15q13-15 Rearrangements

Clinics and Pathology

Disease	Acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CML), chronic lymphocytic leukemia (CLL) and non Hodgkin lymphomas (NHL).
Phenotype / cell stem origin	Most ALL are B-lineage, few T-lineage. AML: most subtypes. CML: Lymphomas: described in follicular, diffuse large B-cell, mantle cell and anaplastic large cell, as well as Hodgkin lymphomas.
Epidemiology	Rare in childhood ALL (about 1%), more common in infant ALL (about 13%). Very rare in AML, adult ALL, CLL and lymphomas. Occurs in primary and secondary leukemias. CML: rare, occurs as secondary abnormality or part of complex Ph rearrangement
Prognosis	Childhood ALL: No increased risk with current treatment regimens. Outcome not described in other diseases.

Cytogenetics

Additional anomalies

Various anomalies result in 15q13-15 breakpoints, most frequently balanced translocations, but also unbalanced translocations and deletions. Childhood ALL: 15q13-15 breakpoints frequently occur in complex karyotypes. Associated abnormalities of 9p and of 12p 12p, as well as t(9;22)(q34;q11.2) are common. 15q13-15 breakpoints also have been reported with der(19)t(1;19)(q21;q13). A t(5;15)(p15.1 or p15.3;q11 or q13) occurs primarily in infant ALL, although also was reported in one adolescent ALL. AML: found as primary abnormality and as secondary abnormality, with various other abnormalities including t(9;22)(q34;q11.2), t(8;21)(q22;q22), as well as part of complex rearrangements with 8q22 and 21q22. Recurrent aberrations are: t(11;15)(q23;q14) reported in both AML and ALL and t(12;15)(p12-13;q13-15) in AML. CML: occurs in variant Ph and in secondary abnormalities.

Bibliography

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Abnormalities of chromosome bands 15q13-15 in childhood acute lymphoblastic leukemia.

Heerema NA, Sather HN, Sensel MG, La MK, Hutchinson RJ, Nachman JB, Reaman GH, Lange BJ, Steinherz PG, Bostrom BC, Gaynon PS, Uckun FM

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PMID 11920481

Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: impact of the 11q23 breakpoint on outcome: a report of the Childrens Cancer Group.

Heerema NA, Arthur DC, Sather H, Albo V, Feusner J, Lange BJ, Steinherz PG, Zeltzer P, Hammond D, Reaman GH

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Contributor(s)

Written	09-2003	Nyla A Heerema

Citation

This paper should be referenced as such :

Heerema NA . 15q13-15 Rearrangements. Atlas Genet Cytogenet Oncol Haematol. Septem ber 2003 . URL : http://AtlasGeneticsOncology.org/Genes/15q13rearID1257.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:18:49 2008

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