CASE REPORTS in HAEMATOLOGY (Paper co-edited with the European LeukemiaNet)

Translocation t(1;6)(p35;p25) in B-cell lymphoproliferative disorder with evolution to Diffuse Large B-cell Lymphoma

Elvira D Rodrigues Pereira Velloso, Cristina Ratis, Sérgio A B Brasil, João Carlos Guerra, Nydia Bacal; Cristóvão P Mangueira LM Pitangueira

Clinics

Age and sex :	75 year(s) old female patient.
Previous History :	B- cell Lymphoproliferative disorder for 8 years
Organomegaly :	hepatomegaly ; splenomegaly ; enlarged lymph nodes ; no central nervous system involvement

Blood

WBC : 5,4 x 109/l; Hb : 13,6 g/dl; platelets : 169 x 109/l; blasts : 3,35% (x 109/l (lymphoid cells))

Bone marrow : 28% ( of lymphoid mature cells)

Cyto pathology classification

Cytology : B-cell Lymphoproliferative disorder (Atypical CLL) with evolution to diffuse large B-cell Lymphoma. Atypical CLL.

Immunophenotype : 25% of total bone marrow cells are positive : CD20++, CD22+, CD25+, CD38, CD79b++, HLA-DR, sIgM, sIgD e sKappa ++.

Rearranged Ig Tcr : not done

Pathology : Inguinal Lymph node biopsy (August, 2005): Diffuse large B-cell Lymphoma, Ki-67: 70%, ciclina D1 -, CD20 +, BCL2 +.

Electron microscopy : not done

Precise diagnosis : B-cell Lymphoproliferative disorder (Atypical CLL) with evolution to diffuse large B-cell Lymphoma.

Survival

Date of diagnosis: (07-2007)

Treatment : wide previous history (long previous history of chemotherapy), no chemotherapy after July, 2007

Complete remission : None

Treatment related death : -

Relapse : -

Status : Alive 09-2007

Survival : 2 month(s)

Karyotype

Sample : bone marrow cells ; culture time : 72 h, ours with and without TPA (o-tetradecanoyl phorbol-13-acetate) ; banding : G

Results : 47,XX, t(1;6) (p35;p25),+12[13]/46,XX[7]

Karyotype at relapse : not done

Other molecular cytogenetics technics : not done

Other molecular studies

technics : not done

Partial karyotype, G- band

Comments

In 2005, the Belgian group described the t(1;6)(p35.3;p25.2) in 8 patients with unmutated B-CLL. As in this case, this rare cytogenetic entity has been described in typical or atypical CLL (8/8 cases), with evolution to diffuse large B-cell Lymphoma (3/8 cases); trisomy 12 been a common additional abnormality (3/8 cases).

Internal links

Atlas Card

t(1;6)(p35;p25)

Bibliography

Translocation t(1;6)(p35.3;p25.2): a new recurrent aberration in "unmutated" B-CLL.

Michaux L, Wlodarska I, Rack K, Stul M, Criel A, Maerevoet M, Marichal S, Demuynck H, Mineur P, Kargar Samani K, Van Hoof A, Ferrant A, Marynen P, Hagemeijer A.

Leukemia 2005; 19: 77-82.

PMID 15510210

Contributor(s)

Written

07-2007

Elvira D Rodrigues Pereira Velloso, Cristina Ratis, Sérgio A B Brasil, João Carlos Guerra, Nydia Bacal; Cristóvão P Mangueira LM Pitangueira

Citation

This paper should be referenced as such :

Rodrigues Pereira Velloso ED, Ratis . Translocation t(1;6)(p35;p25) in B-cell lymphoproliferative disorder with evolution to Diffuse Large B-cell Lymphoma. Atlas Genet Cytogenet Oncol Haematol. July 2007 . URL : http://AtlasGeneticsOncology.org/Reports/0106RodriguesID100030.html

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indexed on : Thu Apr 17 14:15:17 2008

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