CASE REPORTS in HAEMATOLOGY (Paper co-edited with the European LeukemiaNet)

Dic(1;15)(p11;p11) as a non-random abnormality in essential thrombocytemia

Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Clinics

Age and sex :	74 year(s) old female patient.
Previous History :	no preleukemia
	no previous malignant disease
	no inborn condition of note
Organomegaly :	no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement

Blood

WBC : 16.4 x 109/l; Hb : 16.3 g/dl; platelets : 872 x 109/l;

Cyto pathology classification

Cytology : -

Immunophenotype : -

Rearranged Ig Tcr : -

Pathology : MPD

Electron microscopy : -

Precise diagnosis : Essential Thrombocytemia

Survival

Date of diagnosis: 03-1997

Treatment : Hydroxyurea

Complete remission : None

Treatment related death : -

Relapse : -

Status : Dead 02-2008

Survival : 131 month(s)

Karyotype

Sample : bone marrow ; culture time : 48 h ; banding : GTG

Results : 46,XX,[3]/46,XX,-15,+dic(1;15)(p11;p11)[10]

Karyotype at relapse : NA

Other molecular cytogenetics technics : NA

Other molecular studies

technics : NA

Other findings

results : NA

Karyotype at diagnosis presenting the dic(1;15)(p11;p11) as sole abnormality.

Comments

This is an additional MPD case presenting this recurrent abnormality, with 11 years survival. However the death is not related to the disease (cardiac failure) in this case.

Internal links

Atlas Card	dic(1;15)(p11;p11)
Case Report	Dic(1;15)(p11;p11) as a non-random abnormality in atypical MPD
Case Report	Dic(1;15)(p11;p11) as a non-random abnormality in Polycytemia Vera
Case Report	Dic(1;15)(p11;p11) as a non-random abnormality in Myelodysplasic syndrome

Contributor(s)

Written

05-2008

Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Citation

This paper should be referenced as such :

Theisen O, Richebourg S, Lai JL, Roche-Lestienne C . Dic(1;15)(p11;p11) as a non-random abnormality in essential thrombocytemia. Atlas Genet Cytogenet Oncol Haematol. May 2008 . URL : http://AtlasGeneticsOncology.org/Reports/dic115inETRocheID100036.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Sep 24 21:09:52 2008

For comments and suggestions or contributions, please contact us