Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CASE REPORTS in HAEMATOLOGY
A case of pre-B ALL with t(8;14)(q11;q32)
Gitte Birk Kerndrup, Steen Rosthøj
 
Clinics
Age and sex : 11 year(s) old male patient.
Previous History : no preleukemia
no previous malignant disease
no inborn condition of note
Organomegaly : hepatomegaly ; splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement
Blood
WBC : 4.3 x 109/l; Hb : 3.3 g/dl; platelets : 16 x 109/l; blasts : 2%
Bone marrow : 99% (blasts)
Cyto pathology classification
Cytology : ALL-L1
Immunophenotype : CD19+/CD10+/Tdt+
Rearranged Ig Tcr : IgH: +, TCR: +
Precise diagnosis : pre-B ALL
Survival
Date of diagnosis: 08-2000
Complete remission was obtained
Status : Alive
Survival : 10 month(s)
Karyotype
Sample : Peripheral blood sample ; culture time : 24 h, culture ; banding : G-banding
Results : 49,XY,+X,t(8;14)(q11;q32),+12,+21[15]/46,XY[10]
t(8;14)(q11;q32) G- banding - Gitte Birk Kerndrup, Steen Rosthøj
Comments
This case, an eleven year old boy does not have Down syndrome or other inborn genetic conditions. His spleen and liver were remarkably enlarged (spleen: to the umbilical plane, liver: 4 fingers below the costal margin). He had no lymph node involvement, nor CNS- or testis disease. He did not, on flowcytometric immune phenotyping, show evidence of bilineage differentation. The phenotype was the usual for a pre-B ALL (CD10+/CD19+/Tdt+).
Internal links
Atlas Cardt(8;14)(q11;q32)
Case ReportA case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32)
Case ReportA new case of t(8;14)(q11;q32) in an acute lymphoblastic leukemia
Bibliography
t(8;14)(q11;q32).
Huret JL
Atlas Genet Cytogenet Oncol Haematol. November 1999; URL : http://www.infobiogen.fr/services/chromcancer/Anomalies/t0814ID1112.html
 
Acute lymphoblastic leukemia wit an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group Study.
Kaleem Z, Shuster JJ, Carroll AJ, Borowitz MJ, Pullen DJ, Camitta BM, Zutter MM, Watson
Leukemia 2000; 14: 238-40.
 
Cytogenetic findings in a population-based series of 787 childhood acute lymphatic leukemia.
Forestier E, Johansson B, Borgstr–m G, Kernddrup G, Johannsson J, Heim S.
Leukemia 2000; 64: 194-200.
 

Contributor(s)
Written06-2001Gitte Birk Kerndrup, Steen Rosthøj
Citation
This paper should be referenced as such :
Kerndrup GB, Rosthøj S . A case of pre-B ALL with t(8;14)(q11;q32). Atlas Genet Cytogenet Oncol Haematol. June 2001 .
URL : http://AtlasGeneticsOncology.org/Reports/t814KerndrupID100001.html

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