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Chromosome 21

Chromosome 21 : G-banding, diagram and R-banding - Claude Léonard, Jean-Loup Huret

Leukaemia     

t(1;21)(p36;q22)
t(1;21)(p32;q22)
t(1;21)(p35;q22)
t(1;21)(q21;q22)
t(2;21)(p11;q22)
t(3;21)(q26;q22)
t(3;21)(q26;q22) in treatment related leukemia
t(4;21)(q31;q22)
t(4;21)(q31;q22)
t(5;21)(q13;q22)
t(6;21)(p22;q22)
t(7;21)(p22;q22)
t(8;21)(q22;q22)
t(8;21)(q22;q22) in treatment related leukemia
t(8;21)(q24;q22)
t(9;21)(p22;q22)
t(9;21)(q34;q22)
t(X;21)(q26;q22) (AML; ELF4 and ERG; rare)
t(X;21)(p22;q22)
t(12;21)(p12;q22)
t(12;21)(q12;q22)
t(12;21)(q24;q22)
t(14 ;21)(q11;q22)
t(14;21)(q22;q22)
t(15;21)(q22;q22)
t(16;21)(p11;q22)
t(16;21)(q24;q22)
t(17;21)(q11.2;q22)
t(18;21)(q21;q22)
t(19;21)(q13.4;q22)
t(20;21)(q11;q22)
t(20;21)(q13;q22)
21q22 rearrangements in treatment related leukemia
dup(21q) amplified (RUNX1)
-21 or monosomy 21 (solely)
+21 or trisomy 21

Solid Tumors     

t(16;21)(p11;q22)
t(21;22)(q12;q12)
t(17;22)(q12;q12)

Cancer prone diseases     

All Genes by Location (Kb)
Chromosome 21 by location

Losses / Amplicons     

BONE/SOFT TISSUE

External links     

  • Chromosome 21 - HUGO Chromosomes
  • Chromosome 21 - GoldenPath - Santa Cruz
  • Chromosome 21 - Ensembl Project
  • Chromosome 21 - Map View - NCBI
  • Chromosome 21 - GDB (Genome Data Base)
  • Chromosome 21 - OMIM Gene map
  • Chromosome 21 - Genomic Variants
  • Chromosome 21 - HAPMAP Project
  • Chromosome 21 - Genome Channel - ORNL
  • Chromosome 21 - LaunchPad HGMIS
  • Chromosome 21 - Human Protein Atlas
  • Chromosome 21 - SpliceNest
  • Human BAC Resource (NCBI)
  • FISH-mapped BACs (CCAP)
  • Genetic Maps (CHLC)
  • YACs mapped by FISH (Bari)
  • PCP (Partial Chromosome Paints) (Bari)
  • Positional Cloning Project (Berlin Dahlem)
  • Mouse homology - OMIM - NCBI
  • Cancer GeneWeb
  • GeneCards (Weizmann)
  • Human Proteomics Initiative (Expasy)

    • Genes

    Annotated genes
    Ordered by Name Ordered by Location
     Kb pter-qter
    OLIG2 33320.109 21q22.11
    RUNX1 35081.969 21q22.3
    ERG 38675.671 21q22.3
    TFF3 42605.233 21q22.3
    TFF2 42639.538 21q22.3
    TFF1 42655.462 21q22.3
    TMPRSS3 42665.069 21q22.3
    PTTG1IP 45093.941 21q22.3
    S100B 46842.959 21q22.3
    Other genes
    possibly implicated
    in cancer
    Ordered by Name Ordered by Location
     Kb pter-qter
    BAGE2 10042.713 21p
    BAGE3 10042.713 21p11.2
    BAGE4 10042.713 21p11.1
    BAGE5 10042.713 13cen
    BAGE 10079.667 21p11.1
    RAD23BLP 14510.350 21q11
    STCH 14665.310 21q11.1|21q11
    SAMSN1 14779.420 21q11
    NRIP1 15255.427 21q11.2
    USP25 16024.367 21q11.2
    CXADR 17807.201 21q21.1
    BTG3 17887.843 21q21.1-q21.2
    PRSS7 18563.561 21q21|21q21.1
    NCAM2 21292.504 21q21.1
    MIRN155 25856.375 21q21.3
    GABPA 26029.570 21q21-q22.1|21q21.3
    APP 26174.733 21q21.2|21q21.3
    CYYR1 26760.400 21q21.2
    ADAMTS1 27130.479 21q21.2
    ADAMTS5 27212.113 21q21.3
    BACH1 29593.091 21q22.11
    CLDN8 30508.201 21q22.11
    PRCA1 30773.889 -
    RAB42P 30895.285 -
    TIAM1 31412.607 21q22.1|21q22.11
    SOD1 31953.806 21q22.1|21q22.11
    HUNK 32167.499 21q22.1
    SYNJ1 32922.944 21q22.2
    OLIG1 33364.443 21q22.11
    IFNAR2 33524.101 21q22.1|21q22.11
    IFNAR1 33619.084 21q22.1|21q22.11
    IFNGR2 33697.072 21q22.11
    SON 33837.220 21q22.1-q22.2|21q22.11
    ITSN1 33936.654 21q22.1-q22.2
    SLC5A3 34367.740 21q22.12
    KCNE1 34740.859 21q22.1-q22.2|21q22.12
    CBR3 36429.133 21q22.2
    CHAF1B 36679.559 21q22.13
    SIM2 36993.861 21q22.2|21q22.13
    PIGP 37359.534 21q22.2
    DYRK1A 37661.729 21q22.13
    KCNJ6 37918.657 21q22.1|21q22.13-q22.2
    DSCR8 38415.415 21q22.2
    ETS2 39099.719 21q22.3|21q22.2
    HMGN1 39636.117 21q22.3|21q22.2
    B3GALT5 39951.124 21q22.3
    BACE2 41461.598 21q22.3
    TMPRSS2 41758.351 21q22.3
    RIPK4 42032.598 21q22.3
    PKNOX1 43267.712 21q22.3
    CBS 43346.372 21q22.3
    U2AF1 43386.136 21q22.3
    SNF1LK 43658.829 21q22.3
    RRP1B 43903.860 21q22.3
    CSTB 44018.260 21q22.3
    C21orf33 44377.922 21q22.3
    ICOSLG 44471.152 21q22.3
    DNMT3L 44490.651 21q22.3
    AIRE 44534.576 21q22.3
    PFKL 44544.358 21q22.3
    UBE2G2 45013.384 21q22.3
    ITGB2 45130.299 21q22.3
    ADARB1 45318.943 21q22.3
    COL18A1 45649.525 21q22.3
    SLC19A1 45759.057 21q22.3
    PCBP3 46094.303 21q22.3
    COL6A1 46226.091 21q22.3
    MCM3AP 46479.476 21q22.3
    PCNT 46568.483 21q22.3
    PRMT2 46879.955 21q22.3

    GeneCards   GDB - List of genes

    This page should be referenced as such :
    Dessen P, Knuutila S, Huret JL Chromosome 21. Atlas Genet Cytogenet Oncol Haematol. 2002.
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_21.html
    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Tue Jul 1 08:54:04 2008
    Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case reports   Journals   Portal   Teaching   

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