| Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. |
| Clark CC, Cohen I, Eichstetter I, Cannizzaro LA, McPherson JD, Wasmuth JJ, Iozzo RV. |
| Genomics 1993; 18: 249-260. |
| PMID 8288227 |
| |
| Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes. |
| Dealy CN, Roth A, Ferrari D, Brown AM, Kosher RA. |
| Mech Dev 1993; 43: 175-186. |
| PMID 8297789 |
| |
| Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis. |
| Moon RT, Campbell RM, Christian JL, McGrew LL, Shih J, Fraser S. |
| Development 1993; 119: 97-111. |
| PMID 8275867 |
| |
| Differential transformation of mammary epithelial cells by Wnt genes. |
| Wong GT, Gavin BJ, McMahon AP. |
| Mol Cell Biol 1994; 14: 6278-6286. |
| PMID 8065359 |
| |
| Aberrant expression of the growth factor Wnt-5A in human malignancy. |
| Iozzo RV, Eichstetter I, Danielson KG. |
| Cancer Res 1995; 55: 3495-3499. |
| PMID 7627953 |
| |
| Wnt5a cloning, expression, and up-regulation in human primary breast cancers. |
| Lejeune S, Huguet EL, Hamby A, Poulsom R, Harris AL. |
| Clin Cancer Res 1995; 1: 215-222. |
| PMID 9815976 |
| |
| A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. |
| Austin TW, Solar GP, Ziegler FC, Liem L, Matthews W. |
| Blood 1997; 89: 3624-3635. |
| PMID 9160667 |
| |
| Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. |
| Bui TD, Zhang L, Rees MC, Bicknell R, Harris AL. |
| Br J Cancer 1997; 75: 1131-1136. |
| PMID 9099960 |
| |
| A member of the Frizzled protein family mediating axis induction by Wnt-5A. |
| He X, Saint-Jeannet JP, Wang Y, Nathans J, Dawid I, Varmus H. |
| Science 1997; 275: 1652-1654. |
| PMID 9054360 |
| |
| Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A. |
| Slusarski DC, Yang-Snyder J, Busa WB, Moon RT. |
| Dev Biol 1997; 182: 114-120. |
| PMID 9073455 |
| |
| Identification of c-MYC as a target of the APC pathway. |
| He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW. |
| Science 1998; 281: 1509-1512. |
| PMID 9727977 |
| |
| Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. |
| Tetsu O, McCormick F. |
| Nature 1999; 398: 422-426. |
| PMID 10201372 |
| |
| A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. |
| Yamaguchi TP, Bradley A, McMahon AP, Jones S. |
| Development 1999; 126: 1211-1123. |
| PMID 10021340 |
| |
| Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas. |
| Jonsson M, Dejmek J, Bendahl PO, Andersson T. |
| Cancer Res 2002; 62: 409-416. |
| PMID 11809689 |
| |
| Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFa in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells. |
| Saitoh T, Katoh M. |
| Int J Mol Med 2002; 10: 345-349. |
| PMID 12165812 |
| |
| Frequent up-regulation of WNT5A mRNA in primary gastric cancer. |
| Saitoh T, Mine T, Katoh M. |
| Int J Mol Med 2002; 9: 515-519. |
| PMID 11956659 |
| |
| Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. |
| Weeraratna AT, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M, Trent JM. |
| Cancer Cell 2002; 1: 279-288. |
| PMID 12086864 |
| |
| Gene-expression profiling in human cutaneous melanoma. |
| Carr KM, Bittner M, Trent JM. |
| Oncogene 2003; 22: 3076-3080. |
| PMID 12789283 |
| |
| The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. |
| Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y. |
| Genes Cells 2003; 8: 645-654. |
| PMID 12839624 |
| |
| Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes. |
| Fujio Y, Matsuda T, Oshima Y, Maeda M, Mohri T, Ito T, Takatani T, Hirata M, Nakaoka Y, Kimura R, Kishimoto T, Azuma J. |
| FEBS Lett 2004 Aug; 573: 202-206. |
| PMID 15327998 |
| |
| FGF20 and DKK1 are transcriptional targets of beta-catenin and FGF20 is implicated in cancer and development. |
| Chamorro MN, Schwartz DR, Vonica A, Brivanlou AH, Cho KR, Varmus HE. |
| EMBO J 2005; 24: 73-84. |
| PMID 15592430 |
| |
| Expression pattern of Wnt signaling components in the adult intestine. |
| Gregorieff A, Pinto D, Begthel H, Destrée O, Kielman M, Clevers H. |
| Gastroenterology 2005; 129: 626-638. |
| PMID 16083717 |
| |
| WNT/PCP signaling pathway and human cancer. |
| Katoh M. |
| Oncol Rep 2005; 14: 1583-1588. (Review) |
| PMID 16273260 |
| |
| Comparative genomics on Wnt5a and Wnt5b genes. |
| Katoh M, Katoh M. |
| Int J Mol Med 2005; 15: 749-753. |
| PMID 15754042 |
| |
| Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1a signaling in human mammary epithelial cells. |
| Dejmek J, Säfholm A, Kamp Nielsen C, Andersson T, Leandersson K. |
| Mol Cell Biol 2006; 26: 6024-6036. |
| PMID 16880514 |
| |
| Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. |
| Mikels AJ, Nusse R. |
| PLoS Biol 2006; 4: e115. |
| PMID 16602827 |
| |
| Wnt5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. |
| Pukrop T, Klemm F, Hagemann T, Gradl D, Schulz M, Siemes S, Trumper L, Binder C. |
| Proc Natl Acad Sci USA 2006; 103: 5454-5459. |
| PMID 16569699 |
| |
| The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. |
| Dissanayake SK, Wade M, Johnson CE, O'Connell MP, Leotlela PD, French AD, Shah KV, Hewitt KJ, Rosenthal DT, Indig FE, Jiang Y, Nickoloff BJ, Taub DD, Trent JM, Moon RT, Bittner M, Weeraratna AT. |
| J Biol Chem 2007; 282:17259-17271. |
| PMID 17426020 |
| |
| STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis, and cancer. |
| Katoh M, Katoh M. |
| Int J Mol Med 2007; 19: 273-278. (Review). |
| PMID 17203201 |
| |
| Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth. |
| Roarty K, Serra R. |
| Development 2007; 134: 3929-3939. |
| PMID 17898001 |
| |
| Expression of WNT5A and its downstream effector beta-catenin in uveal melanoma. |
| Zuidervaart W, Pavey S, van Nieuwpoort FA, Packer L, Out C, Maat W, Jager MJ, Gruis NA, Hayward NK. |
| Melanoma Res 2007; 17: 380-386. |
| PMID 17992121 |
| |
| Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration |
| Cheng C, Yeh J, Fan T, Smith SK, Charnock-Jones DS. |
| Biochem Biophys Res Commun 2008; 365: 285-290. |
| PMID 17986384 |
| |
| Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. |
| Fukuda T, Chen L, Endo T, Tang L, Lu D, Castro JE, Widhopf GF 2nd, Rassenti LZ, Cantwell MJ, Prussak CE, Carson DA, Kipps TJ. |
| Proc Natl Acad Sci USA 2008; 105: 3047-3052. |
| PMID 18287027 |
| |
| Activation of Wnt signalling in stroma from pancreatic cancer identified by gene expression profiling. |
| Pilarsky C, Ammerpohl O, Sipos B, Dahl E, Hartmann A, Wellmann A, Braunschweig T, Lohr M, Jesnowski R, Friess H, Wente MN, Kristiansen G, Jahnke B, Denz A, Ruckert F, Schackert HK, Kloppel G, Kalthoff H, Saeger HD, Grutzmann R. |
| J Cell Mol Med 2008; in press. |
| PMID 18298655 |
| |
| Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. |
| Witze ES, Litman ES, Argast GM, Moon RT, Ahn NG. |
| Science 2008; 320: 365-369. |
| PMID 18420933 |
| |
| WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt/beta-catenin signaling, and is frequently methylated in colorectal cancer. |
| Ying J, Li H, Yu J, Ng KM, Poon FF, Wong SC, Chan AT, Sung JJ, Tao Q. |
| Clin Cancer Res 2008; 14: 55-61. |
| PMID 18172252 |
| |
