TRAF4

Identity

Other names	MLN62
	CART1
HGNC	TRAF4
Location	17q11-q12
Local_order	TRAF4, Lasp1(alias MLN50), c-erbB2, MLN64, MLN51
	TRAF4 (17q11-q12) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are welcome : contact rocchi@biologia.uniba.it

DNA/RNA

Description	5,5 kb gene; 7 exons
Transcription	2 kb cDNA; coding sequence: 1410 bp

Protein

Description	470 amino acids; 53 kDa; contains an amino-terminal RING finger domain, a central stretch of six putative Zinc-binding domains (3 CART domains) and a carboxyl-terminal TRAF domain
Expression	epithelial cells; weak ubiquitous expression in adult tissues; stronger expression level in kidney and thymus
Localisation	cytoplasmic; nuclear when overexpressed
Function	putative signal transducer
Homology	to TRAF proteins (Tumor Necrosis Factor Receptor Associated Factor)

Implicated in

Entity	17q11-q12 gene amplification; found in about 25% of primary breast carcinomas
Prognosis	poor clinical outcome; increase risk of relapse

External links

	Nomenclature
HGNC	TRAF4   12034
Entrez_Gene	TRAF4  9618  TNF receptor-associated factor 4
	Cards
Atlas	TRAF4ID204
GeneCards	TRAF4
Ensembl	TRAF4 [Search_View]   ENSG00000076604 [Gene_View]
Genatlas	TRAF4
GeneLynx	TRAF4
eGenome	TRAF4
euGene	9618
	Genomic and cartography
GoldenPath	TRAF4  -     chr17:24095150-24102103 +  17q11-q21.3   [Description]    (hg18-Mar_2006)
Ensembl	TRAF4 - 17q11-q21.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TRAF4
	Gene and transcription
Genbank	AF082185 [ ENTREZ ]
Genbank	AY937222 [ ENTREZ ]
Genbank	AY937223 [ ENTREZ ]
Genbank	AY937224 [ ENTREZ ]
Genbank	BC001769 [ ENTREZ ]
RefSeq	NM_004295 [ SRS ]    NM_004295 [ ENTREZ ]
RefSeq	AC_000060 [ SRS ]    AC_000060 [ ENTREZ ]
RefSeq	AC_000149 [ SRS ]    AC_000149 [ ENTREZ ]
RefSeq	NC_000017 [ SRS ]    NC_000017 [ ENTREZ ]
RefSeq	NT_010799 [ SRS ]    NT_010799 [ ENTREZ ]
RefSeq	NW_001838430 [ SRS ]    NW_001838430 [ ENTREZ ]
RefSeq	NW_926750 [ SRS ]    NW_926750 [ ENTREZ ]
AceView	TRAF4 AceView - NCBI
Unigene	Hs.8375 [ SRS ]    Hs.8375 [ NCBI ]     HS8375 [ spliceNest ]
Fast-db	7227 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q2KJU4 [ SRS]    Q2KJU4 [ EXPASY ]     Q2KJU4 [ INTERPRO ]     Q2KJU4 [ UNIPROT ]
Prosite	PS00518 ZF_RING_1 [ SRS ]    PS00518 ZF_RING_1 [ Expasy ]
Prosite	PS50089 ZF_RING_2 [ SRS ]    PS50089 ZF_RING_2 [ Expasy ]
Prosite	PS50145 ZF_TRAF [ SRS ]    PS50145 ZF_TRAF [ Expasy ]
Interpro	IPR002083 MATH [ SRS ]    IPR002083 MATH [ EBI ]
Interpro	IPR013322 TRAF-type [ SRS ]    IPR013322 TRAF-type [ EBI ]
Interpro	IPR001841 Znf_RING [ SRS ]    IPR001841 Znf_RING [ EBI ]
Interpro	IPR013083 Znf_RING/FYVE/PHD [ SRS ]    IPR013083 Znf_RING/FYVE/PHD [ EBI ]
Interpro	IPR001293 Znf_TRAF [ SRS ]    IPR001293 Znf_TRAF [ EBI ]
CluSTr	Q2KJU4
Pfam	PF00917 MATH [ SRS ]    PF00917 MATH [ Sanger ]    pfam00917 [ NCBI-CDD ]
Pfam	PF00097 zf-C3HC4 [ SRS ]    PF00097 zf-C3HC4 [ Sanger ]    pfam00097 [ NCBI-CDD ]
Pfam	PF02176 zf-TRAF [ SRS ]    PF02176 zf-TRAF [ Sanger ]    pfam02176 [ NCBI-CDD ]
Smart	SM00184 RING [EMBL]
Blocks	Q2KJU4
HPRD	03915
	Protein Interaction databases
DIP	Q2KJU4
IntAct	Q2KJU4
	Polymorphism : SNP, mutations, diseases
OMIM	602464    [ map ]
GENECLINICS	602464
SNP	TRAF4 [dbSNP-NCBI]
SNP	NM_004295 [SNP-NCI]
SNP	TRAF4 [GeneSNPs - Utah]  TRAF4] [HGBASE - SRS]
HAPMAP	TRAF4 [HAPMAP]
COSMIC	TRAF4 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TRAF4
	General knowledge
Family Browser	TRAF4 [UCSC Family Browser]
SOURCE	NM_004295
SMD	Hs.8375
SAGE	Hs.8375
GO	DNA binding [Amigo]  DNA binding
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	signal transduction [Amigo]  signal transduction
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	zinc ion binding [Amigo]  zinc ion binding
GO	regulation of apoptosis [Amigo]  regulation of apoptosis
GO	metal ion binding [Amigo]  metal ion binding
PubGene	TRAF4
TreeFam	TRAF4
CTD	9618 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	Cancer Cytogenetics (Bari)
Probe	TRAF4 Related clones (RZPD - Berlin)
	PubMed
PubMed	21 Pubmed reference(s) in LocusLink

Bibliography

Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.

Tomasetto C, Rˆ©gnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC

Genomics. 1995 ; 28 (3) : 367-376.

PMID 7490069

Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma.

Rˆ©gnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC

The Journal of biological chemistry. 1995 ; 270 (43) : 25715-25721.

PMID 7592751

Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer.

Biˆ®che I, Tomasetto C, Rˆ©gnier CH, Moog-Lutz C, Rio MC, Lidereau R

Cancer research. 1996 ; 56 (17) : 3886-3890.

PMID 8752152

Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death.

Arch RH, Gedrich RW, Thompson CB

Genes & development. 1998 ; 12 (18) : 2821-2830.

PMID 9744859

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	08-2000	Catherine H Régnier, Catherine Tomasetto, Marie.Christine Rio
		I.G.B.M.C., BP163, 1 rue Laurent Fries, 67404 ILLKIRCH, France

Citation

This paper should be referenced as such :

Régnier CH, Tomasetto C, Rio MC . TRAF4. Atlas Genet Cytogenet Oncol Haematol. August 2000 . URL : http://AtlasGeneticsOncology.org/Genes/TRAF4ID204.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:18:16 2008