CASE REPORTS in HAEMATOLOGY (Paper co-edited with the European LeukemiaNet)

Dic(1;15)(p11;p11) as a non-random abnormality in Polycytemia Vera

Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Clinics

Age and sex :	72 year(s) old female patient.
Previous History :	no preleukemia
	no previous malignant disease
	no inborn condition of note
Organomegaly :	no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement

Blood

WBC : 6.5 x 109/l; Hb : 19 g/dl; platelets : 350 x 109/l;

Cyto pathology classification

Cytology : -

Immunophenotype : -

Rearranged Ig Tcr : -

Pathology : MPD, PV

Electron microscopy : -

Precise diagnosis : Polycytemia vera.

Survival

Date of diagnosis: 07-1990

Treatment : Hydroxyurea

Complete remission was obtained

Treatment related death : -

Relapse : +

Phenotype at relapse : AML with unknown phenotype due to bone marrow aspiration failure.

Status : Dead 09-2001

Survival : 134 month(s)

Karyotype

Sample : bone marrow ; culture time : 48 h ; banding : RHG

Results : 46,XX,-15,+dic(1;15)[13]

Karyotype at relapse : 46,XX,del(7)(q22;q34),-15,+dic(1;15)(p11;p11)[18]

Other molecular cytogenetics technics : NA

Other molecular studies

technics : NA

Karyotype at diagnosis presenting the isolated dic(1;15)(p11;p11).

Comments

This is an additional MPD case presenting this recurrent abnormality, with 11 years survival. However in this case the death is related to disease (respiratory distress on leukostasis).

Internal links

Atlas Card	dic(1;15)(p11;p11)
Case Report	Dic(1;15)(p11;p11) as a non-random abnormality in essential thrombocytemia
Case Report	Dic(1;15)(p11;p11) as a non-random abnormality in atypical MPD
Case Report	Dic(1;15)(p11;p11) as a non-random abnormality in Myelodysplasic syndrome

Contributor(s)

Written

05-2008

Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Citation

This paper should be referenced as such :

Theisen O, Richebourg S, Lai JL, Roche-Lestienne C . Dic(1;15)(p11;p11) as a non-random abnormality in Polycytemia Vera. Atlas Genet Cytogenet Oncol Haematol. May 2008 . URL : http://AtlasGeneticsOncology.org/Reports/dic115inPVRocheID100038.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Sep 24 21:09:54 2008

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