| Clinics and Pathology |
| Etiology | Intravenous leiomyomatosis (IVL) is a rare smooth muscle proliferation of special interest because of its quasi-malignant behavior. |
| Clinics | IVL is a smooth muscle proliferation that arises from the uterus with vermiform extensions in some cases into the inferior vena cava and ultimately into the right heart. |
| Pathology | The neoplastic smooth muscle of intravenous leiomyomatosis resembles that of benign uterine leiomyomata and may include the same histological variants found in the uterus. Furthermore, the neoplastic smooth cells of IVL express estrogen and progesterone receptors and tumor growth appears to respond to hormonal manipulation. |
| Treatment | Although benign, its hemodynamic effects may require invasive extirpation. |
| Cytogenetics |
| Cytogenetics Morphological | There are only two cytogenetic reports in IVL and both exhibited a karyotype with a der(14)t(12;14)(q15;q24) and two normal copies of chromosome 12. Fluorescence in situ hybridization revealed three copies of HMGA2 (a.k.a. HMGIC): two signals were detected on the normal chromosomes 12 at 12q15, as well as another on the der(14) in the breakpoint region, suggesting that the 12q breakpoint occurred 5' (centromeric) to HMGA2, as has been commonly observed and previously described in uterine leiomyoma with a t(12;14). Based on these findings, it has been suggested that the pathogenesis of IVL is more similar to that of typical uterine leiomyoma than it is to leiomyosarcoma. |
| Bibliography |
| Intravenous leiomyomatosis of the uterus. A clinicopathological analysis of 16 cases with unusual histologic features. |
| Clement PB, Young RH, Scully RE. |
| Am J Surg Pathol 1988; 12: 932-945. |
| PMID 3202247 |
| Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case. |
| Quade B J, Dal Cin P, Neskey D M, Weremowicz S, Morton C C. |
| Mod Pathol 2002; 15: 351-356. |
| PMID 11904348 |
| Intravenous leiomyomatosis is characterized by a der(14) t(12;14) (q15;q24). |
| Dal Cin P, Quade BJ, Neskey DM, Kleinman MS, Weremowicz S, Morton CC. |
| Genes Chromosomes Cancer 2003; 36(2): 205-206. |
| PMID 12508249 |
| Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15. |
| Quade BJ, Weremowicz S, Neskey DM, Vanni R, Ladd C, Dal Cin P, Morton CC. |
| Cancer Res 2003; 63(6):1351-1358. |
| PMID 12649198 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 07-2003 | Paola Dal Cin |
| Cytogenetics Laboratory, Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Amory 3-154, Boston, Massachusetts 02115, USA |
| Citation |
| This paper should be referenced as such : |
| Dal Cin P . Smooth muscle: Intravenous leiomyomatosis. Atlas Genet Cytogenet Oncol Haematol. July 2003 . URL : http://AtlasGeneticsOncology.org/Tumors/IntravLeiomyomID5158.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Thu Apr 17 14:14:35 2008 |
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