Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Chromosome 1

Chromosome 1 : G-banding, diagram and R-banding - Claude Léonard, Jean-Loup Huret

Leukaemia     

1q rearrangements in multiple myeloma
1p32 rearrangements
t(1;1)(p36;q21) in Non Hodgkin Lymphoma
t(1;2)(q25;p23)
t(1;2)(q12;q37)
t(1;3)(p36;q21)
t(1;3)(p36;p21)
t(1;3)(p32;p21)
t(1;5)(p32;q31)
t(1;5)(q21;q33) (MPD; TPM3/PDGFRB; rare)
t(1;5)(q22;q33)
t(1;6)(p35;p25)
t(1;7)(q10;p10)
t(1;7)(p36;q34)
t(1;7)(p34;q34)
t(1;7)(q21;q22)
t(1;7)(p32;q34)
t(1;8)(p22-p32;q22-q23)
t(1;9)(q24;q34)
t(1;11)(p32;q23) (AML, ALL; AF1P and MLL; not rare)
t(1;11)(q23;p15)
t(1;11)(q21;q23)
t(1;12)(q25;p13)
t(1;12)(p36;p13)
t(1;12)(q21;p13) (AML, ALL; ARNT and ETV6; rare)
t(1;13)(q32;q14)
t(1;14)(p32;q11)
t(1;14)(q21;q32) BCL9/IGH
t(1;14)(q21;q32) FCGR2B/IGH
t(1;14)(q21;q32) IRTA1/IGH
t(1;14)(q21;q32) MUC1/IGH
t(1;14)(q23;q32) (ALL, NHL, CLD; ---; rare)
t(1;14)(q25;q32)
t(1;14)(p22;q32) in non Hodgkin's lymphoma (NHL)
dic(1;15)(p11;p11)
t(1;16)(q11;q11)
t(1;16)(q12;q24)
t(1;18)(q25;q23)
t(1;18)(q10;q10)
t(1;19)(q23;p13)
t(1;19)(p13;p13.1)
t(1;21)(p36;q22)
t(1;21)(p32;q22)
t(1;21)(p35;q22)
t(1;21)(q21;q22)
t(1;22)(q21;q11)
t(1;22)(p13;q13)
t(Y;1)(q12;q12)

Solid Tumors     

inv(1)(q22;q25)
t(1;2)(q25;p23)
t(1;2)(q25;p23)
t(1;2)(q25;p23)
t(1;3)(q22;q12)
t(1;3)(p36;q25)
t(1;13)(p36;q14)
t(1;13)(p36;q14)
t(1;17)(p34;p13)
t(X;1)(p11;q21)

Cancer prone diseases     

Autoimmune Lymphoproliferative Syndrome
Glomuvenous malformation (GVM)
Hereditary Paraganglioma (PGL)
Hyperparathyroidism-Jaw Tumor syndrome (HPT-JT)
MAP (MUTYH-Associated Polyposis )
MUTYH associated polyposis

All Genes by Location (Kb)
Chromosome 1 by location

Losses / Amplicons     

BONE/SOFT TISSUE

External links     

  • Chromosome 1 - HUGO Chromosomes
  • Chromosome 1 - GoldenPath - Santa Cruz
  • Chromosome 1 - Ensembl Project
  • Chromosome 1 - Map View - NCBI
  • Chromosome 1 - GDB (Genome Data Base)
  • Chromosome 1 - OMIM Gene map
  • Chromosome 1 - Genomic Variants
  • Chromosome 1 - HAPMAP Project
  • Chromosome 1 - Genome Channel - ORNL
  • Chromosome 1 - LaunchPad HGMIS
  • Chromosome 1 - Human Protein Atlas
  • Chromosome 1 - SpliceNest
  • Human BAC Resource (NCBI)
  • FISH-mapped BACs (CCAP)
  • Genetic Maps (CHLC)
  • YACs mapped by FISH (Bari)
  • PCP (Partial Chromosome Paints) (Bari)
  • Positional Cloning Project (Berlin Dahlem)
  • Mouse homology - OMIM - NCBI
  • Cancer GeneWeb
  • GeneCards (Weizmann)
  • Human Proteomics Initiative (Expasy)

    • Genes

    Annotated genes
    SymbolLocation (Kb)Location (pter-qter)
    ABL2 177335.085 1q24-q25
    AKT3 241718.158 1q43-q44
    ARHGEF2 154183.270 1q21-q22
    ARNT 149048.810 1q21
    BCL9 145479.806 1q21
    CASP9 15691.384 1p36.3-p36.1
    CD53 111215.344 1p13
    CDC73 191357.784 1q25
    CENPF 212843.155 1q32-q41
    EGLN1 229568.054 1q42.1
    EPS15 51592.524 1p32
    FCGR2B 159899.564 1q23
    FH 239727.528 1q42.1
    GLMN 92484.545 1p22.1
    JUN 59019.053 1p32-p31
    KCNH1 208923.178 1q32-q41
    KIF14 198787.930 1q32.1
    LCK 32489.427 1p34.3
    LPHN2 82038.670 1p31.1
    MDS2 23826.410 1p36
    MIB2 1540.747 1p36.33
    MLLT11 149298.775 1q21
    MTHFR 11768.374 1p36.3
    MUTYH 45567.501 1p34.3-p32.1
    NOTCH2 120255.701 1p13-p11
    NRAS 115051.108 1p13.2
    PBX1 162795.561 1q23
    PDE4DIP 143601.948 1q12
    PRCC 155003.898 1q21.1
    PRDM16 2975.604 1p36.23-p33
    PRDM2 13903.937 1p36.21
    PRDX1 45749.295 1p34.1
    PTCH2 45060.675 1p33-p34
    PTGS2 184907.593 1q25.2-q25.3
    PVRL4 159308.120 1q22-q23.2
    RAP1A 111963.928 1p13.3
    RBM15 110683.468 1p13
    REG4 120138.232 1p13.1-p12
    RHOC 113045.272 1p13.1
    RPS6KA1 26728.836 1p
    S100A13 151857.904 1q21
    SDHB 17217.814 1p36.1-p35
    SDHC 159550.790 1q23.3
    SFPQ 35421.790 1p34.3
    STIL 47488.398 1q32|1p32
    TAL1 47454.551 1p32
    TNN 173303.617 1q23-q24
    TPM3 152394.404 1q21.2
    TPR 184547.411 1q25
    TSPAN1 46418.799 1p34.1
    VTCN1 117487.733 1p13.1
    Other genes
    possibly implicated
    in cancer
    SymbolLocation (Kb)Location (pter-qter)
    ACBD3 224399.005 1q42.12
    ACOT7 6246.920 1p36.31-p36.11
    ACTA1 227633.618 1q42.13-q42.2
    ADAM15 153290.386 1q21.3
    ADAM30 120237.679 1p13-p11
    ADAMTS4 159426.162 1q21-q23
    ADC 33319.301 -
    ADIPOR1 201176.576 1p36.13-q41
    ADORA3 111827.493 1p13.2
    ADSS 242638.420 1cen-q12
    AGMAT 15771.739 1p36.21
    AGRN 945.366 1p36.33
    AGT 228904.892 1q42-q43
    AIM1L 26520.959 1p36.11
    AIM2 157298.899 1q22
    AIR 30977.903 1p31
    AJAP1 4614.965 1p36.32
    AK2 33246.173 1p34
    AK5 77520.330 1p31
    AKR1A1 45789.085 1p33-p32
    AKR7A2 19503.051 1p35.1-p36.23
    AKR7A3 19481.644 1p35.1-p36.23
    ALDH4A1 19070.513 1p36
    ALDH9A1 163898.073 1q23.1
    ALPL 21708.445 1p36.1-p34
    AMPD1 115017.245 1p13
    AMPD2 109963.982 1p13.3
    ANGPTL1 177085.294 1q25.2
    ANGPTL3 62835.775 1p31.1-p22.3
    AOF2 23218.533 1p36.12
    APITD1 10412.746 1p36.22
    ARF1 226337.474 1q42
    ARHGAP29 94407.051 1p22.1
    ARHGEF10L 17738.917 1p36.13
    ARHGEF11 155171.257 1q21
    ARHGEF16 3369.982 1p36.3
    ARHGEF19 16397.186 1p36.13
    ARID1A 26895.109 1p35.3
    ARID4B 233396.834 1q42.1-q43
    ASH1L 153571.677 1q22
    ASPM 195319.997 1q31
    ATF3 210848.617 1q32.3
    ATF6 160002.708 1q22-q23
    ATG4C 63022.391 1p31.3
    ATP1B1 167342.571 1q24
    ATP6V0B 44213.189 1p32.3
    AURKAIP1 1298.973 1p36.33
    B4GALT2 44217.453 1p34-p33
    BAI2 31965.306 1p35
    BAT2D1 169721.290 1q23.3
    BCAR3 93799.938 1p22.1
    BCAS2 114911.706 1p21-p13.3
    BCL10 85504.050 1p22
    BCL2L15 114220.959 1p13.2
    BGLAP 154478.575 1q25-q31
    BLZF1 167603.818 1q24
    BMP6P1 45021.844 22q11.2
    BMP8B 39996.490 1p35-p32
    BNIPL 149275.658 1q21.2
    BRDT 92187.720 1p22.1
    BTG2 201541.287 1q32
    C1QA 22835.705 1p36.12
    C1orf102 36666.488 1p34.3
    C1orf124 229540.305 1q42.12-q43
    C1orf128 23977.475 1p36.11
    C1orf149 37730.763 1p35.3-p33
    C1orf159 1007.068 1p36.33
    C1orf38 28071.642 1p35.3
    C4BPA 205344.230 1q32
    CA6 8928.509 1p36.2
    CABC1 225194.561 1q42.13
    CACNA1E 179719.339 1q25-q31
    CACYBP 173235.515 1q24-q25
    CAMK1G 207823.668 1q32-q41
    CAMK2N1 20681.472 1p36.12
    CAMTA1 6767.971 1p36.31-p36.23
    CAPN2 221966.742 1q41-q42
    CAPN9 228949.784 1q42.11-q42.3
    CAPZB 19537.860 1p36.1
    CASZ1 10619.253 1p36.22
    CCDC18 93418.508 1p22.1
    CCT3 154545.376 1q23
    CD160 144407.155 1q21.1
    CD1A 156490.551 1q22-q23
    CD1C 156526.187 1q22-q23
    CD1D 156416.361 1q22-q23
    CD2 117098.609 1p13
    CD244 159066.574 1q23.3
    CD247 165666.508 1q22-q23
    CD34 206126.507 1q32
    CD46 205992.025 1q32
    CD48 158915.162 1q21.3-q22
    CD52 26516.998 1p36
    CD55 205561.488 1q32
    CD58 116858.680 1p13
    CDA 20788.031 1p36.2-p35
    CDC14A 100590.611 1p21
    CDC20 43597.213 1p34.1
    CDC2L1 1560.963 1p36.33
    CDC2L2 1624.030 1p36.33
    CDC42 22251.707 1p36.1
    CDC42BPA 225244.190 1q42.11
    CDC7 91739.032 1p22
    CDCA8 37930.746 1p34.3
    CDKN2C 51208.230 1p32
    CEP350 178190.531 1p36.13-q41
    CFH 194887.764 1q32
    CHD1L 145180.915 1q12
    CHD5 150997.130 3q13
    CHI3L1 201414.682 1q32.1
    CHIT1 201452.418 1q31-q32
    CITED4 41099.316 1p34.2|1p35-p34
    CKS1B 153213.838 1q21.2
    CLCA1 86707.114 1p31-p22
    CLCA2 86662.413 1p31-p22
    CLCN6 11788.794 1p36
    CLCNKA 16221.073 1p36
    CLIC4 24944.435 1p36.11
    CLK2 153499.284 1q21
    CLSPN 35974.407 1p34.2
    CNKSR1 26376.590 1p36.11
    CNR2 24073.048 1p36.11
    CNTN2 203278.963 1q32.1
    COL9A2 40538.750 1p33-p32
    COPA 158525.001 1q23-q25
    CPSF3L 1236.828 1p36.33
    CR1 205736.096 1q32
    CRABP2 154936.030 1q21.3
    CREB3L4 152207.021 1q21.3
    CREG1 165776.877 1q24
    CRNN 150648.343 1q21
    CRP 157948.704 1q21-q23
    CSF1 110254.980 1p21-p13
    CSF3R 36704.232 1p35-p34.3
    CSRP1 199719.283 1q32
    CTNNBIP1 9830.921 1p36.22
    CTPS 41217.594 1p34.1
    CTRC 15637.525 1p36.21
    CTSE 204484.082 1q31
    CTSK 149035.311 1q21
    CYP2J2 60131.569 1p31.3-p31.2
    CYP3A 60131.571 7q21.3-q22.1
    CYP4A11 47167.433 1p33
    CYP4B1 47037.257 1p34-p12
    CYP4Z1 47305.747 1p33
    CYR61 85819.048 1p31-p22
    DAP3 153925.498 1q21-q22
    DARC 157441.134 1q21-q22
    DCLRE1B 114249.561 1p13.2
    DDEFL1 23627.643 1p36.12
    DDOST 20850.847 1p36.1
    DDR2 160868.852 1q23.3
    DDX20 112099.777 1p21.1-p13.2
    DENND2D 111531.324 1p13.3
    DFFA 10443.192 1p36.3-p36.2
    DFFB 3763.705 1p36.3
    DHCR24 55087.888 1p33-p31.1
    DHX9 181075.074 1q25
    DIO1 54132.449 1p33-p32
    DIRAS3 68284.235 1p31
    DISC1 229829.184 1q42.1
    DKFZp566H0824 8363.007 1p36.23
    DLEU2L 63787.238 1p31-p22
    DMAP1 44451.712 1p34
    DNAJB4 78243.224 1p31.1
    DNAJC11 6616.818 1p36.31
    DNAJC16 15725.939 1p36.1
    DNAJC6 65503.018 1pter-q31.3
    DNALI1 37795.107 1p35.1
    DPYD 97315.888 1p22
    DUSP10 219941.389 1q41
    DVL1 1260.521 1p36
    DYRK3 204875.504 1q32.1
    E2F2 23705.509 1p36
    ECE1 21417.664 1p36.1
    ECM1 148747.207 1q21
    EDG1 101475.043 1p21
    EDG7 85052.089 1p22.3-p31.1
    EDN2 41717.036 1p34
    EFNA1 153366.973 1q21-q22
    EIF3I 32460.558 1p34.1
    EIF4G3 21005.563 1p36.12
    ELA3A 22200.736 1p36.12
    ELAVL4 50347.225 1p34
    ELF3 200243.696 1q32.2
    ELK4 203855.021 1q32
    ENAH 223741.157 1q42.12
    ENO1 8843.650 1p36.3-p36.2
    EPB41 29086.215 1p33-p32
    EPHA10 37954.233 1p34.3
    EPHA2 16323.420 1p36
    EPHA8 22762.591 1p36.12
    EPHB2 22909.918 1p36.1-p35
    EPHX1 224079.599 1q42.1
    ERMAP 43063.836 1p34.2
    ERRFI1 7994.382 1p36
    ESRRG 214743.211 1q41
    ETV3 155369.602 1q21-q23
    ETV3L 155328.460 1q23.1
    EVI5 92746.842 1p22.1
    EXO1 240078.158 1q42-q43
    EXTL1 26220.858 1p36.1
    EXTL2 101110.529 1p21
    F11R 159232.608 1q21.2-q21.3
    F3 94767.461 1p22-p21
    F5 167747.816 1q23
    FABP3 31610.687 1p33-p32
    FAF1 50679.523 1p33
    FAIM3 205144.354 1q32.1
    FAM129A 183026.791 1q25
    FAM5C 188333.420 1q31.1
    FASLG 170894.808 1q23
    FBLIM1 15964.046 1p36.21
    FBXO42 16449.147 1p36.23-p36.11
    FBXO6 11646.768 1p36.23-p36.11
    FCER1A 157526.128 1q23
    FCGR2A 159741.844 1q23
    FCGR3A 159778.175 1q23
    FCGR3B 159859.612 1q23
    FCRL4 155810.164 1q21
    FCRL5 155749.791 1q21
    FCRLA 159943.386 1q23.3
    FDPS 153546.201 1q22
    FGR 27811.389 1p36.2-p36.1
    FLVCR1 211098.220 1q32.3
    FMO1 169484.287 1q23-q25
    FMO3 169326.660 1q23-q25
    FMO4 169550.110 1q23-q25
    FMO5 145124.462 1q21.1
    FMOD 201576.376 1q32
    FOXD2 47674.276 1p34-p32
    FOXD3 63561.318 1p32-p31
    FOXE3 47654.331 1p32
    FOXJ3 42414.798 1pter-q31.3
    FRAP1 11089.180 1p36.2
    FUCA1 24044.161 1p34
    FUSIP1 24168.160 1p36.11
    G0S2 207915.388 1q32.2-q41
    GADD45A 67923.471 1p31.2-p31.1
    GALE 23994.676 1p36-p35
    GBP2 89345.898 1p22.2
    GBP5 89498.853 1p22.2
    GCLM 94125.178 1p22.1
    GDAP2 118213.563 1p12
    GFI1 92712.910 1p22
    GJA4 35031.186 1p35.1
    GLRX2 191332.223 1q31.2-q31.3
    GLUL 180618.292 1q31
    GNAI3 109892.824 1p13
    GNAT2 109947.413 1p13.1
    GNB1 1706.590 1p36.33
    GNG12 67939.737 1p31.3
    GNG4 233777.608 1q42.3
    GNG5 84736.680 1p22
    GNRHR2 144225.777 1q12
    GPA33 165288.706 1q24.1
    GPSM2 109221.350 1p13.3
    GPX7 52840.632 1p32
    GSTM1 110031.965 1p13.3
    GSTM2 110012.214 1p13.3
    GSTM3 110078.077 1p13.3
    GSTM4 110000.226 1p13.3
    GSTM5 110056.388 1p13.3
    GUCA2A 42400.949 1p35-p34
    H6PD 9217.450 1p36
    HBXIP 110745.402 1p13.3
    HCRTR1 31857.228 1p33
    HDAC1 32530.295 1p34
    HDGF 154978.526 1q21-q23
    HECTD3 45240.807 1p34.1
    HEJ1 102110.154 1p22
    HES2 6397.883 1p36.31-p36.11
    HES4 924.208 1p36.33
    HES5 2450.044 1p36.32
    HHAT 208568.920 1q32
    HHCM 227473.504 8q24.3
    HIPK1 114298.022 1p13.2
    HIST2H2AB 148125.644 1q21
    HIST2H3A 148090.805 1q21.2
    HIST3H3 226679.169 1q42
    HMGN2 26671.489 1p36.1
    HNRNPR 23508.863 1p36.12
    HNRNPU 243080.225 1q44
    HSD11B1 207926.173 1q32-q41
    HSD17B7 161027.120 1q23
    HSD3B1 119851.349 1p13.1
    HSD3B2 119759.296 1p13.1
    HSP90B3P 91873.155 1p22.2
    HSPA6 159760.660 1q23
    HSPB7 16213.112 1p36.23-p34.3
    HSPC157 22224.613 1p36.12
    HSPG2 22021.324 1p36.1-p34
    HTR1D 23390.976 1p36.3-p34.3
    HYI 43689.416 1p34.2
    ID3 23756.996 1p36.13-p36.12
    IER5 179324.261 1q25.3
    IFI16 157246.306 1q22
    IGHJ@ 85819.005 14q32.32-q32.33
    IGSF8 158327.754 1q23.1
    IKBKE 204710.419 1q32.1
    IL10 205007.571 1q31-q32
    IL12RB2 67545.635 1p31.3-p31.2
    IL20 205105.777 1q32
    IL23R 67404.757 1p31.3
    IL24 205137.412 1q32
    IL6R 152644.293 1q21
    INPP5B 38098.956 1p34
    INSRR 155077.290 1q21-q23
    IQCC 32443.859 1p36.11-p34.2
    ISG15 938.742 1p36.33
    ITGA10 144236.347 1q21
    ITGB3BP 63679.050 1p31.3
    ITLN1 159112.956 1q22-q23.5
    ITPKB 224886.015 1q42.13
    JAK1 65071.495 1p32.3-p31.3
    JARID1B 200963.156 1q32.1
    JMJD2A 43888.384 1p34.1
    JMJD4 225985.558 1q42.13
    JST 150997.130 -
    JTB 152213.369 1q21
    KCNA3 111015.833 1p13.3
    KCND3 112119.977 1p13.3
    KCNJ9 158317.984 1q21-q23
    KCTD3 213807.358 1q41
    KHDRBS1 32252.078 1p32
    KIAA0090 19417.172 1p36.13
    KIAA0562 3721.204 1p36.32
    KIAA1245 143309.866 1q21.2
    KIAA1324 109458.056 1p13.3
    KIF1B 10193.418 1p36.2
    KIF2C 44978.138 1p34.1
    KISS1 202426.093 1q32
    KLHL21 6573.372 1p36.31
    LAMB3 207854.841 1q32
    LAMC1 181259.218 1q31
    LAMC2 181421.797 1q25-q31
    LEFTY1 224140.606 1q42.1
    LEFTY2 224190.927 1q42.1
    LEMD1 203617.136 1q32.1
    LEPR 65658.906 1p31
    LEPRE1 42984.633 1p34.1
    LGALS8 234753.362 1q42-q43
    LHX4 178466.065 1q25.2
    LIN28 26609.856 1p36.11
    LIN9 224485.488 1q42.12
    LMNA 154351.085 1q21.2-q21.3
    LMO4 87566.739 1p22.3
    LNCR1 150997.130 6q23-q25
    LOC390998 6226.232 1p36.22
    LOC91219 152231.790 22q11.22
    LRRC8D 90060.101 1p22.2
    LRRN2 202852.928 1q32.1
    LSL 201541.287 2p21
    MAD2L2 11657.125 1p36
    MAGI3 113734.998 1p12-p11.2
    MAP3K6 27554.257 1p36.11
    MAPBPIP 154291.229 1q22
    MAPKAPK2 204924.912 1q32
    MARCKSL1 32572.028 1p35.1
    MASP2 11027.443 1p36.3-p36.2
    MCL1 148813.661 1q21
    MDM4 202752.134 1q32
    MED18 28528.136 1p35.3
    MEF2D 154700.144 1q12-q23
    MEX3A 154308.428 1q22
    MFAP2