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11p15/NUP98 project: Form for submission of Case Reports

This is in collaboration with the European LeukemiaNet - Workpackage 11: Cytogenetics


This section is dedicated to any case with a 11p15 breakpoint (except the well known t(7;11)(p15;p15)), AND a diagnosis of acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), borderline between myelodysplastic syndrome and myeloproliferative disorder (MDS/MPD) (WHO Classification), or chronic myeloid leukemia in blastic phase (BP-CML)

  1. with well documented clinics and laboratory findings, and
  2. iconography on chromosomes,
  3. Molecular studies -to prove or discard NUP98 involvement- should be done or in progress at the time of submission of this paper.

For Molecular studies, if needed, contact: Cristina Mecucci or Serge Romana. They are willing to search for new NUP98 partners. Therefore, are excluded from their study -but not from this 11p15/Case Report section- partner breakpoints at: 1q23(PMX1), 2q31(HOXD11, HOXD13), 4q21(RAP1GDS1), 5q35(NSD1), 8p11(NSD3), 9p22(LEDGF), 10q25(ADD3), 11q22(DDX10), 12q13(HOXC11, HOXC13), 20q11(TOP1) and, obviously, 7p15(HOXA9), the latter being also excluded from this 11p15/Case Report section.

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Select all, copy and past this form in a ClarisWorks or Word file, save as a model, ... ready for use

IMPORTANT INSTRUCTIONS TO AUTHORS:

1- Please send example(s) of the chromosome rearrangement for the reviewers and for the publication: in NO case will a paper be accepted without the chromosome and/or FISH necessary ascertainment. Images can be sent either printed by traditional mail, or by e-mail; in the latter, use preferably BMP, GIF, JPG, or ClarisWorks formats; the desk may have problems with other formats.
2- Please send (by post) a copy of the papers cited to speed the review process.
3- Please, suggest 2 referees, with complete address (e- mails in particular).
4- Please, certify herein that this case report has not previously been published (or with no data).

Note : The Atlas is indexed in the Current Contents, and case reports in the Atlas are recorded in Mitelman's database of Chromosome Aberrations in Cancer .
A case published in the Atlas must therefore be indicated as such, when published again as part of a larger series (in order to avoid double publications of the same case in Mitelman's database).

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TITLE (must be plain and explicit)

AUTHORS

AUTHORS AFFILIATIONS / e-MAIL

DATE 

CASE' s HOSPITAL NUMBER (Unique Identif. Nb is required; no recognizable item ++)
 


 

 Previous History ------->

OF  PRELEUKAEMIA (+/-)

OR PREVIOUS MALIGNANT DISEASE (+/-)

OR INBORN GENETIC CONDITION (+/-)

IF +, MAIN ITEMS ARE 





 Clinics ------->
      
AGE (d: days; m: months; y: years)
  
SEX (M/F)

ENLARGED LIVER (+/-)
        
ENLARGED SPLEEN (+/-)
       
ENLARGED LYMPH NODES (+/-)
          
CENTRAL NERVOUS SYST INVOLVED (+/-)



        

 Blood Data ------->
 
WBC (109/l)
      
Hb (g/dl)
   
PLATELETS (109/l)
        
BLASTS (%)

BONE MARROW





 Cyto-Pathological Classification  ------->

PHENOTYPE (FAB)
     
IMMUNOPHENOTYPE (as CD)
     
REARRANGED (+/-) IG or TCR (which)
                         
PATHOLOGY

PRECISE DIAGNOSIS





 Survival Data ------->

DATE OF DIAGNOSIS (month/year)
      
TREATMENT

COMPLETE REMISSION (+/-)

DEATH RELATED WITH TREATMENT (+/-)

RELAPSE (+/-)

IF RELAPSE: PHENOTYPE
       
DATE OF LAST FOLLOW UP (m/y)
        
DEAD (D), ALIVE (A), LOST (L)
       
SURVIVAL (d, m, or y)
       




 Karyotype ------->

SAMPLE
          
CULTURE TIME
          
BANDING
     
DETAILED COMPLETE RESULTS (using ISCN)

KARYOTYPE(S) AT RELAPSE(S)





 Molecular Cytogenetics ------->

TECHNICS

RESULTS





 Other Molecular Studies ------->

TECHNICS

RESULTS





 Other Findings ------->

MAIN ITEMS





 Iconography ------->

LEGEND TO TEXT FIGURE 1

LEGEND TO TEXT FIGURE 2

LEGEND TO TEXT FIGURE 3

LEGEND TO TEXT FIGURE 4





 Comments    ------->

COMMENTS (no more than 10 lines; make sure of relevance)



 References  (1- as few as possible, 2- PLEASE, see below and conform to the style) ------->  


TITLE 

AUTHORS  

REFERENCE 

MEDLINE 


Copy and past another bloc 

TITLE 

AUTHORS  

REFERENCE 

MEDLINE 



... and again ...
_________________________________________________________________________

- Style to be used for References:
* classified by years, from the oldest to the most recent, and by alphabetical order within a year
* style: - Please, send your contribution preferably by e-mail (Copy-and-past directly in the mail, and/or as an attachment, in ClarisWorks or in Word). Please, no printed version solely.

Send to:
Jean-Loup HURET,
Atlas Genet Cytogenet Oncol Haematol, Editor,
Genetics, Dept Medical Information,
University Hospital, F-86021 Poitiers, FRANCE
tel +33 5 49 44 45 46 or +33 5 49 44 47 67
j.l.huret@chu-poitiers.fr AND Copy Carbone jlhuret@infobiogen.fr