AC_000062 [ SRS ]    AC_000062 [ ENTREZ ]
RefSeq	AC_000151 [ SRS ]    AC_000151 [ ENTREZ ]
RefSeq	NC_000019 [ SRS ]    NC_000019 [ ENTREZ ]
RefSeq	NT_011295 [ SRS ]    NT_011295 [ ENTREZ ]
RefSeq	NW_001838484 [ SRS ]    NW_001838484 [ ENTREZ ]
RefSeq	NW_927195 [ SRS ]    NW_927195 [ ENTREZ ]
AceView	TPM4 AceView - NCBI
Unigene	Hs.631618 [ SRS ]    Hs.631618 [ NCBI ]     HS631618 [ spliceNest ]
Fast-db	8374 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P67936 [ SRS]    P67936 [ EXPASY ]     P67936 [ INTERPRO ]     P67936 [ UNIPROT ]
Prosite	PS00326 TROPOMYOSIN [ SRS ]    PS00326 TROPOMYOSIN [ Expasy ]
Interpro	IPR000533 Tropomyosin [ SRS ]    IPR000533 Tropomyosin [ EBI ]
CluSTr	P67936
Pfam	PF00261 Tropomyosin [ SRS ]    PF00261 Tropomyosin [ Sanger ]    pfam00261 [ NCBI-CDD ]
Blocks	P67936
HPRD	11734
	Protein Interaction databases
DIP	P67936
IntAct	P67936
	Polymorphism : SNP, mutations, diseases
OMIM	600317    [ map ]
GENECLINICS	600317
SNP	TPM4 [dbSNP-NCBI]
SNP	NM_003290 [SNP-NCI]
SNP	TPM4 [GeneSNPs - Utah]  TPM4] [HGBASE - SRS]
HAPMAP	TPM4 [HAPMAP]
COSMIC	TPM4 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	TPM4 [Translocation breakpoints In Cancer]
HGMD	TPM4
	General knowledge
Family Browser	TPM4 [UCSC Family Browser]
SOURCE	NM_003290
SMD	Hs.631618
SAGE	Hs.631618
GO	podosome [Amigo]  podosome
GO	actin binding [Amigo]  actin binding
GO	cytoplasm [Amigo]  cytoplasm
GO	muscle thin filament tropomyosin [Amigo]  muscle thin filament tropomyosin
GO	cell motility [Amigo]  cell motility
GO	structural constituent of muscle [Amigo]  structural constituent of muscle
GO	cortical cytoskeleton [Amigo]  cortical cytoskeleton
GO	filamentous actin [Amigo]  filamentous actin
PubGene	TPM4
TreeFam	TPM4
CTD	7171 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TPM4 Related clones (RZPD - Berlin)
	PubMed
PubMed	15 Pubmed reference(s) in LocusLink

Bibliography

Deciphering the design of the tropomyosin molecule.

Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C

Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (15) : 8496-8501.

PMID 11438684

Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors.

Griffin CA, Hawkins AL, Dvorak C, Henkle C, Ellingham T, Perlman EJ

Cancer research. 1999 ; 59 (12) : 2776-2780.

PMID 10383129

Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.

Lehman W, Hatch V, Korman V, Rosol M, Thomas L, Maytum R, Geeves MA, Van Eyk JE, Tobacman LS, Craig R

Journal of molecular biology. 2000 ; 302 (3) : 593-606.

PMID 10986121

Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms.

Ladanyi M

The American journal of pathology. 2000 ; 157 (2) : 341-345.

PMID 10934137

TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors.

Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL, Pinkus GS, Xiao S, Yi ES, Fletcher CD, Fletcher JA

The American journal of pathology. 2000 ; 157 (2) : 377-384.

PMID 10934142

Deciphering the design of the tropomyosin molecule.

Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C

Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (15) : 8496-8501.

PMID 11438684

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	08-2001	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . TPM4 (tropomyosin ). Atlas Genet Cytogenet Oncol Haematol. August 2001 . URL : http://AtlasGeneticsOncology.org/Genes/TPM4ID359.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:18:14 2008